Central angiotensin II‐induced Alzheimer‐like tau phosphorylation in normal rat brains

No abstract is available for this paper.

• Publication year

  2012

• Venue

  FEBS Letters

• Publication date

  2012-10-19

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.febslet.2012.09.004PMID 22982863
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Amyloid deposition after cerebral hypoperfusion: evidenced on [(18)F]AV-45 positron emission tomography.

  2012cited by this paper
• Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tau.

  2012cited by this paper
• The Influence of Chronic Cerebral Hypoperfusion on Cognitive Function and Amyloid β Metabolism in APP Overexpressing Mice

  2011cited by this paper
• Primary Cerebral Blood Flow Deficiency and Alzheimer's Disease: Shadows and Lights

  2011cited by this paper
• Blockade of AT1 receptors protects the blood-brain barrier and improves cognition in Dahl salt-sensitive hypertensive rats.

  2011cited by this paper
• Cognitive enhancement following acute losartan in normotensive young adults

  2011cited by this paper
• Curcumin activates Wnt/β-catenin signaling pathway through inhibiting the activity of GSK-3β in APPswe transfected SY5Y cells.

  2011cited by this paper
• Amyloid‐β associated volume loss occurs only in the presence of phospho‐tau

  2011cited by this paper
• Perindopril, a centrally active angiotensin‐converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease

  2011cited by this paper
• GSK-3 alpha/beta kinases and amyloid production in vivo

  2011cited by this paper
• GSK-3α/β kinases and amyloid production in vivo

  2011cited by this paper
• Post-translational modifications of tau protein: implications for Alzheimer's disease.

  2011cited by this paper
• Systems neuroscience: The stress of dieting

  2011cited by this paper
• Central Angiotensin II Stimulation Promotes β Amyloid Production in Sprague Dawley Rats

  2011influential reference
• The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice

  2011cited by this paper
• The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

  2011cited by this paper
• Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

  2011influential reference
• Vascular risk factor detection and control may prevent Alzheimer's disease.

  2010cited by this paper
• The role of tau kinases in Alzheimer's disease.

  2010cited by this paper
• The Vascular Hypothesis of Alzheimer’s Disease: Bench to Bedside and Beyond

  2010cited by this paper
• Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partially Due to Peroxisome Proliferator-Activated Receptor-&ggr; Activation in Mice With Chronic Cerebral Hypoperfusion

  2010cited by this paper
• Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

  2010cited by this paper
• Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.

  2010cited by this paper
• Amyloid-β peptide alteration of tau exon-10 splicing via the GSK3β-SC35 pathway.

  2010cited by this paper
• The brain RAS and Alzheimer's disease.

  2010cited by this paper
• Angiotensins in Alzheimer's disease - friend or foe?

  2009cited by this paper
• Angiotensins and Alzheimer's disease: a bench to bedside overview

  2009cited by this paper
• Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide.

  2009cited by this paper
• The role of GSK3 in Alzheimer disease.

  2009cited by this paper
• The GSK3 hypothesis of Alzheimer's disease

  2008cited by this paper
• Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial.

  2008cited by this paper
• Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

  2007cited by this paper
• Brain and peripheral angiotensin II play a major role in stress

  2007cited by this paper
• Angiotensin II AT1 Receptor Blockade Abolishes Brain Microvascular Inflammation and Heat Shock Protein Responses in Hypertensive Rats

  2005cited by this paper
• Angiotensin II: An amplifier of cardiovascular risk

  2004influential reference
• Effect of intracerebroventricular angiotensin II on body weight and food intake in adult rats.

  2004cited by this paper
• Cardiology patient page. What is an angiotensin converting enzyme inhibitor?

  2003cited by this paper
• What Is an Angiotensin Converting Enzyme Inhibitor

  2003cited by this paper
• Protection Against Ischemia and Improvement of Cerebral Blood Flow in Genetically Hypertensive Rats by Chronic Pretreatment With an Angiotensin II AT1 Antagonist

  2002cited by this paper
• Angiotensin At1 Receptor Signalling Pathways In Neurons

  2002cited by this paper
• Cardiology patient page: warning signs of a heart attack.

