Use of Lipid-Based Nanoparticles for the Treatment of Glioblastoma Multiform; A Review

A malignant brain tumor with a dismal prognosis and few available treatments is glioblastoma multiforme (GBM). The blood-brain barrier (BBB) poses challenges for therapeutic agents reaching the tumor site. Lipid-based nanoparticles (LBNPs) have emerged as a promising solution to get better outcomes in GBM therapy. LBNPs include liposomes, lipid nanoparticles (LNP), solid lipid nanoparticles (SLPs), lipid Nano emulsion (LNE), and nanostructured lipid carrier (NLC). The compromised BBB restricts the amount of medication that can flow through it and prevents it from reaching the tumor location. This review discusses the status of LNPs in GBM treatment, their types, and mechanisms of action, advantages and challenges, including toxicity, reproducibility and targeting ability. The review also explores the combination of LNPs with radiation therapy and immunotherapy to enhance therapy results.

• Publication year

  2025

• Venue

  Physical Education, Health and Social Sciences

• Publication date

  2025-03-24

• Fields of study

  Not labeled

• Identifiers
  DOI 10.63163/jpehss.v3i1.222
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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