BLM helicase facilitates telomere replication during leading strand synthesis of telomeres

BLM helicase facilitates telomere replication by resolving G-quadruplex structures that can form in the G-rich repeats during leading strand synthesis.

• Publication year

  2015

• Venue

  Journal of Cell Biology

• Publication date

  2015-07-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201410061PMID 26195664PMCID 4508891
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3).

  2014cited by this paper
• Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

  2014cited by this paper
• Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

  2014cited by this paper
• Human RecQ helicases in DNA repair, recombination, and replication.

  2014cited by this paper
• The G4 Genome

  2013cited by this paper
• Detection of G-quadruplex DNA in mammalian cells

  2013cited by this paper
• Quantitative visualization of DNA G-quadruplex structures in human cells.

  2013cited by this paper
• Inhibition of DNA synthesis facilitates expansion of low‐complexity repeats

  2013cited by this paper
• Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation.

  2013cited by this paper
• The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

  2012cited by this paper
• RecQ helicases in DNA double strand break repair and telomere maintenance.

  2012cited by this paper
• Human telomeres replicate using chromosome-specific, rather than universal, replication programs

  2012influential reference
• FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

  2011cited by this paper
• Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

  2011cited by this paper
• The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.

  2011cited by this paper
• G‐quadruplex‐induced instability during leading‐strand replication

  2011influential reference
• Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

  2011cited by this paper
• Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae

  2010cited by this paper
• Purification of proteins associated with specific genomic Loci.

  2009cited by this paper
• Decreased replication origin activity in temporal transition regions

  2009cited by this paper
• Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

  2009cited by this paper
• Telomeres do the (un)twist: helicase actions at chromosome termini.

  2009cited by this paper
• Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.

  2009cited by this paper
• FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts*

  2008cited by this paper
• FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

  2008cited by this paper
• Ligands playing musical chairs with G-quadruplex DNA: a rapid and simple displacement assay for identifying selective G-quadruplex binders.

  2008cited by this paper
• Replication fork movement sets chromatin loop size and origin choice in mammalian cells

  2008cited by this paper
• Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.

  2008cited by this paper
• Highly efficient G-quadruplex recognition by bisquinolinium compounds.

  2007cited by this paper
• Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells.

  2007cited by this paper
• Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action

  2007cited by this paper
• Endogenous γ-H2AX-ATM-Chk2 Checkpoint Activation in Bloom's Syndrome Helicase–Deficient Cells Is Related to DNA Replication Arrested Forks

  2007cited by this paper
• How telomeres are replicated

  2007cited by this paper
• Application of phage display to high throughput antibody generation and characterization

  2007cited by this paper
• BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges

  2007cited by this paper
• The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.

  2006cited by this paper
• Quadruplex DNA: sequence, topology and structure

  2006cited by this paper
• QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences

  2006cited by this paper
• A simple vector system to improve performance and utilisation of recombinant antibodies

  2006influential reference
• Murine Pif1 Interacts with Telomerase and Is Dispensable for Telomere Function In Vivo

  2006cited by this paper
• Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.

  2006cited by this paper
• The Bloom's Syndrome Helicase Can Promote the Regression of a Model Replication Fork*

  2006cited by this paper
• Shelterin: the protein complex that shapes and safeguards human telomeres.

  2005cited by this paper
• Prevalence of quadruplexes in the human genome

  2005cited by this paper
• POT1 Stimulates RecQ Helicases WRN and BLM to Unwind Telomeric DNA Substrates*

  2005cited by this paper
• Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

  2005cited by this paper
• Progressive activation of DNA replication initiation in large domains of the immunoglobulin heavy chain locus during B cell development.

  2005cited by this paper
• Plasticity of DNA Replication Initiation in Epstein-Barr Virus Episomes

  2004cited by this paper
• Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

  2004influential reference
• Telomere Shortening Exposes Functions for the Mouse Werner and Bloom Syndrome Genes

  2004cited by this paper
• Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2.

  2004cited by this paper
• Chromosome instability and tumor predisposition inversely correlate with BLM protein levels.

  2003influential reference
• Telomere-binding Protein TRF2 Binds to and Stimulates the Werner and Bloom Syndrome Helicases*

  2002cited by this paper
• Visualization of DNA Replication on Individual Epstein-Barr Virus Episomes

  2001influential reference
• The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

  2001cited by this paper
• Cancer predisposition caused by elevated mitotic recombination in Bloom mice

  2000influential reference
• Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background

  2000cited by this paper
• Mammalian telomeres end in a large duplex loop.

