The verticillenes. Pivotal intermediates in the biosynthesis of the taxanes and the phomactins.

Covering: up to May 2018The verticillene family of 6,12-membered ring-fused diterpenes are found in plants, liverworts, corals and insects. Carbocations derived from verticillene hydrocarbons are central intermediates in the biosynthesis of the taxane and the phomactin families of polycyclic natural products. This perspective delineates these unique biosynthetic interrelationships, which are reinforced by recent biomimetic synthesis investigations, alongside quantum chemical calculations and targeted engineering studies of the taxadiene synthase (TXS) cascade.

• Publication year

  2019

• Venue

  Natural product reports (Print)

• Publication date

  2019-01-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1039/c8np00034dPMID 29978865
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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