Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities

The Annexin (ANXA) protein family, which is ubiquitously expressed across various tissues, encodes versatile calcium (Ca2+)- and phospholipid-binding proteins that play crucial roles in modulating inflammation and cell signaling pathways. This family significantly influences several essential cellular processes, including cell adhesion, proliferation, migration, differentiation, and apoptosis. ANXAs are integral to physiological regulation and the pathological states associated with liver diseases. Dysregulated expression of ANXAs has been linked to a spectrum of liver conditions, including metabolic dysfunction, hepatocyte damage, fibrosis, and tumor formation. In this review, we outline recent advancements in understanding the roles of ANXAs in liver diseases. Further investigation into the roles of ANXAs in the liver could enhance our understanding of the mechanisms underlying liver diseases and may identify biomarkers and therapeutic targets for liver diseases in the future.

• Publication year

  2025

• Venue

  Frontiers in Pharmacology

• Publication date

  2025-07-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.3389/fphar.2025.1569927PMID 40717977PMCID 12289494
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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