  1999cited by this paper
• Human Werner Syndrome DNA Helicase Unwinds Tetrahelical Structures of the Fragile X Syndrome Repeat Sequence d(CGG) n *

  1999cited by this paper
• A general protocol for evaluating the specific effects of DNA replication inhibitors.

  1993cited by this paper
• A retarded rate of DNA chain growth in Bloom's syndrome.

  1975cited by this paper

• BLM and FANCJ role in the response to G-quadruplex-dependent telomeric replicative stress

  2026cites this paper
• The Werner syndrome RECQ helicase as a therapeutic target: new insights

  2026cites this paper
• Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase

  2025cites this paper
• Rescue from pyridostatin-stabilized telomeric G-quadruplexes by DNA cleavage and microhomology-mediated end joining

  2025cites this paper
• DNA replication: causes of replication stress and DNA damage response pathways

  2025influential citation
• Molecular Tools for Precision Targeting and Detection of G-Quadruplex Structures

  2025cites this paper
• Long-term effects of BCG vaccination on telomere length and telomerase activity

  2025cites this paper
• Conserved and unique features of terminal telomeric sequences in ALT-positive cancer cells

  2025cites this paper
• Cellular adaptations impact the biological activity of naphthalene diimide G-quadruplex ligands in ALT-positive osteosarcoma cells

  2025cites this paper
• Host helicase DHX36 inhibits pseudorabies virus proliferation by unwinding the G-quadruplex in the 3'UTR of IE180.

  2025cites this paper
• In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function.

  2025cites this paper
• Characterization of the Helicase activity of Pif-like Helicases from Arabidopsis thaliana and role in gene regulation and abiotic stress response.

  2025cites this paper
• Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer Cells

  2025cites this paper
• RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining

  2025cites this paper
• Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics

  2025cites this paper
• Knot-knot chronicles: unveiling the G-quadruplexes

  2025cites this paper
• Telomere Length and Cancer

  2025cites this paper
• How DNA secondary structures drive replication fork instability

  2025cites this paper
• Clinical application and immune infiltration landscape of stemness‐related genes in heart failure

  2024cites this paper
• Genomic, phenomic, and geographic associations of leukocyte telomere length in the United States

  2024cites this paper
• Telomere maintenance and the DNA damage response: a paradoxical alliance

  2024influential citation
• G-quadruplex DNA and RNA in cellular senescence

  2024cites this paper
• TRF2–RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM–DNA2-dependent 5′-end resection

  2024cites this paper
• G-quadruplexes are a source of vulnerability in BRCA2 deficient granule cell progenitors and medulloblastoma

  2024cites this paper
• Werner helicase interacting protein 1 contributes to G-quadruplex processing in human cells

  2024cites this paper
• Balancing act: BRCA2's elaborate management of telomere replication through control of G-quadruplex dynamicity.

  2024cites this paper
• Replication stress as a driver of cellular senescence and aging

  2024cites this paper
• Understanding, diagnosing, and treating pancreatic cancer from the perspective of telomeres and telomerase

  2024cites this paper
• BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response.

  2024cites this paper
• The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges

  2024cites this paper
• Spotlight on G-Quadruplexes: From Structure and Modulation to Physiological and Pathological Roles

  2024cites this paper
• Guardians of the Genome: How the Single-Stranded DNA-Binding Proteins RPA and CST Facilitate Telomere Replication

  2024cites this paper
• Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells

  2024cites this paper
• RPA engages telomeric G-quadruplexes more effectively than CST

  2023cites this paper
• Joint Efforts of Replicative Helicase and SSB Ensure Inherent Replicative Tolerance of G‐Quadruplex

  2023cites this paper
• The function of Bazhen decoction in rescuing progeroid cell senescence via facilitating G-quadruplex resolving and telomere elongation.

  2023cites this paper
• BG4 antibody can recognize telomeric G-quadruplexes harboring destabilizing base modifications and lesions

  2023cites this paper
• R-Loops in Genome Instability and Cancer

  2023cites this paper
• Modified iPOND revealed the role of mutant p53 in promoting helicase function and telomere maintenance

  2023cites this paper
• G-quadruplexes of KSHV oriLyt play important roles in promoting lytic DNA replication

  2023cites this paper
• A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G-quadruplex resolution

  2023cites this paper
• Non-canonical DNA structures in the human ribosomal DNA

  2023influential citation
• G-quadruplex resolution: From molecular mechanisms to physiological relevance.

