Stereoselective deprotonation installs an unusual Z-8,9 double bond during biosynthesis of the diterpene pheromone sobralene

A terpene synthase from the sandfly Lutzomyia longipalpis, catalyses stereoselective removal of the pro-S proton from C8 of geranylgeranyl diphosphate to generate the characteristic (Z)-8,9 double bond seen in the diterpene pheromone sobralene. Retention of deuterium in structurally related minor products demonstrates that they are not produced via sobralene, but are made directly by the enzyme.

• Publication year

  2025

• Venue

  Chemical Communications

• Publication date

  2025-07-07

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/d5cc03298aPMID 40641443PMCID 12246896
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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