Loss of ING3 in the Prostate Leads to Activation of DNA Damage Repair Markers

Simple Summary Prostate cancer is the most common cancer found in men, necessitating the study of genes implicated in the initiation and progression of this disease. The inhibitor of growth family member 3 (ING3) is an epigenetic regulator, whose role in prostate cancer is unknown. The aim of our study was to investigate the functional consequences of prostate-specific ablation of ING3 in mice. While we found normal prostate tissue histoarchitecture in the prostate-specific Ing3 knockout mice, increased expression of DNA-damage-associated markers suggests a role for ING3 in maintaining genomic stability. Altogether, our data show that loss of Ing3 does not lead to neoplastic transformation of the prostate.

• Publication year

  2025

• Venue

  Cancers

• Publication date

  2025-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/cancers17061037PMID 40149370PMCID 11940784
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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