Ethanol influences on Bax translocation, mitochondrial membrane potential, and reactive oxygen species generation are modulated by vitamin E and brain-derived neurotrophic factor.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Alcoholism: Clinical and Experimental Research

• Publication date

  2011-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1530-0277.2011.01445.xPMID 21332533PMCID PMC3097312
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Brain‐Derived Neurotrophic Factor Enhances Bcl‐xL Expression Through Protein Kinase Casein Kinase 2‐Activated and Nuclear Factor Kappa B‐Mediated Pathway in Rat Hippocampus

  2011cited by this paper
• BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons.

  2009cited by this paper
• Protective effect of vitamin E against ethanol-induced hyperhomocysteinemia, DNA damage, and atrophy in the developing male rat brain.

  2009cited by this paper
• BAX Activation is Initiated at a Novel Interaction Site

  2008cited by this paper
• Age- and area-dependent distinct effects of ethanol on Bax and Bcl-2 expression in prenatal rat brain.

  2008influential reference
• Vitamin E prevents hypobaric hypoxia-induced mitochondrial dysfunction in skeletal muscle.

  2007cited by this paper
• Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death

  2007cited by this paper
• Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase Activate Bax to Induce Mitochondrial Cytochrome c Release and Apoptosis in Response to Malonate

  2007cited by this paper
• Effect of bax deletion on ethanol sensitivity in the neonatal rat cerebellum.

  2006cited by this paper
• Secretion of brain‐derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling

  2006cited by this paper
• Vitamin E does not protect against neonatal ethanol-induced cerebellar damage or deficits in eyeblink classical conditioning in rats.

  2005cited by this paper
• Attenuation of brain derived neurotrophic factor (BDNF) by ethanol and cytoprotective effect of exogenous BDNF against ethanol damage in neuronal cells

  2005cited by this paper
• Molecular Regulation of Acute Ethanol-Induced Neuron Apoptosis

  2005influential reference
• Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems.

  2005cited by this paper
• Synergistic effects of hydrogen peroxide and ethanol on cell viability loss in PC12 cells by increase in mitochondrial permeability transition.

  2005cited by this paper
• Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways

  2005cited by this paper
• Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H2O2-induced neuronal death.

  2005cited by this paper
• Functional mechanisms of apoptosis‐related proteins in neonatal rat cerebellum are differentially influenced by ethanol at postnatal days 4 and 7

  2005cited by this paper
• Programmed cell death via mitochondria: Different modes of dying

  2005cited by this paper
• Brain‐derived neurotrophic factor prevents changes in Bcl‐2 family members and caspase‐3 activation induced by excitotoxicity in the striatum

  2005influential reference
• Bcl-2 in endothelial cells is increased by vitamin E and alpha-lipoic acid supplementation but not exercise training.

  2005cited by this paper
• Ethanol inhibits brain-derived neurotrophic factor-mediated intracellular signaling and activator protein-1 activation in cerebellar granule neurons.

  2004cited by this paper
• Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat.

  2004cited by this paper
• Pycnogenol and vitamin E inhibit ethanol-induced apoptosis in rat cerebellar granule cells.

  2004cited by this paper
• Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice.

  2004cited by this paper
• Mitochondrial mechanisms of neural cell apoptosis

  2004cited by this paper
• JNK promotes Bax translocation to mitochondria through phosphorylation of 14‐3‐3 proteins

  2004cited by this paper
• Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure.

  2004cited by this paper
• Vitamin E amelioration of ethanol neurotoxicity involves modulation of apoptotis-related protein levels in neonatal rat cerebellar granule cells.

  2004cited by this paper
• Ethanol-induced reduction of neurotrophin secretion in neonatal rat cerebellar granule cells is mitigated by vitamin E.

  2004cited by this paper
• Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9.

  2004cited by this paper
• Oxidative stress and antioxidant defenses in ethanol-induced cell injury.

  2004cited by this paper
• Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes.

  2004cited by this paper
• Protective mechanisms of pycnogenol in ethanol-insulted cerebellar granule cells.

  2004cited by this paper
• Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure.

  2004cited by this paper
• Vitamin E blocks early events induced by 1‐methyl‐4‐phenylpyridinium (MPP+) in cerebellar granule cells

  2003cited by this paper
• The role of alpha-tocopherol in preventing disease: from epidemiology to molecular events.

  2003cited by this paper
• Ethanol‐induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons

  2003cited by this paper
• Effects of ethanol on neurotrophic factors, apoptosis-related proteins, endogenous antioxidants, and reactive oxygen species in neonatal striatum: relationship to periods of vulnerability.

