Evidence of a role of tumor necrosis factor alpha in refractory asthma.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  New England Journal of Medicine

• Publication date

  2006-02-16

• Fields of study

  Medicine

• Identifiers
  DOI 10.1056/NEJMOA050580PMID 16481637
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of tumor necrosis factor antagonism on allergen-mediated asthmatic airway inflammation.

  2005cited by this paper
• Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma.

  2005cited by this paper
• Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma

  2005cited by this paper
• Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17).

  2004cited by this paper
• Evaluation of the Contribution of Different ADAMs to Tumor Necrosis Factor α (TNFα) Shedding and of the Function of the TNFα Ectodomain in Ensuring Selective Stimulated Shedding by the TNFα Convertase (TACE/ADAM17)*

  2004cited by this paper
• The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma

  2003cited by this paper
• Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.

  2002cited by this paper
• Mast-cell infiltration of airway smooth muscle in asthma.

  2002cited by this paper
• TNF-alpha dysregulation in asthma: relationship to ongoing corticosteroidtherapy.

  2000cited by this paper
• Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?

  2000cited by this paper
• Increased expression of functionally active membrane-associated tumor necrosis factor in acute respiratory distress syndrome.

  2000cited by this paper
• Tumour necrosis factor-alpha production in human alveolar macrophages: modulation by inhaled corticosteroid.

  2000cited by this paper
• Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society.

  2000cited by this paper
• TNF-α Dysregulation in Asthma: Relationship to Ongoing Corticosteroid Therapy

  2000cited by this paper
• Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics.

  1999cited by this paper
• Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor.

  1999cited by this paper
• Airway remodeling and repair.

  1999cited by this paper
• Costs of asthma according to the degree of severity.

  1998cited by this paper
• Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force.

  1997cited by this paper
• A membrane TNF-alpha/TNFR ratio correlates to MODS score and mortality.

  1996cited by this paper
• Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects.

  1995cited by this paper
• Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

  1994cited by this paper
• Measuring quality of life in asthma.

  1993cited by this paper
• Cytokines in symptomatic asthma airways.

  1992cited by this paper
• Tumor necrosis factor causes bronchial hyperresponsiveness in rats.

  1992cited by this paper
• Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

  1990cited by this paper
• A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF.

  1988cited by this paper
• The active form of tumor necrosis factor is a trimer.

  1987cited by this paper
• Structure of human tumor necrosis factor alpha derived from recombinant DNA.

  1987cited by this paper

• Increased Orexin by High Concentration of Sevoflurane Enhances the Suprahyoid Muscle Activity Involves in Gasping‐Like Respiration of Mice

  2026cites this paper
• Therapeutic potential of targeting novel signaling pathways in regulating chronic inflammation in obstructive lung disorders.

  2026cites this paper
• Cytokine storm

  2026cites this paper
• Asthma in Patients With Confirmed Pulmonary Sarcoidosis

  2026cites this paper
• Biologics in Asthma: A Paradigm Shift in Treatment for Severe Asthma Patients

  2026cites this paper
• Identification of NLRP3 and TIPE2 as asthma biomarkers via integrative bioinformatics and Mendelian randomization

  2026cites this paper
• GLCCI1 alleviates airway remodeling in asthmatic mice by inhibiting ZEB1-mediated epithelial-mesenchymal transition

  2026cites this paper
• Indoor Rewilding of Laboratory Mice Recalibrates Pulmonary Mucosal Immunity and Mechanics

  2026cites this paper
• Potential diagnostic markers and therapeutic targets for major depressive disorder based on bioinformatics analysis and molecular docking studies

  2025cites this paper
• Systemic inflammatory biomarkers in relation to lung function and exercise‐induced bronchoconstriction in adolescents

  2025cites this paper
• Anti-cytokine biologics for asthma in adults.

  2025cites this paper
• FRONTIER-3: a randomised phase 2a study to investigate tozorakimab, an anti-interleukin-33 monoclonal antibody, in early-onset asthma

  2025cites this paper
• IL-13 Modulates Antiviral Effector and Proinflammatory Pathways in Rhinovirus-Infected Pediatric Bronchial Epithelium

  2025cites this paper
• Asthma Biologics Across the T2 Spectrum of Inflammation in Severe Asthma: Biomarkers and Mechanism of Action

  2025cites this paper
• Biomarkers of Oxidative Stress, Systemic Inflammation and Thrombosis in Adult Asthmatic Patients Treated with Inhaled Corticosteroids During Exposure to Fine Particulate Matter

  2025cites this paper
• Established and Emerging Asthma Biomarkers with a Focus on Biologic Trials: A Narrative Review

  2025cites this paper
• Saposhnikovia divaricata-Fructus mume herb pair alleviates airway inflammation in asthma by inhibiting IL-17 secretion from γδT17 cells via the Notch1 signaling pathway.

