Deep eutectic solvents in food contaminants detection: Characteristics, interaction mechanism and application advances from extracting to other roles.

Peiyi Wang,Changhong Liu

Published 2025 in Food Chemistry

ABSTRACT

Food safety is crucial for public health, yet it faces growing threats from environmental and anthropogenic pollutants. Deep eutectic solvents (DESs) have emerged as green and efficient alternative solvents for detecting trace pollutants. This review highlights the characteristics of DESs, their mechanisms for extracting target analytes and applications in food analysis. Subsequently, the challenges faced by DESs in the detection of food samples and future development trends are further discussed. DESs can selectively interact with various target analytes (including pesticides, veterinary drugs, food additives, heavy metals, toxins, and other residues) during the food safety testing process by forming hydrogen bond networks. Beyond serving as extraction solvents, DESs can act as adsorbents, eluents, and reaction media, thereby simplifying sample pretreatment and enhancing the detection performance of various contaminants. Overall, as customizable functional solvents, DESs hold great promise for advancing next-generation food analysis methods, though some technical barriers remain to be addressed.

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