Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses

No abstract is available for this paper.

• Publication year

  2016

• Venue

  European Heart Journal

• Publication date

  2016-02-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/eurheartj/ehw001PMID 26873092
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis

  2016cited by this paper
• Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors

  2015cited by this paper
• Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels.

  2015cited by this paper
• The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4

  2015cited by this paper
• Exon-intron circular RNAs regulate transcription in the nucleus

  2015cited by this paper
• The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs

  2014cited by this paper
• Detecting and characterizing circular RNAs

  2014cited by this paper
• miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7

  2014cited by this paper
• Methods of cellular senescence induction using oxidative stress.

  2013cited by this paper
• Natural RNA circles function as efficient microRNA sponges

  2013cited by this paper
• Up-regulation of alpha-smooth muscle actin in cardiomyocytes from non-hypertrophic and non-failing transgenic mouse hearts expressing N-terminal truncated cardiac troponin I☆

  2013cited by this paper
• Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7 and vimentin in different signal pathways

  2013cited by this paper
• miRNA-205 Suppresses Melanoma Cell Proliferation and Induces Senescence via Regulation of E2F1 Protein*

  2011cited by this paper
• Four faces of cellular senescence

  2011cited by this paper
• Downregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling and induces senescence in papillary thyroid carcinoma cells

  2011cited by this paper
• Accelerated DNA replication in E2F1- and E2F2-deficient macrophages leads to induction of the DNA damage response and p21CIP1-dependent senescence

  2010cited by this paper
• MicroRNA MiR-17 retards tissue growth and represses fibronectin expression

  2009cited by this paper
• Induction of human endometrial cancer cell senescence through modulation of HIF‐1α activity by EGLN1

  2006cited by this paper
• Id family of helix-loop-helix proteins in cancer

  2005cited by this paper
• Id family of helix-loop-helix proteins in cancer

  2005cited by this paper
• Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

  2001cited by this paper
• Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy.

  2001cited by this paper
• Id-1 delays senescence but does not immortalize keratinocytes.

  2000cited by this paper
• Tandem Repeats Are Involved in G1 Domain Inhibition of Versican Expression and Secretion and the G3 Domain Enhances Glycosaminoglycan Modification and Product Secretion via the Complement-binding Protein-like Motif*

  2000cited by this paper
• Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells.

  2000cited by this paper
• Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation.

  1991cited by this paper
• Telomeres shorten during ageing of human fibroblasts

  1990cited by this paper

• Cigarette smoke-induced circFOXO3 upregulation enhances autophagy-regulated senescence of type II alveolar cells through interacting with E2F1

  2026influential citation
• Metabolic Adaptation and Pulmonary ceRNA Network Plasticity in Orientallactaga sibirica During Water Deprivation Stress

  2026cites this paper
• The role of circular RNAs in mediating the protective effects of exercise against muscle degeneration and aging

  2026cites this paper
• The circular RNA landscape: Biogenesis, functions, identification pipelines, and biomedical applications

  2026cites this paper
• Emerging roles of circular RNAs and enhancer RNAs: new insights into the development and management of neurodegenerative disorders

  2026cites this paper
• Circular RNAs: Unlocking new avenues in cardiometabolic disease management.

  2026cites this paper
• Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1

  2026cites this paper
• circPTPRM can encode a functional polypeptide circPTPRM-187aa to promote papillary thyroid carcinoma progression.

  2026cites this paper
• Circ-FoxO3 alleviates APOE4-induced brain pathology through FoxO3-mediated autophagy

  2026cites this paper
• Exercise and the hallmarks of cardiovascular aging.

  2026cites this paper
• Neuroendocrine-associated epigenetic factors in cellular senescence: mechanisms and therapeutic implications

  2026cites this paper
• CRISPR/Cas13a trans-Cleavage-Driven Programmable Autonomous Synthesis of a Functional G-Quadruplex for Ultrasensitive Detection of Circular RNAs with an Improved Signal-to-Background Ratio.

  2025cites this paper
• Biomaterial-based circular RNA therapeutic strategy for repairing intervertebral disc degeneration

  2025cites this paper
• Decoding noncoding RNAs in regulating cardiovascular aging and age-related conditions: the emerging landscape

  2025cites this paper
• The diagnostic and therapeutic potential of multiple myeloma-associated circular RNAs.

  2025cites this paper
• Regulation of pyroptosis in diabetic nephropathy by long non-coding and circular RNAs

  2025cites this paper
• A new protein isoform encoded by human circular RNA circSLC8a1 contributes to cardiac remodelling

  2025cites this paper
• Circular RNA biomarkers in acute myeloid leukemia.