  2001cited by this paper
• Pressure, platelets, and plaque: the central role of angiotensin II in cardiovascular pathology. Concluding comment.

  2001cited by this paper
• Pressure, platelets, and plaque: the central role of angiotensin II in cardiovascular pathology. Introduction.

  2001cited by this paper
• Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

  1992cited by this paper
• A Concluding Comment

  1988cited by this paper

• Neuroprotective effects of candesartan in 3-nitropropionic acid-induced Huntington’s disease: modulation of angiotensin and CREB/BDNF/PGC1-α signaling

  2025cites this paper
• Is The Renin-Angiotensin System A Friend or Foe in Neurological Diseases? Unveiling Its Role and Therapeutic Potential.

  2025cites this paper
• Mechanisms of angiotensin II to induce depression in diabetes

  2025cites this paper
• The GLP-1 Agonist Semaglutide Ameliorates Cognitive Regression in P301S Tauopathy Mice Model via Autophagy/ACE2/SIRT1/FOXO1-Mediated Microglia Polarization.

  2025cites this paper
• Dysregulation of the renin‐angiotensin system in vascular dementia

  2024cites this paper
• The Contribution of the Renin-Angiotensin System to Alzheimer's Disease.

  2024cites this paper
• High salt induces cognitive impairment via the interaction of the angiotensin II‐AT1 and prostaglandin E2‐EP1 systems

  2023cites this paper
• Altered Gene Expression Within the Renin–Angiotensin System in Normal Aging and Dementia

  2023cites this paper
• Diabetes-induced stimulation of the renin-angiotensin system in the rat brain cortex

  2023cites this paper
• QSAR modeling approaches to identify a novel ACE2 inhibitor that selectively bind with the C and N terminals of the ectodomain

  2023cites this paper
• Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System

  2023cites this paper
• Renin-angiotensin-system increases phosphorylated tau and Reactive Oxygen Species in human cortical neuron cell line

  2022cites this paper
• Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer’s disease pathology in mouse models of Alzheimer’s disease

  2022cites this paper
• Emerging Therapeutics Agents and Recent Advances in Drug Repurposing for Alzheimer's Disease.

  2022cites this paper
• Hypertension and cognitive dysfunction: a narrative review

  2022cites this paper
• Renin-Angiotensin System in Huntington′s Disease: Evidence from Animal Models and Human Patients

  2022cites this paper
• High salt induces cognitive impairment via the angiotensin II-AT1 and prostaglandin E2-EP1 systems

  2022cites this paper
• Losartan Mitigates Oxidative Stress in the Brains of Aged and Inflamed IL10 -/- Mice.

  2022cites this paper
• Targeting Brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: past, present and future.

  2022cites this paper
• AT1 Receptors: Their Actions from Hypertension to Cognitive Impairment

  2022cites this paper
• Glycogen Synthase Kinase-3 Inhibitors: Preclinical and Clinical Focus on CNS-A Decade Onward

  2022cites this paper
• Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: a systematic review.

  2021cites this paper
• Potential role of Drug Repositioning Strategy (DRS) for management of tauopathy.

  2021cites this paper
• Inhibition of Brain GTP Cyclohydrolase I Attenuates 3-Nitropropionic Acid-Induced Striatal Toxicity: Involvement of Mas Receptor/PI3k/Akt/CREB/ BDNF Axis

  2021cites this paper
• Higher Angiotensin II type 1 receptor (AT1R) levels and activity in the post-mortem brains of older persons with Alzheimer's disease.