  2003cited by this paper
• Neuroprotective effects of α-tocopherol on oxidative stress in rat striatal cultures

  2003cited by this paper
• The role of α-tocopherol in preventing disease: from epidemiology to molecular events

  2003cited by this paper
• Ethanol effects on neonatal rat cortex: comparative analyses of neurotrophic factors, apoptosis-related proteins, and oxidative processes during vulnerable and resistant periods.

  2003cited by this paper
• FGF-2, NGF and IGF-1, but not BDNF, utilize a nitric oxide pathway to signal neurotrophic and neuroprotective effects against alcohol toxicity in cerebellar granule cell cultures.

  2003cited by this paper
• The mitochondrial membrane potential (Δψm) in apoptosis; an update

  2003cited by this paper
• Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain

  2003cited by this paper
• Neuroprotective effects of alpha-tocopherol on oxidative stress in rat striatal cultures.

  2003cited by this paper
• The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update.

  2003cited by this paper
• The role of neurotrophic factors, apoptosis-related proteins, and endogenous antioxidants in the differential temporal vulnerability of neonatal cerebellum to ethanol.

  2003cited by this paper
• Influence of ethanol on neonatal cerebellum of BDNF gene-deleted animals: analyses of effects on Purkinje cells, apoptosis-related proteins, and endogenous antioxidants.

  2002cited by this paper
• Ethanol-mediated generation of reactive oxygen species in developing rat cerebellum.

  2002cited by this paper
• Changes of bcl-2 and bax mRNA expressions in the ethanol-treated mouse brain.

  2002cited by this paper
• Bax and Bak Independently Promote Cytochrome cRelease from Mitochondria*

  2002cited by this paper
• Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons

  2002cited by this paper
• Effects of Brain‐Derived Neurotrophic Factor (BDNF) on Compression‐Induced Spinal Cord Injury: BDNF Attenuates Down‐Regulation of Superoxide Dismutase Expression and Promotes Up‐Regulation of Myelin Basic Protein Expression

  2002cited by this paper
• Ethanol-induced caspase-3 activation in the in vivo developing mouse brain.

  2002cited by this paper
• Mechanisms Underlying the Protective Potential of α-Tocopherol (Vitamin E) against Haloperidol-associated Neurotoxicity

  2002cited by this paper
• Alpha7 nicotinic receptor activation inhibits ethanol‐induced mitochondrial dysfunction, cytochrome c release and neurotoxicity in primary rat hippocampal neuronal cultures

  2002cited by this paper
• Vitamin E: protective role of a Janus molecule

  2001cited by this paper
• Acute ethanol administration oxidatively damages and depletes mitochondrial dna in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants.

  2001cited by this paper
• Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets.

  2001cited by this paper
• Glutamate signaling and the fetal alcohol syndrome.

  2001influential reference
• In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4-hydroxynonenal.

  2001cited by this paper
• Overexpression of NGF ameliorates ethanol neurotoxicity in the developing cerebellum.

  2000cited by this paper
• Amelioration of ethanol-induced neurotoxicity in the neonatal rat central nervous system by antioxidant therapy.

  2000cited by this paper
• Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

  2000cited by this paper
• Modulation by alpha- and gamma-tocopherol and oxidized low-density lipoprotein of apoptotic signaling in human coronary smooth muscle cells.

  2000cited by this paper
• Neurotrophic factor protection against ethanol toxicity in rat cerebellar granule cell cultures requires phosphatidylinositol 3-kinase activation.

  2000cited by this paper
• Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome.

  2000cited by this paper
• Intravenous Brain-Derived Neurotrophic Factor Reduces Infarct Size and Counterregulates Bax and Bcl-2 Expression After Temporary Focal Cerebral Ischemia

  2000cited by this paper
• N‐terminal cleavage of Bax by calpain generates a potent proapoptotic 18‐kDa fragment that promotes Bcl‐2‐independent cytochrome C release and apoptotic cell death

  2000cited by this paper
• Modulation by α- and γ-tocopherol and oxidized low-density lipoprotein of apoptotic signaling in human coronary smooth muscle cells

  2000cited by this paper
• The effect of ethanol on lipid peroxidation and glutathione level in the brain stem of rat.

  1999cited by this paper
• Gangliosides Attenuate Ethanol-Induced Apoptosis in Rat Cerebellar Granule Neurons

  1999cited by this paper
• Ethanol-induced alterations in neurotrophin expression in developing cerebellum: relationship to periods of temporal susceptibility.

  1999cited by this paper
• Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade.

  1999cited by this paper
• More than one way to die: apoptosis, necrosis and reactive oxygen damage

  1999cited by this paper
• Vitamin E and beta-carotene protect against ethanol combined with ischemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome.

  1999cited by this paper
• Brain-Derived Neurotrophic Factor Mediates the Anti-Apoptotic Effect of NMDA in Cerebellar Granule Neurons: Signal Transduction Cascades and Site of Ethanol Action

  1999influential reference
• Brain-derived and glial cell line-derived neurotrophic factors protect a catecholaminergic cell line from dopamine-induced cell death.