  2025cites this paper
• Circular RNAs in Organ Fibrosis.

  2025cites this paper
• Therapeutic Potential of Circular RNAs as Targets for Cancer Treatment

  2025cites this paper
• The biological function and mechanism of action of circRNA as a potential target in colorectal cancer.

  2025cites this paper
• Research progress of circular RNA and N6-methyladenosine modification in colorectal cancer.

  2025cites this paper
• Landscape of non-coding RNAs in cancer treatment-induced cardiovascular toxicity: from mechanistic insights to clinical implications.

  2025cites this paper
• Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells

  2025cites this paper
• Epigenetic Regulation of Cellular Senescence in Gastrointestinal Cancer.

  2025cites this paper
• Unlocking the potential of circular RNA vaccines: a bioinformatics and computational biology perspective

  2025cites this paper
• Circular RNAs and endothelial dysfunction: mechanistic crosstalk and emerging therapeutic perspectives

  2025cites this paper
• Challenges and Future Prospectives in Circular RNA Investigation.

  2025cites this paper
• Circular RNAs in Cardiovascular Physiopathology: From Molecular Mechanisms to Therapeutic Opportunities

  2025cites this paper
• Circular RNAs in Cardiovascular Disease: Mechanisms, Biomarkers, and Therapeutic Frontiers

  2025cites this paper
• Circular RNAs Binding to RNA-Binding Proteins.

  2025cites this paper
• Circular RNAs: A Potential Regulator in Environmental Chemical Carcinogenesis.

  2025cites this paper
• A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis

  2025cites this paper
• A Review on Circular RNA Translation and Its Implications in Disease.

  2025cites this paper
• Targeting circFOXO3 to Modulate Integrin β6 Expression in Periodontitis: A Potential Therapeutic Approach.

  2025cites this paper
• Role of noncoding RNA and protein interaction in pancreatic cancer

  2025cites this paper
• Senescence-related circRNA circHIF-1α is associated with pancreatic cancer progression

  2025cites this paper
• Circular RNAs: driving forces behind chemoresistance and immune evasion in bladder cancer

  2025cites this paper
• Mechanisms of Circular RNAs in Breast Cancer Progress: A Special Attention to hsa_circ_000839 and hsa_circ_0005986 as Novel Biomarkers

  2025cites this paper
• Emerging role of circular RNAs in gastric cancer: From basic biology to clinical applications (Review)

  2025cites this paper
• Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1

  2025cites this paper
• Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression

  2025cites this paper
• The immunomodulatory roles of endogenous circular RNAs: Biogenesis, function, and therapeutic exploitation.

  2025cites this paper
• FoxO3 Activation Alleviates Doxorubicin‐Induced Cardiomyopathy by Enhancing Autophagic Flux and Suppressing mTOR/ROS Signalling

  2025cites this paper
• Circular RNAs in Heart Diseases.

  2025cites this paper
• Dysfunctional circular RNA network in major depressive disorder: dissecting the cell identity and potential clinical applications

  2025cites this paper
• CircRNAs—Potential Diagnostic Biomarkers and Therapeutic Targets for Receptive and Cancerous Endometrium

  2025cites this paper
• PYRCR alleviates myocardial ischemia/reperfusion injury in mice via inhibiting DRG2-mediated cardiomyocyte pyroptosis

  2025cites this paper
• Regulatory role of circRNAs in mammalian pregnancy.

  2025cites this paper
• Deciphering the multifaceted role of circular RNA in aging: from molecular mechanisms to therapeutic potentials

  2025cites this paper
• Novel Truncated Peptide Derived From circCDYL Exacerbates Cardiac Hypertrophy

  2025cites this paper
• noRBM24-mediated biogenesis of circ23679 protects cardiomyocytes against apoptosis via sponging miR-15b-5p.

  2025cites this paper
• Interconnected Pathways and Therapeutic Implications for Cardiovascular Aging and Diseases

  2025cites this paper
• The Role of the Fox Gene in Breast Cancer Progression

  2025cites this paper
• Circulating Non-Coding RNAs as Indicators of Fibrosis and Heart Failure Severity

  2025cites this paper
• Exploring the role of circular RNAs in endometrial cancer progression and chemoresistance: Implications for targeted therapies

  2025influential citation
• Role of Circular RNAs in Regulating Toxicity Induced by Cancer Therapies

  2025cites this paper
• Quercetin alleviates ethanol-induced hepatocyte senescence by interacting with glycinamide ribonucleotide transformylase.