  2023cites this paper
• Cooperative interaction of CST and RECQ4 resolves G‐quadruplexes and maintains telomere stability

  2023cites this paper
• Understanding G-Quadruplex Biology and Stability Using Single-Molecule Techniques.

  2023cites this paper
• G-quadruplexes and associated proteins in aging and Alzheimer’s disease

  2023influential citation
• Stn1-Ten1 and Taz1 independently promote replication of subtelomeric fragile sequences in fission yeast.

  2023cites this paper
• Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter

  2022cites this paper
• Functions of ADP-ribose transferases in the maintenance of telomere integrity

  2022cites this paper
• RecQ1 helicase unwinds G-Quadruplexes at oriLyt to facilitate KSHV Lytic DNA Replication

  2022cites this paper
• The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance

  2022cites this paper
• TERRA regulates DNA G-quadruplex formation and ATRX recruitment to chromatin

  2022cites this paper
• TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R- to D-loop switch.

  2022cites this paper
• Creation and resolution of non-B-DNA structural impediments during replication

  2022cites this paper
• Ligands stimulating antitumour immunity as the next G-quadruplex challenge

  2022cites this paper
• Telomere Length Regulation

  2022cites this paper
• BLM Sumoylation Is Required for Replication Stability and Normal Fork Velocity During DNA Replication

  2022cites this paper
• WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer

  2022cites this paper
• Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids

  2022cites this paper
• Bloom syndrome and the underlying causes of genetic instability.

  2021cites this paper
• TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress

  2021cites this paper
• Human RecQ Helicases in DNA Double-Strand Break Repair

  2021cites this paper
• Functions of BLM Helicase in Cells: Is It Acting Like a Double-Edged Sword?

  2021cites this paper
• Blm Helicase Facilitates Rapid Replication of Repetitive DNA Sequences in early Drosophila Development

  2021cites this paper
• A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes

  2021cites this paper
• G-Quadruplex Assembly by Ribosomal DNA: Emerging Roles in Disease Pathogenesis and Cancer Biology

  2021influential citation
• Preventing excess replication origin activation to ensure genome stability.

  2021cites this paper
• Guanine Quadruplexes in Cell Nucleus Metabolism

  2021cites this paper
• G-quadruplex DNA: a novel target for drug design

  2021cites this paper
• Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma

  2021cites this paper
• Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites

  2021cites this paper
• The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans

  2021influential citation
• TARGETING TELOMERASE FOR CANCER THERAPY

  2020cites this paper
• The human telomeric proteome during telomere replication

  2020cites this paper
• DNA helicases and their roles in cancer.

  2020cites this paper
• Fundamentals of G-quadruplex biology

  2020cites this paper
• G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders

  2020cites this paper
• The genetic script of metastasis

  2020cites this paper
• Helicase

  2020cites this paper
• Telomere replication-When the going gets tough.

  2020cites this paper
• Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres

  2020cites this paper
• G-Quadruplexes at Telomeres: Friend or Foe?

  2020cites this paper
• G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders

  2020cites this paper
• TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere Dysfunction

  2020cites this paper
• DNA folds threaten genetic stability and can be leveraged for chemotherapy

  2020cites this paper
• Resolving Roadblocks to Telomere Replication.

  2019cites this paper
• Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction

  2019cites this paper
• G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets.

  2019cites this paper
• G‐quadruplexes in fibrotic scars may open new therapeutic avenues for wound healing

  2019cites this paper
• Regulation of Replication and Translation During KSHV Life Cycle

  2019cites this paper
• Helicases FANCJ, RTEL1 and BLM Act on Guanine Quadruplex DNA in Vivo

  2019influential citation
• Mechanisms of DNA Replication and Repair: Insights from the Study of G-Quadruplexes

  2019cites this paper
• Novel Insights into the Multifaceted Roles of BLM in the Maintenance of Genome Stability

  2019cites this paper
• The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

  2019cites this paper
• Stem cells, immortality, and the evolution of metastatic properties in breast cancer: telomere maintenance mechanisms and metastatic evolution.

  2019cites this paper
• Direct Visualization of DNA Replication at Telomeres Using DNA Fiber Combing Combined with Telomere FISH.

  2019cites this paper
• BLM’s balancing act and the involvement of FANCJ in DNA repair

  2018cites this paper
• Emerging roles of CST in maintaining genome stability and human disease.

  2018cites this paper
• hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability

  2018cites this paper
• Chromosome instability syndromes

  2018cites this paper