Regulating Intratumoral Fungi With Hydrogels: A Novel Approach to Modulating the Tumor Microbiome for Cancer Therapy

Fungi in tumors act as a double‐edged sword, potentially worsening or alleviating malignancy based on the ecological balance within the tumor microenvironment (TME). Hydrogels, as innovative drug delivery systems, are poised to redefine treatment paradigms. As advanced biomaterials, they offer a versatile platform for encapsulating and releasing antifungal agents and immunomodulators, responding to the TME's unique demands.

• Publication year

  2025

• Venue

  Cancer Medicine

• Publication date

  2025-04-30

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1002/cam4.70900PMID 40304214PMCID 12041943
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Injectable, Biodegradable and Photothermal Hydrogel with Quorum Sensing Inhibitory Effects for Subcutaneous Fungal Infection Treatment.

  2025cited by this paper
• Intratumoural microbiota: a new frontier in cancer development and therapy

  2024cited by this paper
• 3D Printable Alginate–Chitosan Hydrogel Loaded With Ketoconazole Exhibits Anticryptococcal Activity

  2024cited by this paper
• A smart DNA hydrogel for isolation of bacterial outer membrane vesicles and localized cancer immunotherapy

  2024cited by this paper
• Fungal Enzyme‐Responsive Hydrogel Drug Delivery Platform for Triggered Antifungal Release

  2024cited by this paper
• Cisplatin-activated and hemoglobin-mediated injectable hydrogel system for antitumor chemodynamic and chemotherapy.

  2024cited by this paper
• Increasing Chemotherapeutic Efficacy Using pH Modulating and Doxorubicin Releasing Injectable Chitosan-Polyethylene Glycol Hydrogels

  2023cited by this paper
• The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells.

  2023cited by this paper
• Injectable Supramolecular Hydrogels for In Situ Programming of Car‐T Cells toward Solid Tumor Immunotherapy

  2023cited by this paper
• Injectable Zwitterionic Physical Hydrogel with Enhanced Chemodynamic Therapy and Tumor Microenvironment Remodeling Properties for Synergistic Anticancer Therapy.

  2023cited by this paper
• Multimodal metagenomic analysis reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer

  2023cited by this paper
• Immunostimulant Hydrogel-Guided Tumor Microenvironment Reprogramming to Efficiently Potentiate Macrophage-Mediated Cellular Phagocytosis for Systemic Cancer Immunotherapy.

  2023cited by this paper
• Enrichment and sensing tumor cells by embedded immunomodulatory DNA hydrogel to inhibit postoperative tumor recurrence

  2023cited by this paper
• Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword

  2023cited by this paper
• It's all relative: analyzing microbiome compositions, its significance, pathogenesis and microbiota derived biofilms: Challenges and opportunities for disease intervention

  2023cited by this paper
• Fungi and cancer

  2023cited by this paper
• Location and condition based reconstruction of colon cancer microbiome from human RNA sequencing data

  2023cited by this paper
• The intratumour microbiota and neutrophilic inflammation in squamous cell vulvar carcinoma microenvironment

  2023cited by this paper
• Immunosuppressive microenvironment improvement and treatment of aggressive malignancy pancreatic ductal adenocarcinoma based on local administration of injectable hydrogel

  2023cited by this paper
• Hydrogels for RNA delivery

  2023cited by this paper
• Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer

  2023cited by this paper
• Bioresponsive Self‐Reinforcing Sericin/Silk Fibroin Hydrogel for Relieving the Immune‐Related Adverse Events in Tumor Immunotherapy

  2023cited by this paper
• Current understanding of the intratumoral microbiome in various tumors

  2023cited by this paper
• Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer.

  2022cited by this paper
• Emerging roles of intratumor microbiota in cancer metastasis.

  2022cited by this paper
• Intratumoral bacteria are an important "accomplice" in tumor development and metastasis.

  2022cited by this paper
• Microbiota in a long survival discourse with the human host

  2022cited by this paper
• Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

  2022cited by this paper
• A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors.

  2022cited by this paper
• Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions

  2022cited by this paper
• The tumor mycobiome: A paradigm shift in cancer pathogenesis.

  2022cited by this paper
• Nanoenzyme-chitosan hydrogel complex with cascade catalytic and self-reinforced antibacterial performance for accelerated healing of diabetic wounds.

  2022cited by this paper
• Fusobacterium nucleatum and Bacteroides fragilis detection in colorectal tumours: Optimal target site and correlation with total bacterial load

  2022cited by this paper
• Metallo-alginate hydrogel can potentiate microwave tumor ablation for synergistic cancer treatment

  2022cited by this paper
• Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science

  2022cited by this paper
• Spatial meta-transcriptomics reveal associations of intratumor bacteria burden with lung cancer cells showing a distinct oncogenic signature

  2022cited by this paper
• Progress in the mechanical enhancement of hydrogels: Fabrication strategies and underlying mechanisms

  2022cited by this paper
• Analysis of the Pancreatic Cancer Microbiome Using Endoscopic Ultrasound–Guided Fine-Needle Aspiration–Derived Samples

  2022cited by this paper
• Hydrogel-based co-delivery of CIK cells and oncolytic adenovirus armed with IL12 and IL15 for cancer immunotherapy.

