SCIENCE@home

Exploratory Analysis of Molecular Subtypes in Early-Stage Osteosarcoma: Identifying Resistance and Optimizing Therapy

Luka Bojic,Mina Perić,J. Karanović,Emilija Milošević,Natasa Kovacevic Grujicic,M. Milivojevic

Published 2025 in Cancers

ABSTRACT

Simple Summary Osteosarcoma is a malignant bone cancer with little progress in treatment and outcomes for the past 30 years. In this study, we attempted to subtype 102 tumor samples into distinct subtypes based on their gene expression and to explore specific expression profiles that would allow for precise treatment of each subtype. We identified three tumor subtypes with different functional characteristics. One identified subtype was shown to be more resistant to standard chemotherapy drugs and was linked to poorer patient outcomes. We also found that a natural compound, hesperidin, could increase the effectiveness of a typical chemotherapeutic doxorubicin in vitro. These findings could be used to guide more tailored treatment strategies in the early-stages of this disease, ultimately improving the quality of life of these young patients.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-100 of 114 references · Page 1 of 2

12
Next

CITED BY