Studies on taxadiene synthase: interception of the cyclization cascade at the verticillene stage and rearrangement to phomactatriene

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Tetrahedron

• Publication date

  2007-07-02

• Fields of study

  Chemistry

• Identifiers
  DOI 10.1016/J.TET.2007.03.029
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Proposed mechanism for diterpene synthases in the formation of phomactatriene and taxadiene.

  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• Regioselectivity of taxoid-O-acetyltransferases: heterologous expression and characterization of a new taxadien-5alpha-ol-O-acetyltransferase.

  2004cited by this paper
• Biosynthesis of phomactins: common intermediate phomactatriene and taxadiene.

  2004cited by this paper
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  2004cited by this paper
• Total synthesis of (+/-)-phomactin G, a platelet activating factor antagonist from the marine fungus Phoma sp.

  2004cited by this paper
• Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis.

  2004cited by this paper
• Phomactin H, a novel diterpene from an unidentified marine-derived fungus

  2004cited by this paper
• Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7 beta-hydroxylase.

  2004cited by this paper
• A total synthesis of phomactin A.

  2003cited by this paper
• Total synthesis of (+)-phomactin a using a B-alkyl Suzuki macrocyclization.

  2003cited by this paper
• MAXIMIZING RETURNS: A driving force in getting Taxol to market quickly, NIH is being asked to evaluate the way it deals with the private-sector partnerships

  2003cited by this paper
• The final acylation step in Taxol biosynthesis: Cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus

  2002cited by this paper
• A total synthesis of (+/-)-phomactin A.

  2002cited by this paper
• Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis

  2002cited by this paper
• Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells.

  2001cited by this paper
• Taxol biosynthesis: Taxane 13α-hydroxylase is a cytochrome P450-dependent monooxygenase

  2001cited by this paper
• Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast.

  2001cited by this paper
• Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol.

  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Comprehensive natural products chemistry

  1999cited by this paper
• Asymmetric Total Synthesis of Taxol\R

  1999cited by this paper
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  1999cited by this paper
• Enantioselective Total Synthesis of (−)-Taxol

  1998cited by this paper
• Overproduction, in Escherichia coli, of soluble taxadiene synthase, a key enzyme in the Taxol biosynthetic pathway.

  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• A cDNA Clone for Taxadiene Synthase, the Diterpene Cyclase That Catalyzes the Committed Step of Taxol Biosynthesis

  1996cited by this paper
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  1995cited by this paper
• Purification and characterization of taxa-4(5),11(12)-diene synthase from Pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis.

  1995cited by this paper
• Cyclization of Geranylgeranyl Diphosphate to Taxa-4 (5), 11 (12) -diene Is the Committed Step of Taxol Biosynthesis in Pacific Yew (*)

  1995cited by this paper
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  1995cited by this paper
• Taxol®: science and applications.

  1995cited by this paper
• The Conquest of Taxol

  1995cited by this paper
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  1994cited by this paper
• First total synthesis of taxol. 1. Functionalization of the B ring

  1994cited by this paper
• Total synthesis of taxol

  1994cited by this paper
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  1994cited by this paper
• The taxane diterpenoids.

  1994cited by this paper
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  1993cited by this paper
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  1992cited by this paper
• Phomactin A; a novel PAF antagonist from a marine fungus Phoma sp

  1991cited by this paper
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• About the mechanism of sterol biosynthesis

  1987cited by this paper
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  1986cited by this paper
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  1985cited by this paper
• [15] Synthesis of allylic and homoallylic isoprenoid pyrophosphates

  1985cited by this paper
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  1978cited by this paper
• Enzymic cyclization of trans,trans,trans-18,19-dihydrosqualene 2,3-oxide.

  1967cited by this paper

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