Engineering advanced bacterial therapy for tumor and inflammatory diseases.

Bacteria have emerged as a promising living medicine for diseases in recent years. With rapid advancements in synthetic biology and materials science, engineered bacterial therapy has encountered new opportunities. Leveraging inherent genetic reprogramming capabilities and surface chemistry modification advantages, engineered bacterial therapy enables selective functional recombination and precise spatiotemporal control, thereby enhancing therapeutic efficacy against diseases. This review summarizes the advantages of engineered bacterial therapy and various engineering strategies employed. Moreover, it outlines representative studies of engineered bacterial therapy in the treatment of tumors and inflammatory diseases, summarizing diverse engineered approaches that enhance the efficacy for these conditions, offering novel avenues for efficient disease management. In addition, current limitations and challenges in utilizing engineered bacterial therapy are discussed, providing insights for further innovation in biomedicine. Specifically, the potential and prospects of oral engineered bacteria in treating gastrointestinal tumors and inflammatory diseases have been explored.

• Publication year

  2025

• Venue

  International journal of pharmaceutics

• Publication date

  2025-04-01

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1016/j.ijpharm.2025.125585PMID 40216039
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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