Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells

Graphical abstract

• Publication year

  2025

• Venue

  Journal of Advanced Research

• Publication date

  2025-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jare.2025.04.033PMID 40288674PMCID 12869237
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CAPG is a novel biomarker for early gastric cancer and is involved in the Wnt/β-catenin signaling pathway

  2024cited by this paper
• Advancements and Obstacles of PARP Inhibitors in Gastric Cancer

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• Cancer statistics, 2023

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• A comprehensive insight into the correlation between ncRNAs and the Wnt/β-catenin signalling pathway in gastric cancer pathogenesis

  2023cited by this paper
• DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review

  2022cited by this paper
• CircRNAs in gastric cancer: current research and potential clinical implications

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• Biomarkers for Gastric Cancer Screening and Early Diagnosis

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• PARP inhibitors in gastric cancer: beacon of hope

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• Targeting circular RNAs as a therapeutic approach: current strategies and challenges

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• A Brief Review of circRNA Biogenesis, Detection, and Function

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• Review on circular RNAs and new insights into their roles in cancer

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• The expanding regulatory mechanisms and cellular functions of circular RNAs

  2020cited by this paper
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• Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice

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• RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo.

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• Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

  2019cited by this paper
• Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression

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• Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation

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  2017cited by this paper
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• Effectiveness of the Korean National Cancer Screening Program in Reducing Gastric Cancer Mortality.

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• Gastric cancer

  2016cited by this paper
• Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses

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• Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer.

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• Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.

  2005cited by this paper
• Poly(ADP-Ribose) Polymerase-1 Is a Component of the Oncogenic T-Cell Factor-4/β-Catenin Complex

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• ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

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• Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response.

  2004cited by this paper
• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

  2003influential reference
• The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells.

  2002cited by this paper
• beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer.

  2002cited by this paper
• Chromosomal stability and the DNA double-stranded break connection

  2001cited by this paper
• ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks*

  2001cited by this paper
• Early Embryonic Lethality in PARP-1 AtmDouble-Mutant Mice Suggests a Functional Synergy in Cell Proliferation during Development

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• Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures.

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• Potato spindle tuber "virus". IV. A replicating, low molecular weight RNA.

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• Noncoding RNAs: A Novel Frontier in Liver Cancer Research and Therapy: Implications for Precision Oncology.

  2026cites this paper
• Exploring the molecular pathology and tumor microenvironment in gastric cancer liver metastasis

  2026cites this paper
• Circular RNA circAHSA1 serves as a stable serum biomarker for the diagnosis and progression of gastric cancer

  2025cites this paper