Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface*

The S100 family of EF-hand calcium (Ca2+)-binding proteins is essential for a wide range of cellular functions. During infection, certain S100 proteins act as damage-associated molecular patterns (DAMPs) and interact with pattern recognition receptors to modulate inflammatory responses. In addition, these inflammatory S100 proteins have potent antimicrobial properties and are essential components of the immune response to invading pathogens. In this review, we focus on S100 proteins that exhibit antimicrobial properties through the process of metal limitation, termed nutritional immunity, and discuss several recent advances in our understanding of S100 protein-mediated metal sequestration at the site of infection.

• Publication year

  2015

• Venue

  Journal of Biological Chemistry

• Publication date

  2015-06-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1074/jbc.R115.645085PMID 26055713PMCID PMC4521021
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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