Regulatory T cells and transplantation tolerance.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Immunotherapy

• Publication date

  2013-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2217/imt.13.69PMID 23829623
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans

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• Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

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• Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB

  2013cited by this paper
• This information is current as Induction of Therapeutic Tissue Tolerance Foxp 3 Expression Is Required for the Waldmann

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• Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth

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• Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict.

  2012cited by this paper
• Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

  2012cited by this paper
• Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency.

  2012cited by this paper
• Histone Deacetylases 6 and 9 and Sirtuin-1 Control Foxp3+ Regulatory T Cell Function Through Shared and Isoform-Specific Mechanisms

  2012cited by this paper
• T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.

  2012cited by this paper
• Immune tolerance: Are regulatory T cell subsets needed to explain suppression of autoimmunity?

  2012cited by this paper
• Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

  2012cited by this paper
• Mixed chimerism through donor bone marrow transplantation: a tolerogenic cell therapy for application in organ transplantation

  2012cited by this paper
• Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity

  2012cited by this paper
• Novel Foxo1-dependent transcriptional programs control Treg cell function

  2012cited by this paper
• Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification.

  2012cited by this paper
• Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.

  2012cited by this paper
• Some observations on prope tolerance

  2011cited by this paper
• Spectrum of cancer risk among US solid organ transplant recipients.

  2011cited by this paper
• Phenotypical and functional specialization of FOXP3+ regulatory T cells

  2011cited by this paper
• Interleukin-2 and regulatory T cells in graft-versus-host disease.

  2011cited by this paper
• Regulatory T cell plasticity: beyond the controversies.

  2011cited by this paper
• Single-Cell Analysis of the Human T Regulatory Population Uncovers Functional Heterogeneity and Instability within FOXP3+ Cells

  2011cited by this paper
• A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity.

  2011cited by this paper
• Tissue-based class control: the other side of tolerance

  2011cited by this paper
• Follicular regulatory T ( Tfr ) cells with dual Foxp 3 and Bcl 6 expression suppress germinal center reactions

  2011cited by this paper
• Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance

  2011cited by this paper
• IL-2 Controls the Stability of Foxp3 Expression in TGF-β–Induced Foxp3+ T Cells In Vivo

  2011cited by this paper
• TGF-β in transplantation tolerance.

  2011cited by this paper
• IL-35-mediated induction of a potent regulatory T cell population

  2010cited by this paper
• Enhancement of antigen-specific Treg vaccination in vivo

  2010cited by this paper
• Rejection of the kidney allograft.

  2010cited by this paper
• In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response

  2010cited by this paper
• Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

  2010cited by this paper
• Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

  2010cited by this paper
• mTOR signalling and metabolic regulation of T cell differentiation.

  2010cited by this paper
• Stability of the Regulatory T Cell Lineage in Vivo

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• Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation1

  2009cited by this paper
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  2009cited by this paper
• T-bet controls regulatory T cell homeostasis and function during type-1 inflammation

  2009cited by this paper
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• TCR Repertoire and Foxp3 Expression Define Functionally Distinct Subsets of CD4+ Regulatory T Cells1

  2009cited by this paper
• In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

  2009cited by this paper
• Regulatory lymphocytes and intestinal inflammation.

  2009cited by this paper
• Regulatory T cells: how do they suppress immune responses?

  2009cited by this paper
• Neuropilin‐1 is not a marker of human Foxp3+ Treg

  2009cited by this paper
• Calcineurin inhibitor nephrotoxicity.

  2009cited by this paper
• Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions

  2009cited by this paper
• Heterogeneity of natural Foxp3+ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

  2009cited by this paper
• Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

  2009cited by this paper
• Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

  2009cited by this paper
• Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue.

  2009cited by this paper
• Infectious tolerance via the consumption of essential amino acids and mTOR signaling

  2009cited by this paper
• Tolerance and chimerism after renal and hematopoietic-cell transplantation.

  2008cited by this paper
• Regulatory T cells and immune tolerance.

  2008cited by this paper
• Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

  2008cited by this paper
• A two-step process for thymic regulatory T cell development.