  2025cites this paper
• Exploring the frontier of non-coding RNAs: biogenesis, functional diversity, and disease associations of circRNAs and tinyRNAs

  2025cites this paper
• Cardiac Aging: Molecular Mechanisms and Therapeutic Interventions.

  2025cites this paper
• Circular RNA Rftn1 Promotes Cardiac Hypertrophy In Vitro and In Vivo by Sponging miRNA‐1192 to Upregulate Tripartite Motif Protein 25 and 41

  2025cites this paper
• Circular RNAs orchestrating breast cancer hallmarks: bridging tumor biology and therapy resistance

  2025cites this paper
• Non-coding RNAs in cancer therapy-induced cardiotoxicity: Unlocking precision biomarkers for early detection.

  2025cites this paper
• Natural Products From Traditional Chinese Medicine: Potential Therapeutic Agents in Cancer Therapy-Induced Cardiotoxicity

  2025cites this paper
• Circular RNAs at the crossroads of acute pancreatitis: bridging molecular mechanisms to diagnostic and therapeutic innovations

  2025cites this paper
• Inhibition of circDGKZ ameliorates myocardial ischemia/reperfusion injury by targeting miR‐345‐5p/TLR4

  2024cites this paper
• Emerging roles of circular RNAs in nasopharyngeal carcinoma: functions and implications

  2024cites this paper
• Circ_0004592: An auxiliary diagnostic biomarker for gastric cancer

  2024cites this paper
• Bibliometric analysis of the research hotspots and trends of circular RNAs

  2024cites this paper
• Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival

  2024cites this paper
• Non‐coding RNAs and their potential exploitation in cancer therapy‐related cardiotoxicity

  2024influential citation
• Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome.

  2024cites this paper
• CircUGGT2 facilitates progression and cisplatin resistance of bladder cancer through nonhomologous end-joining pathway.

  2024cites this paper
• Riddle of the Sphinx: Emerging role of circular RNAs in cervical cancer.

  2024cites this paper
• Dysregulated Expression Patterns of Circular RNAs in Cancer: Uncovering Molecular Mechanisms and Biomarker Potential

  2024cites this paper
• Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus

  2024cites this paper
• Advanced approaches of the use of circRNAs as a replacement for cancer therapy

  2024cites this paper
• Subcellular localization of circular RNAs: Where and why.

  2024cites this paper
• Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization

  2024cites this paper
• TEA domain transcription factor 1 (TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway

  2024cites this paper
• Circular RNA circVmn2r1 acts as a miR-223-3p sponge to promote kidney aging by regulating NLRP3 expression in mice.

  2024cites this paper
• Potential regulatory role of epigenetic modifications in aging-related heart failure.

  2024cites this paper
• Unlocking the Dark Matter: Noncoding RNAs and RNA Modifications in Cardiac Aging.

  2024cites this paper
• Exosomes secreted by Fusobacterium nucleatum-infected colon cancer cells transmit resistance to oxaliplatin and 5-FU by delivering hsa_circ_0004085

  2024cites this paper
• CircABCB10 Promotes the Apoptosis and Inflammatory Response of 16HBE Cells by Cigarette Smoke Extract by Targeting miR-130a/PTEN Axis

  2024cites this paper
• Multi-resolution sequence and structure feature extraction for binding site prediction

  2024cites this paper
• Molecular mechanisms of circular RNA translation

  2024cites this paper
• The role of cellular senescence in profibrillatory atrial remodeling associated with cardiac pathology.

  2024cites this paper
• Circular RNA-mediated miRNA sponge & RNA binding protein in biological modulation of breast cancer

  2024cites this paper
• Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction

  2024cites this paper
• CircAge: A Comprehensive Resource for Aging-associated Circular RNAs Across Species and Tissues

  2024cites this paper
• Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis

  2024cites this paper
• Research progress of circular RNA FOXO3 in diseases (review)

  2024cites this paper
• Circular RNAs: history, metabolism, mechanisms of function, and regulatory roles at a glance

  2024cites this paper
• Circular RNAs in coronary heart disease: From molecular mechanism to promising clinical application (Review)

  2024cites this paper
• Circular RNA and its potential diagnostic and therapeutic values in breast cancer

  2024cites this paper
• The Role of Circular RNA Variants Generated from the NFIX Gene in Different Diseases.

  2024cites this paper
• Expanding roles of circRNAs in cardiovascular diseases

  2024cites this paper
• A programmable quantum dot nanosensor guided by three-way junction skeleton-mediated cascade signal amplification for sensitive detection of circRNAs in breast cancer

  2024cites this paper
• The clinical perspective of circular RNAs in neurodegenerative diseases: potential diagnostic tools and therapeutic targets

  2024cites this paper