  2021cites this paper
• Thioredoxin interacting protein, a key molecular switch between oxidative stress and sterile inflammation in cellular response

  2021cites this paper
• Losartan to slow the progression of mild-to-moderate Alzheimer’s disease through angiotensin targeting: the RADAR RCT

  2021cites this paper
• Renin-Angiotensin System Alterations in the Human Alzheimer’s Disease Brain

  2021cites this paper
• Angiotensin-(1-7) and Mas receptor in the brain

  2021cites this paper
• Research Progress on Mechanism of Neuroprotective Roles of Apelin-13 in Prevention and Treatment of Alzheimer’s Disease

  2021cites this paper
• The Role of Renin Angiotensin Aldosterone System in the Progression of Cognitive Dysfunction in Chronic Kidney Disease Patients with Alzheimer’s Disease

  2021cites this paper
• Functional analysis of brain derived neurotrophic factor (BDNF) in Huntington’s disease

  2021cites this paper
• ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

  2020cites this paper
• Cognitive impact of COVID-19: looking beyond the short term

  2020cites this paper
• Research Progress of Alzheimer’s Disease Therapeutic Drugs: Based on Renin-Angiotensin System Axis

  2020cites this paper
• Improvements of symptoms of Alzheimer`s disease by inhibition of the angiotensin system.

  2020cites this paper
• Brain Renin–Angiotensin System at the Intersect of Physical and Cognitive Frailty

  2020cites this paper
• Drug repositioning and repurposing for Alzheimer disease

  2020cites this paper
• Impact of COVID-19 on Alzheimer’s Disease Risk: Viewpoint for Research Action

  2020cites this paper
• The anti-Alzheimer effect of telmisartan in a hyperglycemic ovariectomized rat model; role of central angiotensin and estrogen receptors.

  2020cites this paper
• The Renin-Angiotensin System in Huntington’s Disease: Villain or Hero?

  2020cites this paper
• Neurovascular and Cognitive Dysfunction in Hypertension.

  2019cites this paper
• Drug interactions with dementia‐related pathophysiological pathways worsen or prevent dementia

  2019cites this paper
• Brain Vasculature and Cognition.

  2019cites this paper
• Chronic Angiotensin 1-7 Infusion Prevents Angiotensin-II-Induced Cognitive Dysfunction and Skeletal Muscle Injury in a Mouse Model of Alzheimer’s Disease

  2019cites this paper
• Angiotensin II triggers autophagy and apoptosis in PC12 cell line: An in vitro Alzheimer's disease model.

  2019cites this paper
• Challenges in the treatment of Alzheimer’s disease: recent progress and treatment strategies of pharmaceuticals targeting notable pathological factors

  2019cites this paper
• Apelin/APJ system: A novel promising target for neurodegenerative diseases

  2019cites this paper
• Cerebrospinal Fluid Changes in the Renin-Angiotensin System in Alzheimer’s Disease

  2019cites this paper
• Title: Cerebrospinal fluid changes in the renin-angiotensin system in Alzheimer’s disease

  2019influential citation
• Antihypertensive agents in Alzheimer’s disease: beyond vascular protection

  2019cites this paper
• Renin-angiotensin system and Alzheimer's disease pathophysiology: From the potential interactions to therapeutic perspectives.

  2019cites this paper
• Alzheimer’s dementia: pathogenesis and impact of cardiovascular risk factors on cognitive decline

  2019cites this paper
• Cerebral ischemia induced inflammatory response and altered glutaminergic function mediated through brain AT1 and not AT2 receptor.

  2018cites this paper
• Disparate Effects of Lithium and a GSK-3 Inhibitor on Neuronal Oscillatory Activity in Prefrontal Cortex and Hippocampus

  2018cites this paper
• Prevention and reversal of Alzheimer's disease: treatment protocol

  2018cites this paper
• Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway

  2018influential citation
• Effect of Resveratrol on Reactive Oxygen Species-Induced Cognitive Impairment in Rats with Angiotensin II-Ind uced Early Alzheimer’s Disease

  2018cites this paper
• The depressor axis of the renin-angiotensin system and brain disorders: a translational approach.

  2018cites this paper
• Apelin, a promising target for Alzheimer disease prevention and treatment.

  2018cites this paper
• Targeting Renin–Angiotensin System Against Alzheimer’s Disease

  2018cites this paper
• Angiotensin II degrades myeloid cell leukemia 1 in human umbilical vein endothelial cells

  2017cites this paper
• Losartan improves cerebrovascular function in a mouse model of Alzheimer's disease with combined overproduction of amyloid-β and transforming growth factor-β1

  2017cites this paper
• The Renin-Angiotensin System and the Neurodegenerative Diseases: A Brief Review.

