New Coumarin Derivatives as Potent Selective COX‐2 Inhibitors: Synthesis, Anti‐Inflammatory, QSAR, and Molecular Modeling Studies

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Archiv der Pharmazie

• Publication date

  2015-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/ardp.201500274PMID 26462142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ultrasound promoted one pot synthesis of novel fluorescent triazolyl spirocyclic oxindoles using DBU based task specific ionic liquids and their antimicrobial activity.

  2014cited by this paper
• Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.

  2014cited by this paper
• Synthesis, in vitro antiproliferative activity, and in silico studies of fused tricyclic coumarin sulfonate derivatives.

  2014cited by this paper
• Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties.

  2014cited by this paper
• Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.

  2012cited by this paper
• Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors.

  2012cited by this paper
• Duration of Treatment With Nonsteroidal Anti-Inflammatory Drugs and Impact on Risk of Death and Recurrent Myocardial Infarction in Patients With Prior Myocardial Infarction: A Nationwide Cohort Study

  2011cited by this paper
• The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life.

  2010cited by this paper
• The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: the three microdose candidates.

  2010cited by this paper
• Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1H-pyrazole as anti-inflammatory antimicrobial agents.

  2008cited by this paper
• Cyclooxygenase-2 inhibitors: a painful lesson.

  2006cited by this paper
• Antiinflammatory and antioxidant evaluation of novel coumarin derivatives

  2006cited by this paper
• Synthesis and antiinflammatory activity of coumarin derivatives.

  2005cited by this paper
• Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

  2004cited by this paper
• Natural and synthetic coumarin derivatives with anti-inflammatory/ antioxidant activities.

  2004cited by this paper
• Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.

  2004cited by this paper
• COX-2 inhibitors vs. NSAIDs in gastrointestinal damage and prevention

  2001cited by this paper
• Cyclooxygenase enzymes: catalysis and inhibition.

  2001cited by this paper
• Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors.

  2001cited by this paper
• Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors.

  2000cited by this paper
• Cyclooxygenase-2 inhibition and side-effects of non-steroidal anti-inflammatory drugs in the gastrointestinal tract.

  2000cited by this paper
• Specific cyclooxygenase 2 inhibitors: a new choice of nonsteroidal anti-inflammatory drug therapy.

  1999cited by this paper
• Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors.

  1999cited by this paper
• COX-1 and COX-2 in health and disease

  1999cited by this paper
• Profile and mechanisms of gastrointestinal and other side effects of nonsteroidal anti-inflammatory drugs (NSAIDs).

  1999cited by this paper
• Profile of JTE-522 as a human cyclooxygenase-2 inhibitor.

  1998cited by this paper
• A fast flexible docking method using an incremental construction algorithm.

  1996cited by this paper
• Renal toxicity of the nonsteroidal anti-inflammatory drugs.

  1993cited by this paper
• Partial least-squares regression: a tutorial

  1986cited by this paper
• Effect of long term estrogen and lithium treatment on restraint induced gastric erosion in intact and ovariectomized rats.

  1982cited by this paper
• Screens for anti‐inflammatory drugs

  1971cited by this paper

• Design, synthesis and computational studies of new azaheterocyclic coumarin derivatives as anti-Mycobacterium tuberculosis agents targeting enoyl acyl carrier protein reductase (InhA)

  2024cites this paper
• Synthesis, characterization, and anticancer potency of coumarin-derived thiosemicarbazones and their Copper(II) complexes

  2024cites this paper
• Design, synthesis, anti-trypsin and anti-inflammatory evaluation of new guanidinobenzoic acid ester derivatives

  2024cites this paper
• Exploring the bioactive potential of (2-imino-4-oxo-1,3-thiazolidin-5-yl)acetic acid derivatives: A comprehensive review

  2024cites this paper
• Synthesis, characterization, anticancer activity, molecular docking and DFT calculation of 3-acetylcoumarin thiosemicarbazones and Schiff’s bases

  2024cites this paper
• Design, Synthesis, and Docking of Novel Tropane Hybrids as Potent Hsp90 Inhibitors with Potential Anti-Breast Cancer Activity.

  2024cites this paper
• Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies

  2023cites this paper
• 2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms

  2023cites this paper
• Coumarins of Ferulopsis hystrix: LC–MS Profiling and Gastroprotective and Antioxidant Activities of Skimmin and Peucenidin

  2023cites this paper
• Investigating the Use of Coumarin Derivatives as Lasers

  2023cites this paper
• Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective

  2023cites this paper
• N-Tosylindole-coumarin with high fluorescence quantum yield and their potential applications

  2022cites this paper
• A new series of thiosemicarbazone‐based anti‐inflammatory agents exerting their action through cyclooxygenase inhibition

  2022cites this paper
• Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents

  2022cites this paper
• Hydrotrope assisted green synthesis of dicoumarols and in silico and in vitro antibacterial, antioxidant and xanthine oxidase inhibition studies

  2022cites this paper
• Synthesis and biological evaluation of coumarin-quinone hybrids as multifunctional bioactive agents

  2022cites this paper
• Natural-derived COX-2 inhibitors as Anticancer Drugs: A Review of Their Structure Diversity and Mechanism of Action.

