Naringenin/naringin therapeutic effects and the role of intestinal microflora in them.

The intestinal microflora represents a collection of microorganisms residing in the gastrointestinal tract. Alterations in the composition of the intestinal microflora may disrupt the stability of the intestinal ecosystem and adversely affect the health of the host. Previously, several studies have demonstrated that dietary interventions have the potential to reshape the intestinal microflora and thereby promote host health. Naringenin and naringin are natural dietary flavonoids, which possess a wide range of biological activities, including anti-inflammatory, antioxidant, anticancer, hypoglycemic activities, and the ability to improve lipid metabolism. Studies indicate that the intestinal microflora can metabolize naringenin and naringin into several phenolic and aromatic ring-fission catabolites, and consequently exerting unique physiological activities. In turn, naringenin and naringin were found to impact on the composition and metabolites of intestinal microflora. This review will summarize existing studies on the bidirectional interactions between naringenin/naringin and intestinal microflora, and explore how these interactions contribute to the pharmacological effects of naringenin/naringin and discuss their potential to improve host health as natural agents.

• Publication year

  2025

• Venue

  Pharmacological Research

• Publication date

  2025-07-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.phrs.2025.107871PMID 40701346
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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