Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21Waf1/Cip1

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Oncogene

• Publication date

  2010-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2009.497PMID 20101223
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008influential reference
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  2007cited by this paper
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  2006cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

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  1989cited by this paper

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