Tethering by lamin A stabilizes and targets the ING1 tumour suppressor

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Nature Cell Biology

• Publication date

  2008-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncb1792PMID 18836436
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression profiles of mRNA transcript variants encoding the human inhibitor of growth tumor suppressor gene family in normal and neoplastic tissues.

  2008cited by this paper
• Perturbation of wild‐type lamin A metabolism results in a progeroid phenotype

  2008cited by this paper
• After a decade of study-ING, a PHD for a versatile family of proteins.

  2007cited by this paper
• MascotDatfile: An open‐source library to fully parse and analyse MASCOT MS/MS search results

  2007cited by this paper
• Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.

  2007cited by this paper
• Nuclear lamins: laminopathies and their role in premature ageing.

  2006cited by this paper
• The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation.

  2006cited by this paper
• ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

  2006cited by this paper
• Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4

  2006influential reference
• Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging.

  2006cited by this paper
• ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

  2006influential reference
• Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2

  2006cited by this paper
• Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.

  2006cited by this paper
• The laminopathies: the functional architecture of the nucleus and its contribution to disease.

  2006cited by this paper
• The Yng1p Plant Homeodomain Finger Is a Methyl-Histone Binding Module That Recognizes Lysine 4-Methylated Histone H3

  2006influential reference
• ING2 Regulates the Onset of Replicative Senescence by Induction of p300-Dependent p53 Acetylation

  2005cited by this paper
• Phylogenetic analysis of the ING family of PHD finger proteins.

  2005cited by this paper
• Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome

  2004cited by this paper
• A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.

  2004cited by this paper
• Proteins that bind A-type lamins: integrating isolated clues

  2004cited by this paper
• Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

  2003cited by this paper
• Downregulation of nuclear expression of the p33ING1b inhibitor of growth protein in invasive carcinoma of the breast

  2003cited by this paper
• Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.

  2003influential reference
• Human ING1 Proteins Differentially Regulate Histone Acetylation*

  2002cited by this paper
• ING1 isoforms differentially affect apoptosis in a cell age-dependent manner.

  2002cited by this paper
• Role of the Sin3-Histone Deacetylase Complex in Growth Regulation by the Candidate Tumor Suppressor p33ING1

  2002cited by this paper
• RBP1 Recruits the mSIN3-Histone Deacetylase Complex to the Pocket of Retinoblastoma Tumor Suppressor Family Proteins Found in Limited Discrete Regions of the Nucleus at Growth Arrest

  2001cited by this paper
• UV-induced binding of ING1 to PCNA regulates the induction of apoptosis.

  2001cited by this paper
• Nuclear Lamins a and B1

  2000cited by this paper
• Three Yeast Proteins Related to the Human Candidate Tumor Suppressor p33ING1 Are Associated with Histone Acetyltransferase Activities

  2000cited by this paper
• Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy

  1999cited by this paper
• Dynamics of the nuclear lamina as monitored by GFP-tagged A-type lamins.

  1999cited by this paper
• Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor

  1997cited by this paper
• A chromatin binding site in the tail domain of nuclear lamins that interacts with core histones

  1995cited by this paper
• Complex formation between lamin A and the retinoblastoma gene product: identification of the domain on lamin A required for its interaction.

  1994cited by this paper

• A recently evolved domain of the human ING1 epigenetic regulator targets mitochondria and induces senescence

  2026cites this paper
• Loss of ING3 in the Prostate Leads to Activation of DNA Damage Repair Markers

  2025cites this paper
• ING5: multifaceted roles beyond tumor suppression in cellular physiology and disease

  2025cites this paper
• Inhibitor of Growth Proteins: Epigenetic Regulators Shaping Neurobiology

  2025cites this paper
• The structure and function of lamin A/C: Special focus on cardiomyopathy and therapeutic interventions.

  2024cites this paper
• The Nuclear Envelope as a Regulator of Immune Cell Function

  2022cites this paper
• Case report: Focal segmental glomerulosclerosis in a pediatric atypical progeroid syndrome

  2022cites this paper
• Epigenetic regulation of the cell cycle & DNA-repair in cancer

  2021cites this paper
• Roles of the tumor suppressor inhibitor of growth family member 4 (ING4) in cancer.