  1999influential reference
• Dose response of ethanol ingestion on antioxidant defense system in rat brain subcellular fractions.

  1999cited by this paper
• BDNF and NGF Afford in vitro Neuroprotection against Ethanol Combined with Acute Ischemia and Chronic Hypoglycemia

  1999cited by this paper
• Reduction of ischemic damage in NGF-transgenic mice: correlation with enhancement of antioxidant enzyme activities.

  1999cited by this paper
• Ethanol decreases Glial-Derived Neurotrophic Factor (GDNF) protein release but not mRNA expression and increases GDNF-stimulated Shc phosphorylation in the developing cerebellum.

  1999cited by this paper
• Neonatal ethanol exposure alters bcl-2 family mRNA levels in the rat cerebellar vermis.

  1999cited by this paper
• BCL-2 family members and the mitochondria in apoptosis.

  1999cited by this paper
• Nerve Growth Factor Determines Survival and Death of PC12 Cells by Regulation of the bcl‐x, bax, and caspase‐3 Genes

  1999cited by this paper
• The antioxidants vitamin E and beta-carotene protect against ethanol-induced neurotoxicity in embryonic rat hippocampal cultures.

  1999cited by this paper
• Brain-derived neurotropic factor prevents superoxide anion-induced death of PC12h cells stably expressing TrkB receptor via modulation of reactive oxygen species.

  1999cited by this paper
• Brain-derived neurotrophic factor prevents superoxide anion-induced death of PC12h cells stably expressing TrkB receptor via modulation of reactive oxygen species

  1999cited by this paper
• Vitamin E and β-carotene protect against ethanol combined with ischemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome

  1999cited by this paper
• Brain-derived neurotrophic factor (BDNF) protects cultured rat cerebellar granule neurons against glucose deprivation-induced apoptosis

  1998cited by this paper
• P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors

  1998cited by this paper
• Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis.

  1998cited by this paper
• Neurotrophins Rescue Cerebellar Granule Neurons from Oxidative Stress‐Mediated Apoptotic Death: Selective Involvement of Phosphatidylinositol 3‐Kinase and the Mitogen‐Activated Protein Kinase Pathway

  1998cited by this paper
• Neurotrophins Protect Cultured Cerebellar Granule Neurons against the Early Phase of Cell Death by a TwoComponent Mechanism

  1997cited by this paper
• Cooperative Interception of Neuronal Apoptosis by BCL‐2 and BAG‐1 Expression: Prevention of Caspase Activation and Reduced Production of Reactive Oxygen Species

  1997cited by this paper
• Autocrine regulation of apoptosis and bcl-2 expression by nerve growth factor in early differentiating cerebellar granule neurons involves low affinity neurotrophin receptor.

  1997cited by this paper
• Ethanol Promotes Apoptosis in Cerebellar Granule Cells by Inhibiting the Trophic Effect of NMDA

  1997cited by this paper
• BDNF protection of auditory neurons from cisplatin involves changes in intracellular levels of both reactive oxygen species and glutathione.

  1997influential reference
• Nerve growth factor and basic fibroblast growth factor protect rat cerebellar granule cells in culture against ethanol-induced cell death.

  1997cited by this paper

• Assessment of ethanol exposure from hand sanitizer use and potential for developmental toxicity in nursing infants

  2022cites this paper
• The role of growth factors in human sperm parameters: A review of in vitro studies

  2022cites this paper
• Histopathologic evaluation of the inflammatory factors and stromal cells in the endometriosis lesions: A case-control study

  2022cites this paper
• Artabotrys odoratissimus Bark Extract Restores Ethanol Induced Redox Imbalance and Toxicity in Hepatocytes and In Vivo Model

  2022cites this paper
• Pilot Study on Analysis of Electroencephalography Signals from Children with FASD with the Implementation of Naive Bayesian Classifiers

  2021cites this paper
• Inhibition of the electron transport chain in propofol induced neurotoxicity in zebrafish embryos.

  2020cites this paper
• Caffeine Potentiates Ethanol-Induced Neurotoxicity Through mTOR/p70S6K/4E-BP1 Inhibition in SH-SY5Y Cells

  2020cites this paper
• Propolis ameliorates cerebral injury in focal cerebral ischemia/reperfusion (I/R) rat model via upregulation of TGF-β1

  2019cites this paper
• Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus.

  2019cites this paper
• Diterpene pekinenal from euphorbia pekinensis radix induced IEC-6 cells apoptosis mediated by mitochondria and death receptors.