  2017cites this paper
• Brain Angiotensin II Involvement in Chronic Mental Disorders.

  2017cites this paper
• Azilsartan ameliorates apoptosis of dopaminergic neurons and rescues characteristic parkinsonian behaviors in a rat model of Parkinson’s disease

  2017cites this paper
• Angiotensins and Huntington’s Disease: A Study on Immortalized Progenitor Striatal Cell Lines

  2017cites this paper
• Angiotensin-III is Increased in Alzheimer’s Disease in Association with Amyloid-β and Tau Pathology

  2017cites this paper
• Angiotensin-(1-7) administration attenuates Alzheimer's disease-like neuropathology in rats with streptozotocin-induced diabetes via Mas receptor activation.

  2017cites this paper
• Artemisia scoparia attenuates amyloid β accumulation and tau hyperphosphorylation in spontaneously hypertensive rats

  2017cites this paper
• Angiotensin II-triggered kinase signaling cascade in the central nervous system

  2016cites this paper
• Renin-angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical evidence.

  2016cites this paper
• Effects of Hypertension and Anti-Hypertensive Treatment on Amyloid-β (Aβ) Plaque Load and Aβ-Synthesizing and Aβ-Degrading Enzymes in Frontal Cortex

  2016cites this paper
• An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer’s disease

  2016cites this paper
• Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology

  2016cites this paper
• Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease.

  2016cites this paper
• Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic rats.

  2016cites this paper
• Older Adults Taking AT1-Receptor Blockers Exhibit Reduced Cerebral Amyloid Retention

  2016cites this paper
• Inhibition of glycogen synthase kinase 3 prevents synaptic long-term depression and facilitates cognition in C57BL/6J mice

  2016cites this paper
• Inhibition of ACE Retards Tau Hyperphosphorylation and Signs of Neuronal Degeneration in Aged Rats Subjected to Chronic Mild Stress

  2015cites this paper
• Differential effects of angiotensin II receptor blockers on A (cid:2) generation

  2015cites this paper
• Medical genetics-based drug repurposing for Alzheimer's disease.

  2015cites this paper
• “Boomerang Neuropathology” of Late-Onset Alzheimer’s Disease is Shrouded in Harmful “BDDS”: Breathing, Diet, Drinking, and Sleep During Aging

  2015cites this paper
• Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer’s Disease

  2015cites this paper
• Evidence of neurodegeneration in obstructive sleep apnea: Relationship between obstructive sleep apnea and cognitive dysfunction in the elderly

  2015cites this paper
• High Calorie Diet and the Human Brain

  2015cites this paper
• Contribution of Salt in Inducing Biochemical Changes in the Brain

  2015cites this paper
• Autoantibodies Toward the Angiotensin 2 Type 1 Receptor: A Novel Autoantibody in Alzheimer’s Disease

  2015cites this paper
• Degenerative Brain Diseases and White Matter Injury

  2014cites this paper
• Angiotensin (1-7) protects against stress-induced gastric lesions in rats.

  2014cites this paper
• Cognitive Enhancers (Nootropics). Part 1: Drugs interacting with Receptors. Update 2014

  2014cites this paper
• Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.

  2014influential citation
• Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes

  2014cites this paper
• The association of angiotensin-converting enzyme with biomarkers for Alzheimer’s disease

  2014cites this paper
• The Global Obesity Epidemic is Related to Stroke, Dementia and Alzheimer's Disease

  2014cites this paper
• Effects of Centrally Acting Angiotensin Converting Enzyme Inhibitors on Functional Decline in Patients with Alzheimer's Disease

  2014cites this paper
• Myelination, oligodendrocytes, and serious mental illness

  2014cites this paper
• Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins.

  2014cites this paper
• Differential effects of angiotensin II receptor blockers on Aβ generation.

  2014cites this paper
• The effects of centrally acting ACE inhibitors on the rate of cognitive and functional decline in dementia: a KDD approach

  2014cites this paper