  2021cites this paper
• Hutchinson-Gilford progeria syndrome

  2020cites this paper
• Emerging roles of lamins and DNA damage repair mechanisms in ovarian cancer.

  2020cites this paper
• Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.

  2019cites this paper
• Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing.

  2019cites this paper
• Biological Functions of the ING Proteins

  2019cites this paper
• The ING1a model of rapid cell senescence.

  2019cites this paper
• Are There Common Mechanisms Between the Hutchinson–Gilford Progeria Syndrome and Natural Aging?

  2019cites this paper
• The essential role of tumor suppressor gene ING4 in various human cancers and non-neoplastic disorders

  2019cites this paper
• Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

  2019cites this paper
• The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks

  2018cites this paper
• Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging

  2018cites this paper
• E3 ubiquitin ligase HECW2 targets PCNA and lamin B1.

  2018cites this paper
• Genomic instability and DNA replication defects in progeroid syndromes

  2018cites this paper
• E3 ubiquitin ligase RNF123 targets lamin B1 and lamin‐binding proteins

  2018cites this paper
• INGs are potential drug targets for cancer

  2017cites this paper
• DisorderING promotes epigenetic order

  2017cites this paper
• Role of Liprins in the Regulation of Tumor Cell Motility and Invasion.

  2016cites this paper
• Recent advances in understanding the role of lamins in health and disease

  2016cites this paper
• Do lamin A and lamin C have unique roles?

  2015cites this paper
• A minimal ING1b fragment that improves the efficacy of HDAC-based cancer cell killing

  2015cites this paper
• Epigenetic Changes in Aging and Age-related Disease

  2015cites this paper
• LincRNA-p21 acts as a mediator of ING1b-induced apoptosis

  2015cites this paper
• Defining the minimal peptide sequence of the ING1b tumour suppressor capable of efficiently inducing apoptosis

  2015cites this paper
• The Emerging Role of Inhibitor of Growth 4 as a Tumor Suppressor in Multiple Human Cancers

  2015cites this paper
• SUMOylation of the ING1b tumor suppressor regulates gene transcription.

  2014cites this paper
• Function of the ING Proteins in Cancer and Senescence

  2014cites this paper
• Keep‐ING balance: Tumor suppression by epigenetic regulation

  2014cites this paper
• A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression

  2014cites this paper
• The ING tumor suppressor genes: status in human tumors.

  2014cites this paper
• Expression Epigenetic Factors That Regulate Herpesviral Gene A Targeted RNA Interference Screen Reveals Novel 2014

  2014cites this paper
• Tumor Dormancy, Quiescence, and Senescence, Volume 2

  2014cites this paper
• Epigenetic Involvement in Hutchinson-Gilford Progeria Syndrome: A Mini-Review

  2014cites this paper
• The ING1a Tumor Suppressor Regulates Endocytosis to Induce Cellular Senescence Via the Rb-E2F Pathway

  2013cites this paper
• Partners and post-translational modifications of nuclear lamins

  2013cites this paper
• RegulatING chromatin regulators: post-translational modification of the ING family of epigenetic regulators.

  2013cites this paper
• Hutchinson–Gilford progeria syndrome through the lens of transcription

  2013influential citation
• Src Regulates the Activity of the ING1 Tumor Suppressor

  2013cites this paper
• Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

  2013cites this paper
• ING1 and ING2: multifaceted tumor suppressor genes

  2013cites this paper
• Cytoplasmic expression of p33(ING1b) is correlated with tumorigenesis and progression of human esophageal squamous cell carcinoma.

  2013cites this paper
• with tumorigenesis and progression of human esophageal squamous cell carcinoma

  2013cites this paper
• The nuclear envelope environment and its cancer connections

  2012cites this paper
• The nuclear lamins: flexibility in function

  2012cites this paper
• GLAD4U: deriving and prioritizing gene lists from PubMed literature

  2012cites this paper
• The role of intranuclear lamin complexes in muscular dystrophy

  2012cites this paper
• Novel Roles for A-Type Lamins in Maintaining Genomic Stability

  2012cites this paper
• Cytoplasmic expression of p 33 ( ING 1 b ) is correlated with tumorigenesis and progression of human esophageal squamous cell carcinoma

  2012cites this paper
• ING1 and 5-Azacytidine Act Synergistically to Block Breast Cancer Cell Growth

  2012cites this paper
• Lamin A, farnesylation and aging.