  2022cited by this paper
• Correction to: “Molding” immunity—modulation of mucosal and systemic immunity by the intestinal mycobiome in health and disease

  2022cited by this paper
• Spermine Modified PNIPAAm Nano-Hydrogel Serving as Thermo-Responsive System for Delivery of Cisplatin

  2022cited by this paper
• Thermosensitive Tri-Block Polymer Nanoparticle-Hydrogel Composites as Payloads of Natamycin for Antifungal Therapy Against Fusarium Solani

  2022cited by this paper
• Tackling the emerging threat of antifungal resistance to human health

  2022cited by this paper
• An easy-to-use antimicrobial hydrogel effectively kills bacteria, fungi, and influenza virus.

  2022cited by this paper
• Distinct bronchial microbiome precedes clinical diagnosis of lung cancer

  2022cited by this paper
• Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

  2021cited by this paper
• Research Progress of Thermosensitive Hydrogel in Tumor Therapeutic

  2021cited by this paper
• The microbiome(s) and cancer: know thy neighbor(s)

  2021cited by this paper
• The microbiome and human cancer

  2021cited by this paper
• Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver.

  2021cited by this paper
• Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer

  2021cited by this paper
• Cancer Cell-Sticky Hydrogels to Target the Cell Membrane of Invading Glioblastomas.

  2021cited by this paper
• Fungi, Host Immune Response and Tumorigenesis.

  2021cited by this paper
• Prognostic correlations with the microbiome of breast cancer subtypes

  2021cited by this paper
• Microbiome and cancer.

  2021cited by this paper
• A microenvironment-inspired synthetic 3D model for pancreatic ductal adenocarcinoma organoids

  2021cited by this paper
• The intratumoral microbiome: Characterization methods and functional impact.

  2021cited by this paper
• Role of biliary stent and neoadjuvant chemotherapy in the pancreatic tumor microbiome

  2021cited by this paper
• The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?

  2021cited by this paper
• Fusobacterium nucleatum predicts a high risk of metastasis for esophageal squamous cell carcinoma

  2021cited by this paper
• Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma

  2021cited by this paper
• Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors

  2021cited by this paper
• The Emerging Role of Microbiota and Microbiome in Pancreatic Ductal Adenocarcinoma

  2020cited by this paper
• Carbon dots-releasing hydrogels with antibacterial activity, high biocompatibility, and fluorescence performance as candidate materials for wound healing.

  2020cited by this paper
• A Microbiota-Derived Metabolite Augments Cancer Immunotherapy Responses in Mice.

  2020cited by this paper
• The human tumor microbiome is composed of tumor type–specific intracellular bacteria

  2020cited by this paper
• Regulation and modulation of antitumor immunity in pancreatic cancer

  2020cited by this paper
• Overview of the Potential Role of Malassezia in Gut Health and Disease

  2020cited by this paper
• Interaction between microbiota and immunity in health and disease

  2020cited by this paper
• Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

  2020cited by this paper
• Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

  2020cited by this paper
• Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling

  2020cited by this paper
• Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction

  2020cited by this paper
• The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View

  2020cited by this paper
• The microbiome, cancer, and cancer therapy

  2019cited by this paper
• Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.

  2019cited by this paper
• Delivery technologies for cancer immunotherapy

  2019cited by this paper
• Systemic infection with Candida albicans in breast tumor bearing mice: Cytokines dysregulation and induction of regulatory T cells.

  2019cited by this paper
• Endogenous murine microbiota member Faecalibaculum rodentium and its human homolog protect from intestinal tumor growth

  2019cited by this paper
• Hydrogel-based controlled drug delivery for cancer treatment: a review.

  2019cited by this paper
• Current challenges and best-practice protocols for microbiome analysis

  2019cited by this paper
• Gut Microbiota and Obesity: A Role for Probiotics

  2019cited by this paper
• The Fungal Mycobiome Promotes Pancreatic Oncogenesis via MBL Activation

  2019cited by this paper
• Temperature and pH-responsive nano-hydrogel drug delivery system based on lysine-modified poly (vinylcaprolactam)

  2019cited by this paper
• Whole-body hyperthermia in combination with systemic therapy in advanced solid malignancies.

  2019cited by this paper
• Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance

  2019cited by this paper
• Interplay between the human gut microbiome and host metabolism

  2019cited by this paper
• The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression.

  2018cited by this paper
• Nanomaterials for Cancer Precision Medicine

  2018cited by this paper
• Controlled drug delivery vehicles for cancer treatment and their performance

  2018cited by this paper
• Hypoxia and acidosis: immune suppressors and therapeutic targets

  2018cited by this paper
• Silver sulfadiazine nanosuspension-loaded thermosensitive hydrogel as a topical antibacterial agent

  2018cited by this paper
• Monospecies and polymicrobial biofilms differentially regulate the phenotype of genotype-specific oral cancer cells

  2018cited by this paper
• Antibacterial Hydrogels

  2018cited by this paper
• Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

  2018cited by this paper
• Engineered Hydrogels in Cancer Therapy and Diagnosis.

  2017cited by this paper
• The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease.

  2017cited by this paper
• The future of biology in driving the field of hyperthermia

  2016cited by this paper
• Epidemiologic studies of the human microbiome and cancer

  2016cited by this paper
• Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy.

  2016cited by this paper

• No citing papers are available for this paper.