Phage treatment of multidrug-resistant bacterial infections in humans, animals, and plants: The current status and future prospects

Omor Faruk,Z. Jewel,Sanjoy Bairagi,Mohammad Rasheduzzaman,Hindol Bagchi,Akber Subahan Mahbub Tuha,Imran Hossain,Ayon Bala,Sarafat Ali

Published 2025 in Infectious Medicine

ABSTRACT

Highlights • Phage therapy targets multidrug-resistant bacterial infections.• Offers advantages like biofilm disruption and microbiota preservation.• Provides benefits compared to antibiotics by preserving the host's microbiota.• Potential to serve as a replacement or complement for antibiotics.• Faces challenges like narrow host range and regulatory hurdles.• Future optimizations include phage cocktails and genetic modifications.

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