  2012cites this paper
• Characterizing the interaction between Inhibitor of Growth (ING) proteins and the nucleosome

  2012cites this paper
• A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction

  2012cites this paper
• Prevention and Early Detection of Head and Neck Squamous Cell Cancers

  2012cites this paper
• Adenovirus-mediated expression of p33ING1b induces apoptosis and inhibits proliferation in gastric adenocarcinoma cells in vitro

  2012cites this paper
• Domain Recognition of the ING1 Tumor Suppressor by a Panel of Monoclonal Antibodies

  2011cites this paper
• mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

  2011cites this paper
• Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: Evidence for synergy with Topoisomerase-I inhibition

  2011cites this paper
• Recapitulation of premature aging with iPSCs from Hutchinson-Gilford progeria syndrome

  2011cites this paper
• Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis.

  2011cites this paper
• A dual role for A-type lamins in DNA double-strand break repair

  2011cites this paper
• The Defective Nuclear Lamina in Hutchinson-Gilford Progeria Syndrome Disrupts the Nucleocytoplasmic Ran Gradient and Inhibits Nuclear Localization of Ubc9

  2011cites this paper
• Role of ING Family Tumor Suppressors in Breast Cancer

  2011cites this paper
• The p53 Tumor Suppressor Is Stabilized by Inhibitor of Growth 1 (ING1) by Blocking Polyubiquitination

  2011cites this paper
• The multiple roles of A-type lamins in cellular aging, cell cycle progression and the DNA damage response.

  2011cites this paper
• Nurturing the genome

  2010cites this paper
• Nuclear lamins.

  2010cites this paper
• A-type lamins preserve genomic stability

  2010cites this paper
• Lamina-independent lamins in the nuclear interior serve important functions.

  2010cites this paper
• The nuclear envelope at a glance

  2010cites this paper
• The ING family tumor suppressors: from structure to function

  2010cites this paper
• Nurturing the genome: A-type lamins preserve genomic stability.

  2010cites this paper
• Lamins: 'structure goes cycling'.

  2010cites this paper
• ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma

  2010cites this paper
• A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis.

  2010cites this paper
• Progeria syndromes and ageing: what is the connection?

  2010cites this paper
• Natural and artificial routes to pluripotency.

  2010cites this paper
• The role of lamin A and emerin in mediating genome organisation

  2010cites this paper
• Lamin-binding Proteins.

  2010cites this paper
• The return of the INGs, histone mark sensors and phospholipid signaling effectors.

  2009cites this paper
• Altered Nuclear Functions in Progeroid Syndromes: a Paradigm for Aging Research

  2009cites this paper
• The Caenorhabditis elegans ing-3 Gene Regulates Ionizing Radiation-Induced Germ-Cell Apoptosis in a p53-Associated Pathway

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• Reviewing the current classification of inhibitor of growth family proteins

  2009cites this paper
• Identification of arsenic-binding proteins in human cells by affinity chromatography and mass spectrometry.

  2009cites this paper
• Intermediate filaments: primary determinants of cell architecture and plasticity.

  2009cites this paper
• ING proteins as potential anticancer drug targets.

  2009cites this paper
• Telomere length in Hutchinson-Gilford progeria syndrome.

  2009influential citation
• Potential usage of ING family members in cancer diagnostics and molecular therapy.

  2009cites this paper
• The role of ING tumor suppressors in UV stress response and melanoma progression.

  2009cites this paper
• Structural insight into histone recognition by the ING PHD fingers.

  2009cites this paper
• Novel roles for A‐type lamins in telomere biology and the DNA damage response pathway

  2009influential citation
• Signaling pathways of the ING proteins in apoptosis.

  2009cites this paper
• Emerging Role of C/EBP b and Epigenetic DNA Methylation in Ageing

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