  2025cites this paper
• Exploring TNFR1: from discovery to targeted therapy development

  2025cites this paper
• Tumor necrosis factor receptor 2 in allergen tolerance: a perspective view

  2025cites this paper
• Novel insights into asthma pathophysiology and pharmacological interventions: spiral of respiratory symptoms and psychiatric episodes

  2025cites this paper
• Methacholine Challenge: Physiology, Methodology, and Clinical Interpretation.

  2025cites this paper
• Causal association between circulating cytokine levels and the risk for asthma: A bidirectional, Mendelian randomization study

  2025cites this paper
• Breaking the steroid barrier: Emerging biomarkers and targeted therapies for type 2-low asthma

  2025cites this paper
• Analysis of Selected Serum Cytokines to Evaluate the Early Efficacy of Benralizumab, Dupilumab, and Mepolizumab in Severe Eosinophilic Asthma Treatment

  2025cites this paper
• Phenotype Overlap and Lung Function in Childhood Asthma: The Interaction Between T2 and Non‐T2 Responses

  2025cites this paper
• New targets for type 2-low asthma

  2024cites this paper
• Research progress in the clinical application of inhaled anesthetic sevoflurane

  2024cites this paper
• Ion Channels in the Immune Response of Asthma

  2024cites this paper
• Zinc Deficiency and Zinc Supplementation in Allergic Diseases

  2024cites this paper
• Ratio of plasma IL-13/TNF- ∝ and CXCL10/CCL17 predicts mepolizumab and omalizumab response in asthma better than eosinophil count or immunoglobulin E level

  2024cites this paper
• Association of Obesity and Severe Asthma in Adults

  2024cites this paper
• The Efficacy & Molecular Mechanisms of a Terpenoid Compound Ganoderic Acid C1 on Corticosteroid-Resistant Neutrophilic Airway Inflammation: In vivo and in vitro Validation.

  2024cites this paper
• Weighted Breaths: Exploring Biologic and Non-Biologic Therapies for Co-Existing Asthma and Obesity

  2024cites this paper
• Downregulation of otulin induces inflammasome activation in neutrophilic asthma.

  2024cites this paper
• Orally administered yeast‐derived β‐glucan alleviates mast cell‐dependent airway hyperresponsiveness and inflammation in a murine model of asthma

  2024cites this paper
• Nebulized Budesonide Prevents Airway Inflammation in Children with High Total IgE Levels After Open Heart Surgery with Cardiopulmonary Bypass: A Prospective Randomized Controlled Trial

  2024cites this paper
• Airway hyperresponsiveness in asthma: the role of the epithelium.

  2024cites this paper
• Human Host Defense Peptide LL-37 Suppresses TNFα-Mediated Matrix Metalloproteinases MMP9 and MMP13 in Human Bronchial Epithelial Cells

  2024cites this paper
• Group 3 Innate Lymphoid Cells: A Potential Therapeutic Target for Steroid Resistant Asthma

  2024cites this paper
• T cell and airway smooth muscle interaction: a key driver of asthmatic airway inflammation and remodelling.

  2024cites this paper
• Unraveling the Molecular Landscape of Neutrophil Extracellular Traps in Severe Asthma: Identification of Biomarkers and Molecular Clusters

  2024cites this paper
• Pediatric Obesity and severe asthma: targeting pathways driving inflammation.

  2023cites this paper
• Definition, Phenotyping of Severe Asthma, Including Cluster Analysis.

  2023cites this paper
• A portable and low-cost centrifugal microfluidic platform for multiplexed colorimetric detection of protein biomarkers.

  2023cites this paper
• Asthmatic lung fibroblasts promote type 2 immune responses via endoplasmic reticulum stress response dependent thymic stromal lymphopoietin secretion

  2023cites this paper
• Basis of preventive and non-pharmacological interventions in asthma

  2023cites this paper
• Feasibility of exercise therapy for children with asthma: a meta-analysis

  2023cites this paper
• Development of a free cytokine immunoassay to maintain binding and dissociation equilibrium in vitro.

  2023cites this paper
• Dual inhibition of airway inflammation and fibrosis by common beta cytokine receptor blockade.

  2023cites this paper
• Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells

  2023cites this paper
• A Comprehensive Analysis of Cytokine Network in Centenarians

  2023cites this paper
• Effect of Biologic Therapies on Airway Hyperresponsiveness and Allergic Response: A Systematic Literature Review

  2023cites this paper
• Effect of Obesity on Lung Function in the Pediatric and Adult Populations with Asthma: A Review

  2023cites this paper
• Mast Cells in Upper and Lower Airway Diseases: Sentinels in the Front Line

  2023cites this paper
• Trends of therapy in the treatment of asthma

  2023cites this paper
• Sex-Based Differences in Bronchial Asthma: What Are the Mechanisms behind Them?

