SCIENCE@home

A Minimal Genetic Circuit for Cellular Anticipation

Jordi Pla-Mauri,Ricard V. Solé

Published 2025 in bioRxiv

ABSTRACT

Living systems have evolved cognitive complexity to reduce environmental uncertainty, enabling them to predict and prepare for future conditions. Anticipation, distinct from simple prediction, involves active adaptation before an event occurs and is a key feature of both neural and aneural biological agents. Building on the moving average convergence–divergence principle from financial trend analysis, we propose an implementation of anticipation through synthetic biology by designing and evaluating experimentally testable minimal genetic circuits capable of anticipating environmental trends. Through deterministic and stochastic analyses, we demonstrate that these motifs achieve robust anticipatory responses under a wide range of conditions. Our findings suggest that simple genetic circuits could be naturally exploited by cells to prepare for future events, providing a foundation for engineering predictive biological systems.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-59 of 59 references · Page 1 of 1

CITED BY