  2008cited by this paper
• HLA-mismatched renal transplantation without maintenance immunosuppression.

  2008cited by this paper
• DNA methylation controls Foxp3 gene expression

  2008cited by this paper
• How regulatory T cells work

  2008cited by this paper
• Interferon-&ggr; Conditioning Ex Vivo Generates CD25+CD62L+Foxp3+ Regulatory T Cells That Prevent Allograft Rejection: Potential Avenues for Cellular Therapy

  2008cited by this paper
• Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression

  2008cited by this paper
• Rapamycin-Conditioned Dendritic Cells Are Poor Stimulators of Allogeneic CD4+ T Cells, but Enrich for Antigen-Specific Foxp3+ T Regulatory Cells and Promote Organ Transplant Tolerance1

  2007cited by this paper
• Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

  2007cited by this paper
• Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

  2007cited by this paper
• Infection in solid-organ transplant recipients.

  2007cited by this paper
• Regulatory T cells and infection: a dangerous necessity

  2007cited by this paper
• Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

  2007cited by this paper
• Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

  2007cited by this paper
• A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity

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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Accelerated Memory Cell Homeostasis during T Cell Depletion and Approaches to Overcome It

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• CAMPATH: from concept to clinic

  2005cited by this paper
• Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor

  2005cited by this paper
• Inducing and expanding regulatory T cell populations by foreign antigen

  2005cited by this paper
• Induction of foxP3+ Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants1

  2004cited by this paper
• Homeostatic proliferation is a barrier to transplantation tolerance

  2004cited by this paper
• Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells.

  2004cited by this paper
• Immunosuppressive drugs for kidney transplantation.

  2004cited by this paper
• Kidney Transplantation Under a Tolerogenic Regimen of Recipient Pretreatment and Low-Dose Postoperative Immunosuppression With Subsequent Weaning

  2003cited by this paper
• An essential role for Scurfin in CD4+CD25+ T regulatory cells

  2003cited by this paper
• Supporting Online Material

  2003cited by this paper
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  2003cited by this paper
• Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

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• Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

  2001cited by this paper
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  1996cited by this paper
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  1994cited by this paper
• "Infectious" transplantation tolerance

  1993cited by this paper
• Reprogramming the Immune System for Peripheral Tolerance with CD4 and CD8 Monoclonal Antibodies

  1992cited by this paper
• Induction of classical transplantation tolerance in the adult

  1989cited by this paper
• Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance

  1986cited by this paper
• Quantitative studies on tissue transplantation immunity. II. The origin, strength and duration of actively and adoptively acquired immunity

  1954cited by this paper

• The immunosuppression effects of deforolimus (ridaforolimus, AP23573) on allograft organ transplantation

  2023cites this paper
• Increased Suppressor Activity of Ex Vivo Transformed Regulatory T Cells in Comparison with Unstimulated Cells of the Same Donor

  2022cites this paper
• Linking erythropoietin to Treg-dependent allograft survival through myeloid cells

  2022cites this paper
• [Increased suppressor activity of transformed ex vivo regulatory T-cells in comparison with unstimulated cells of the same donor].

  2022cites this paper
• The applications of DNA methylation as a biomarker in kidney transplantation: a systematic review

  2022cites this paper
• Autoimmunity, regulatory T cells, and pregnancy: Maintaining the balance

  2021cites this paper
• Effect of FOXP3 gene variants on the immune-active HBV and inactive HBV phases

  2021cites this paper
• Blockade of OX40/OX40L pathway combined with ethylene-carbodiimide-fixed donor splenocytes induces donor-specific allograft tolerance in presensitized recipients.

  2020cites this paper
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• Glycogen synthase kinase 3β inhibition promotes human iTreg differentiation and suppressive function

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• Anti-OX40L monoclonal antibody prolongs secondary heart allograft survival based on CD40/CD40L and LFA-1/ICAM-1 blockade.

  2015cites this paper
• CD28 signals the differential control of regulatory T cells and effector T cells

  2014cites this paper
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