Recent Advances in the Clinical Translation of Small-Cell Lung Cancer Therapeutics

Subhadeep Das,S. Samaddar

Published 2025 in Cancers

ABSTRACT

Simple Summary Small-cell lung cancer (SCLC) is an aggressive type of lung cancer, often linked to a poor prognosis for the majority of patients. Platinum–etoposide-based chemotherapy, combined with immunotherapy, constitutes the standard treatment for patients with small-cell lung cancer (SCLC). Nonetheless, SCLC often recurs and develops resistance to treatment. The development of targeted treatment options for patients with SCLC has presented challenges; however, several emerging therapies demonstrate potential efficacy. Recent progress in SCLC research has uncovered essential insights into the biological traits of the disease, which could facilitate the discovery of biomarkers. Additionally, evaluating novel therapies will be crucial for enhancing treatment outcomes for patients with SCLC.

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