Implications of omitting sentinel lymph node biopsy on adjuvant decision making for patients with small breast cancers

Selective omission of sentinel lymph node biopsy (SLNB) in patients with early breast cancer limits surgical morbidity. Adoption of this strategy relies on multidisciplinary consensus. Understanding how SLNB omission influences guideline‐based adjuvant treatment decisions, and the proportion of patients impacted, can help guide decision‐making.

• Publication year

  2025

• Venue

  Cancer

• Publication date

  2025-05-28

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/cncr.35910PMID 40433858PMCID 12117598
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Implications of omitting sentinel lymph node biopsy on adjuvant decision making for patients with small breast cancers

  2025cited by this paper
• Axillary Surgery in Breast Cancer - Primary Results of the INSEMA Trial.

  2024cited by this paper
• Ribociclib plus Endocrine Therapy in Early Breast Cancer.

  2024cited by this paper
• Impact of Sentinel Lymph Node Biopsy on Management of Older Women With Clinically Node-Negative, Early-Stage, ER+/HER2-, Invasive Breast Cancer: A Systematic Review and Meta-Analysis.

  2024cited by this paper
• Breast Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.

  2024cited by this paper
• Does Sentinel Lymph Node Biopsy Influence Subsequent Management Decisions in Women With Breast Cancer ≥ 70 Years Old?

  2024cited by this paper
• Real-World Implications of the SOUND Trial

  2024cited by this paper
• Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer.

  2023cited by this paper
• Partial Breast Irradiation for Patients With Early-Stage Invasive Breast Cancer or Ductal Carcinoma In Situ: An ASTRO Clinical Practice Guideline.

  2023cited by this paper
• Sentinel Lymph Node Biopsy vs No Axillary Surgery in Patients With Small Breast Cancer and Negative Results on Ultrasonography of Axillary Lymph Nodes

  2023cited by this paper
• NRG-BR007: A phase III trial evaluating de-escalation of breast radiation (DEBRA) following breast-conserving surgery (BCS) of stage 1, HR+, HER2-, RS ≤18 breast cancer.

  2023cited by this paper
• Omission of axillary sentinel lymph node biopsy in early invasive breast cancer

  2023cited by this paper
• Biomarkers for Adjuvant Endocrine and Chemotherapy in Early-Stage Breast Cancer: ASCO Guideline Update

  2022cited by this paper
• Abemaciclib plus endocrine therapy for hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer (monarchE): results from a preplanned interim analysis of a randomised, open-label, phase 3 trial.

  2022cited by this paper
• Patient-reported outcomes for the Intergroup Sentinel Mamma study (INSEMA): A randomised trial with persistent impact of axillary surgery on arm and breast symptoms in patients with early breast cancer

  2022cited by this paper
• Meta-Analysis of Trials of Partial Breast Irradiation.

  2022cited by this paper
• No axillary surgical treatment for lymph node-negative patients after ultra-sonography [NAUTILUS]: protocol of a prospective randomized clinical trial

  2022cited by this paper
• Management of the Axilla in Early-Stage Breast Cancer: Ontario Health (Cancer Care Ontario) and ASCO Guideline

  2021cited by this paper
• Outcomes with Partial Breast Irradiation vs. Whole Breast Irradiation: a Meta-Analysis

  2021cited by this paper
• Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer.

  2021cited by this paper
• Decreasing the Use of Sentinel Lymph Node Surgery in Women Older than 70 Years with Hormone Receptor-Positive Breast Cancer and the Impact on Adjuvant Radiation and Hormonal Therapy

  2021cited by this paper
• Risk factors for lymphedema after breast surgery: A prospective cohort study in the era of sentinel lymph node biopsy

  2021cited by this paper
• 21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer.

  2021cited by this paper
• De-escalating axillary surgery in early-stage breast cancer

  2021cited by this paper
• Nodal staging affects adjuvant treatment choices in elderly patients with clinically node-negative, estrogen receptor-positive breast cancer.

  2020cited by this paper
• Internal mammary and medial supraclavicular lymph node chain irradiation in stage I-III breast cancer (EORTC 22922/10925): 15-year results of a randomised, phase 3 trial.

  2020cited by this paper
• Is sentinel node biopsy necessary in the radiologically negative axilla in breast cancer?

  2019cited by this paper
• Long-term morbidity after a negative sentinel node in breast cancer patients.

  2019cited by this paper
• Associations Between Sentinel Lymph Node Biopsy and Complications for Patients with Ductal Carcinoma In Situ

  2018cited by this paper
• Adjuvant Chemotherapy Guided by a 21‐Gene Expression Assay in Breast Cancer

  2018cited by this paper
• Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013-08)

  2017cited by this paper
• Does lymph node status influence adjuvant therapy decision-making in women 70 years of age or older with clinically node negative hormone receptor positive breast cancer?

  2017cited by this paper
• Regional Nodal Irradiation in Early-Stage Breast Cancer.

  2015cited by this paper
• On weighting approaches for missing data

  2013cited by this paper
• Review of inverse probability weighting for dealing with missing data

  2013cited by this paper
• Defining menopausal status in epidemiologic studies: A comparison of multiple approaches and their effects on breast cancer rates.

  2010cited by this paper
• The National Cancer Data Base: A Powerful Initiative to Improve Cancer Care in the United States

  2008cited by this paper
• Surgical Complications Associated With Sentinel Lymph Node Biopsy: Results From a Prospective International Cooperative Group Trial

  2006cited by this paper
• Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer.

  2004cited by this paper
• The National Comprehensive Cancer Network

  1998cited by this paper
• Misclassification bias related to definition of menopausal status in case-control studies of breast cancer.

  1992cited by this paper
• Carcinoma in situ.

  1978cited by this paper

• Omission of Axillary Surgery in Early-Stage Breast Cancer: Implications for Multidisciplinary Decision-Making

  2026influential citation
• SENOPAUSE: Evaluation of an ASCO-Derived Clinical Proxy for Axillary Risk Stratification in a retrospective cohort

  2026cites this paper
• Implications of omitting sentinel lymph node biopsy on adjuvant decision making for patients with small breast cancers

  2025cites this paper
• Evaluating the role of sentinel lymph node biopsy in cT1–2N0M0 breast cancer: a SEER-based study

  2025cites this paper
• Omission of sentinel lymph node biopsy in early stage luminal breast cancer: impact on adjuvant CDK4/6 inhibitor recommendation and oncological outcomes

  2025influential citation