  2023cites this paper
• Effects of Oxidative Stress on Airway Epithelium Permeability in Asthma and Potential Implications for Patients with Comorbid Obesity

  2023cites this paper
• New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis

  2023cites this paper
• Anti-Tumor Necrosis Factor for Supplementary Management in Severe Asthma: A Systematic Review and Meta-analysis

  2023influential citation
• Combination of IL-17A/F and TNF-α uniquely alters the bronchial epithelial cell proteome to enhance proteins that augment neutrophil migration

  2022cites this paper
• Thérapeutique immunologique ciblée dans l’asthme

  2022cites this paper
• Role of IL-22 in acute asthma mouse model

  2022cites this paper
• Sex Steroids Effects on Asthma: A Network Perspective of Immune and Airway Cells

  2022cites this paper
• Chronic allergic lung inflammation negatively influences neurobehavioral outcomes in mice

  2022cites this paper
• Neutrophils and Asthma

  2022cites this paper
• Therapeutic Potential of Combining IL-6 and TNF Blockade in a Mouse Model of Allergic Asthma

  2022cites this paper
• T2-low: What do we know? - Past, present, and future of biologic therapies in non-eosinophilic asthma.

  2022cites this paper
• Clinical Characteristics and Management Strategies for Adult Obese Asthma Patients

  2022cites this paper
• T-cell responses in asthma exacerbations.

  2022cites this paper
• The Interactions Between Autoinflammation and Type 2 Immunity: From Mechanistic Studies to Epidemiologic Associations

  2022cites this paper
• Identifying Active Compounds and Mechanisms of Citrus changshan-Huyou Y. B. Chang against URTIs-Associated Inflammation by Network Pharmacology in Combination with Molecular Docking

  2022cites this paper
• New Treatments for Asthma.

  2021cites this paper
• Metabolic Phenotypes in Asthmatic Adults: Relationship with Inflammatory and Clinical Phenotypes and Prognostic Implications

  2021cites this paper
• Tissue-Protective Effect of Erdosteine on Multiple-Organ Injuries Induced by Fine Particulate Matter

  2021cites this paper
• Association between particulate matter containing EPFRs and neutrophilic asthma through AhR and Th17

  2021cites this paper
• Anti-angiogenic Properties of Bevacizumab Improve Respiratory System Inflammation in Ovalbumin-Induced Rat Model of Asthma

  2021cites this paper
• Prevalence of Anemia in Pediatric Patients According to Asthma Control: Propensity Score Analysis

  2021cites this paper
• Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial.

  2021cites this paper
• Cytokines: From Clinical Significance to Quantification

  2021cites this paper
• Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma.

  2021cites this paper
• The 'cytokine storm': molecular mechanisms and therapeutic prospects.

  2021cites this paper
• Phenotypic Variations of Mild-to-Moderate Obstructive Pulmonary Diseases According to Airway Inflammation and Clinical Features

  2021cites this paper
• Severe Asthma in Children and Young People

  2021cites this paper
• Cellular mechanism underlying the facilitation of contractile response induced by tumor necrosis factor-α in mouse tracheal smooth muscle.

  2021cites this paper
• Novel Anti-Cytokine Strategies for Prevention and Treatment of Respiratory Allergic Diseases

  2021cites this paper
• An update on the diagnostic biomarkers for asthma

  2021cites this paper
• Role of IL-6 inhibitor in treatment of COVID-19-related cytokine release syndrome

  2021cites this paper
• Neutrophils in asthma: the good, the bad and the bacteria

  2021cites this paper
• Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation

  2021cites this paper
• Reciprocal Correlations of Inflammatory and Calcium Signaling in Asthma Pathogenesis.

  2021cites this paper
• Gestational hypertension and childhood atopy: a Millennium Cohort Study analysis

  2021cites this paper
• Title: The use of Ipratropium and Tiotropium as novel agents to reduce inflammation in in vitro macrophage models. Author: Ifteqar

  2021cites this paper
• Biologics in severe asthma.

  2021cites this paper
• Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway.

  2021cites this paper
• Which Therapy for Non-Type(T)2/T2-Low Asthma

  2021cites this paper
• ASP7266, a Novel Antibody against Human Thymic Stromal Lymphopoietin Receptor for the Treatment of Allergic Diseases

  2021cites this paper
• Asthma in the Precision Medicine Era: Biologics and Probiotics

  2021cites this paper
• The use of Ipratropium and Tiotropium as novel agents to reduce inflammation in in vitro macrophage models

  2021cites this paper
• An inflammatory stimulus sensitizes TRPA1 channel to increase cytokine release in human lung fibroblasts.

  2020cites this paper
• G Protein–Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action

  2020cites this paper