Microwave -Assisted Extraction of Sweet Lime Peel and Quantification of its Bio-Actives using HRLC-MS/MS

Citrus limetta, often known as sweet lime, is one of India's most important crops due to its high demand in the agro-processing industry. Peel of Citrus limetta has significant levels of polyphenolic chemicals that have pharmacological effects. In current study, the peel is valued for the bioactive compounds it contains. The total phenolic content (TPC) was 16.66mg GAE/g with an extraction yield of 12.91%. Radical scavenging activity (RSA) was 78.05%, total flavanoid content (TFC) was 9.59mg QE/g, and total phenolic content (TPC) was 9.59 mg QE/g. Sweet lime peel (SLP) extract was obtained by microwave-assisted extraction (MAE) in methanol.LC-MS/MS results showed 18 flavonoid compounds along with polyphenols like rutin, curcumin diglucoside, carotenoid, coumeroic acid, coumaric acids, flavonoid-7-o-glycosides, and Gardenin B that embrace anticancer, antimicrobial, anti-inflammatory, and antitumor activity. This method uses Q-TOF LC/MS with Agilent MassHunter Profiler software to investigate bioactive components in sweet lime peel.

• Publication year

  2025

• Venue

  Research Journal of Pharmacy and Technology

• Publication date

  2025-03-27

• Fields of study

  Not labeled

• Identifiers
  DOI 10.52711/0974-360x.2025.00142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Retraction Note: Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice

  2023cited by this paper
• Anticancer Potential of Coumarin derivatives: A Review

  2022cited by this paper
• Cytogenetic and immunological efficacy of nicotiflorin and rutin combination on gamma irradiated rats

  2022cited by this paper
• Sinensetin protects against pulmonary fibrosis via inhibiting Wnt/β-Catenin signaling pathway.

  2022cited by this paper
• A Potential Anticancer Mechanism of Finger Root (Boesenbergia rotunda) Extracts against a Breast Cancer Cell Line

  2022cited by this paper
• Phytochemistry, Pharmacological Properties, and Recent Applications of Ficus benghalensis and Ficus religiosa

  2021cited by this paper
• The Antioxidant Effect of Curcumin and Rutin on Oxidative Stress Biomarkers in Experimentally Induced Periodontitis in Hyperglycemic Wistar Rats

  2021cited by this paper
• Review of synthesis of silver nanoparticles from different medicinal plants and their pharmacological activities

  2021cited by this paper
• Study on Flavonoid and Bioactivity Features of the Pericarp of Citri Reticulatae 'Chachi' During Storage

  2021cited by this paper
• Chemical constituents, ethnomedicinal uses, pharmacology, and toxicity of Dysphania ambrosioides (L.) Mosyakin & Clemants, formerly Chenopodium ambrosioides L.

  2021cited by this paper
• Major flavonoids from Psiadia punctulata produce vasodilation via activation of endothelial dependent NO signaling

  2020cited by this paper
• Influence of Substrate Binding Residues on the Substrate Scope and Regioselectivity of a Plant O‐Methyltransferase against Flavonoids

  2020cited by this paper
• Preliminary Phytochemical Analysis and Isolation and Identification of active principle components of petroleum ether extract from leaves of Lawsoniainermis L.

  2019cited by this paper
• Virtual screening of natural products to select compounds with potential anticancer activity.

  2019cited by this paper
• Effect of Extraction method and Solvents on yield and Antioxidant Activity of Certain Sudanese Medicinal Plant Extracts

  2019cited by this paper
• Polymethoxyflavones: Chemistry and Molecular Mechanisms for Cancer Prevention and Treatment

  2019cited by this paper
• Spectroscopic Analysis of Bioactive Components of Ichnocarpus frutescens R. Br.

  2018cited by this paper
• In Vivo Anti-diarrheal Activity of Methanolic Extract of Streblus asper Leaves Stimulating the Na+/K+-ATPase in Swiss Albino Rats

  2018cited by this paper
• Antioxidant Activity of Flaxseed (Linum usitatissimum L.) shell and Analysis of Its Polyphenol Contents by LC-MS/MS

  2018cited by this paper
• Evaluation of in vitro Antioxidant, Antibacterial and Anticancer activities of leaf extracts of Cleome rutidosperma

  2017cited by this paper
• Effect of extraction methods on yield, phytochemical constituents and antioxidant activity of Withania somnifera

  2017cited by this paper
• Chemistry and Pharmacology of Citrus sinensis.

  2016cited by this paper
• Antioxidant activity of Citrus fruits.

  2016cited by this paper
• Pharmacological Properties and Therapeutic Potential of Naringenin: A Citrus Flavonoid of Pharmaceutical Promise.

  2016cited by this paper
• Emerging Microwave Assisted Extraction (MAE) techniques as an innovative green technologies for the effective extraction of the active phytopharmaceuticals

  2015cited by this paper
• Isolation of Flavonoids and their Anticancer Activity from Sphaeranthus amaranthoides in A549 Cell Line

  2015cited by this paper
• Phytochemical and Cytotoxicity Analysis of Seeds and Leaves of Adenanthera pavonina

  2015cited by this paper
• Citrus Flavonoids and Human Cancers

  2015cited by this paper
• Docking Studies and Synthesis of Novel Flavones Screened for Biological Activities like Anticancer and Antioxidant Activity

  2015cited by this paper
• Important nutritional constituents, flavour components, antioxidant and antibacterial properties of Pleurotus sajor-caju

  2014cited by this paper
• Evaluation of Free Radical Scavenging Activity of Various Leaf Extracts fromKedrostis foetidissima (Jacq.) Cogn.

  2014cited by this paper
• Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type.

  2012cited by this paper
• Phytochemical characterization and antimicrobial activity of Curcuma xanthorrhiza Roxb.

  2012cited by this paper
• Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish.

  2011cited by this paper
• Biological Activities of Water and Ethanolic Extracts from Allium victorialis L. Mature Leaves

  2011cited by this paper
• Troglitazone inhibits vascular endothelial growth factor-induced angiogenic signaling via suppression of reactive oxygen species production and extracellular signal-regulated kinase phosphorylation in endothelial cells.

  2009cited by this paper
• Inhibitory effect of phenolic acids on the proliferation of 3T3-L1 preadipocytes in relation to their antioxidant activity.

  2006cited by this paper
• A citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice.

  2004cited by this paper
• Superoxide radical scavenging activity of the major polyphenols in fresh plums.

  2003cited by this paper
• The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals

  1999cited by this paper

• No citing papers are available for this paper.