  2022cites this paper
• Therapeutic perspective of thiosemicarbazones derivatives in inflammatory pathologies: A summary of in vitro/in vivo studies.

  2021cites this paper
• Microwave-Assisted Synthesis of (Piperidin-1-yl)quinolin-3-yl)methylene)hydrazinecarbothioamides as Potent Inhibitors of Cholinesterases: A Biochemical and In Silico Approach

  2021cites this paper
• Synthesis of Some New Acetanilide Derivatives as COX Inhibitors and Assessment of Analgesic/ Anti-Inflammatory Activities

  2021cites this paper
• Molecular docking study of coumarin-hydroxybenzohydrazide hybrid as an inhibitor of carbonic anhydrases IX and XII

  2021cites this paper
• New preparation protocols for coumarin-thiosemicarbazone hybrids: solid state characterization, and in silico/NMR studies of the Z/E isomerization equilibria in solution

  2021cites this paper
• Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity

  2021cites this paper
• Synthesis, Characterization and Anti-Inflammatory Study of New Heterocyclic Coumarin Derivatives

  2021cites this paper
• Contemporary advances of cyclic molecules proposed for inflammation.

  2021cites this paper
• New ursolic acid derivatives bearing 1,2,3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo

  2021cites this paper
• Medicinal applications of coumarins bearing azetidinone and thiazolidinone moieties.

  2021cites this paper
• Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies.

  2020cites this paper
• Selective cyclooxygenase-2 inhibitors: A review of recent chemical scaffolds with promising anti-inflammatory and COX-2 inhibitory activities

  2020cites this paper
• Nanoparticles Based on Novel Carbohydrate-Functionalized Polymers

  2020cites this paper
• An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

  2020cites this paper
• Identification of drug candidates for breast cancer therapy through scaffold repurposing: A brief review.

  2020cites this paper
• Design, synthesis and biological evaluation of new bis(thiosemicarbazone) derivatives as potential targeted anticancer agents for non-small cell lung cancer

  2020cites this paper
• Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.

  2019cites this paper
• Classification of Cyclooxygenase-2 Inhibitors Using Support Vector Machine and Random Forest Methods

  2019cites this paper
• Synthesis & Anticancer Evaluation of New Substituted 2-(3,4- Dimethoxyphenyl)benzazoles.

  2019cites this paper
• Novel Nano-sizedbis-indoline Derivatives as Antitumor Agents

  2018cites this paper
• Facile Synthesis of Pyrazolo[3,4-c]pyrazoles Bearing Coumarine Ring as Anticancer Agents

  2018cites this paper
• Synthesis, docking and ADME prediction of novel 1,2,3-triazole-tethered coumarin derivatives as potential neuroprotective agents

  2018cites this paper
• Efficient Synthesis of New Benzofuran-based Thiazoles and Investigation of their Cytotoxic Activity Against Human Breast Carcinoma Cell Lines: Efficient Synthesis of New Benzofuran-based Thiazoles and Investigation of their Cytotoxic Activity Against Human Breast Carcinoma Cell Lines

  2018cites this paper
• Diastereoselective One-Pot Synthesis of Coumarin-4-carboxamido-3-esters via a Four-Component Isocyanide-Based Reaction and Molecular Docking Study

  2018cites this paper
• Novel Group of Imidazole Derivatives as Atypical Selective Cyclooxygenase-2 Inhibitors: Design, Synthesis and Biological Evaluation

  2018cites this paper
• SAR and QSAR models of cyclooxygenase-1 (COX-1) inhibitors

  2018cites this paper
• A QSAR Study for Analgesic and Anti‐inflammatory Activities of 5‐/6‐Acyl‐3‐alkyl‐2‐Benzoxazolinone Derivatives

  2018cites this paper
• Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.

  2018cites this paper
• Synthesis, molecular docking studies and biological evaluation of potent coumarin-thiazolidinone hybrids: An approach to microwave synthesis

  2018cites this paper
• Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents

  2017cites this paper
• New Coumarin Derivatives as Anti‐Breast and Anti‐Cervical Cancer Agents Targeting VEGFR‐2 and p38α MAPK

  2017cites this paper
• Synthesis of Some New Azoloazines with Potent Anti‐inflammatory and Analgesic Activity

  2017cites this paper
• Anti-inflammatory, Analgesic and Anti-ulcerogenic Activities of Novel bis-thiadiazoles, bis-thiazoles and bis-formazanes.

  2017cites this paper
• Coumarinyl pyranopyrimidines as new neuropeptide S receptor antagonists; design, synthesis, homology and molecular docking.

  2017cites this paper
• An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation

  2017cites this paper
• Coumarins scaffolds as COX inhibitors.

  2017cites this paper
• Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate

  2017cites this paper
• 7-Hydroxycoumarin prevents UVB-induced activation of NF-κB and subsequent overexpression of matrix metalloproteinases and inflammatory markers in human dermal fibroblast cells.

  2016cites this paper
• Evaluation of anti-inflammatory effect of derivative (E)-N-(4-bromophenyl)-2-(thiophen-2-ylmethylene)-thiosemicarbazone.

  2016cites this paper