  2019cites this paper
• The Effects of Thymoquinone Against Morphine-induced Damages on Male Mice Liver

  2018cites this paper
• Taurine prevents ethanol-induced apoptosis mediated by mitochondrial or death receptor pathways in liver cells

  2018cites this paper
• Effect of Thymoquinone on Reproductive Parameter in Morphine-treated Male Mice

  2018cites this paper
• Retinal Wnt signaling defect in a zebrafish fetal alcohol spectrum disorder model

  2018cites this paper
• Betulinic acid induces apoptosis and inhibits metastasis of human renal carcinoma cells in vitro and in vivo

  2018cites this paper
• Alcohol and thiamine deficiency trigger differential mitochondrial transition pore opening mediating cellular death

  2017cites this paper
• ProBDNF/p75NTR/sortilin pathway is activated in peripheral blood of patients with alcohol dependence

  2017cites this paper
• Effect of brain‐derived neurotrophic factor on sperm function, oxidative stress and membrane integrity in human

  2017cites this paper
• The Neuroprotective Effects of Carvacrol on Ethanol-Induced Hippocampal Neurons Impairment via the Antioxidative and Antiapoptotic Pathways

  2017cites this paper
• Turmeric Extract Rescues Ethanol-Induced Developmental Defect in the Zebrafish Model for Fetal Alcohol Spectrum Disorder (FASD).

  2017cites this paper
• Ethanol Consumption Affects Neuronal Function: Role of the Mitochondria

  2017cites this paper
• Role of Autophagy Activation in Alleviating Alcohol Neurotoxicity

  2017cites this paper
• Characterization of ethanol-induced effects on zebrafish retinal development: Mechanistic perspective and therapeutic strategies

  2016cites this paper
• Alpha-Tocopherol Counteracts the Effect of Ethanol on Cortical Spreading Depression in Rats of Various Ages, With and Without Ethanol Abstinence.

  2016cites this paper
• Supplementation of freezing and thawing media with brain-derived neurotrophic factor protects human sperm from freeze-thaw-induced damage.

  2016cites this paper
• ANTIOXIDANT AND ANTIAPOPTIC EFFECTS OF COMBINED SIDR HONEY AND NIGELLA SATIVA OIL AGAINST PARACETAMOL-INDUCED HEPATO-NEPHROTOXICITY IN RATS

  2016cites this paper
• Prevention of inflammatory cellular responses by ethanol and hemin interplay between inflammasomes and processes inhibiting inflammation

  2015cites this paper
• Zebrafish retinal defects induced by ethanol exposure are rescued by retinoic acid and folic acid supplement.

  2015cites this paper
• Apoptotic cell death and temporal expression of apoptotic proteins Bcl-2 and Bax in the hippocampus, following binge ethanol in the neonatal rat model.

  2015cites this paper
• Differential effects of ethanol on bid, tBid, and Bax:tBid interactions in postnatal day 4 and postnatal day 7 rat cerebellum.

  2015influential citation
• Could Thymoquinone Protect The Liver Against Indomethacin Toxicity ?

  2014cites this paper
• Autophagy and ethanol neurotoxicity

  2014cites this paper
• PDLLA/PRGD/β-TCP conduits build the neurotrophin-rich microenvironment suppressing the oxidative stress and promoting the sciatic nerve regeneration.

  2014cites this paper
• The effects of bioactive compounds from plant foods on mitochondrial function: a focus on apoptotic mechanisms.

  2014cites this paper
• Neuroprotection via maintenance or increase of antioxidants and neurotrophic factors in ischemic gerbil hippocampus treated with tanshinone I.

  2014cites this paper
• Ethanol influences on bax associations with mitochondrial membrane proteins in neonatal rat cerebellum

  2013cites this paper
• Fetal Alcohol Spectrum Disorder (FASD) Associated Neural Defects: Complex Mechanisms and Potential Therapeutic Targets

  2013influential citation
• Involvement of Sphingolipids in Ethanol Neurotoxicity in the Developing Brain

  2013cites this paper
• Postnatal exposure to trichloroethylene alters glutathione redox homeostasis, methylation potential, and neurotrophin expression in the mouse hippocampus.

  2012cites this paper
• Differential effects of ethanol on c-jun N-terminal kinase, 14-3-3 proteins, and Bax in postnatal day 4 and postnatal day 7 rat cerebellum.

  2012cites this paper
• Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons

  2012cites this paper
• Mechanistic Insights into Neurotoxicity Induced by Anesthetics in the Developing Brain

  2012cites this paper
• Association of Glutathione Level and Cytotoxicity of Gold Nanoparticles in Lung Cancer Cells

  2011cites this paper
• The role of reactive oxygen species in WP 631-induced death of human ovarian cancer cells: a comparison with the effect of doxorubicin.

  2011cites this paper
• Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists.

  2011cites this paper