Directing stem cell fate on hydrogel substrates by controlling cell geometry, matrix mechanics and adhesion ligand composition.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Biomaterials

• Publication date

  2013-11-01

• Fields of study

  Biology, Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1016/j.biomaterials.2013.07.074PMID 23932245
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

  2013cited by this paper
• Physical cues of biomaterials guide stem cell differentiation fate.

  2013cited by this paper
• The effect of mesenchymal stem cell shape on the maintenance of multipotency.

  2013cited by this paper
• Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells.

  2012cited by this paper
• Tailored Integrin–Extracellular Matrix Interactions to Direct Human Mesenchymal Stem Cell Differentiation

  2012cited by this paper
• Directing stem cell fate by controlling the affinity and density of ligand-receptor interactions at the biomaterials interface.

  2012cited by this paper
• Extracellular-matrix tethering regulates stem-cell fate.

  2012cited by this paper
• Chemically well-defined self-assembled monolayers for cell culture: toward mimicking the natural ECM.

  2011cited by this paper
• Josephson supercurrent through a topological insulator surface state.

  2011cited by this paper
• Mechanisms of mechanical signaling in development and disease

  2011cited by this paper
• The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β.

  2011cited by this paper
• Effect of cell anisotropy on differentiation of stem cells on micropatterned surfaces through the controlled single cell adhesion.

  2011cited by this paper
• A defined glycosaminoglycan-binding substratum for human pluripotent stem cells

  2010cited by this paper
• Geometric cues for directing the differentiation of mesenchymal stem cells

  2010cited by this paper
• Harnessing Traction-Mediated Manipulation of the Cell-Matrix Interface to Control Stem Cell Fate

  2010cited by this paper
• Mechanical regulation of cell function with geometrically modulated elastomeric substrates

  2010cited by this paper
• Polymeric substrates with tunable elasticity and nanoscopically controlled biomolecule presentation.

  2010cited by this paper
• Cell-Laden Hydrogel Constructs of Hyaluronic Acid, Collagen, and Laminin for Neural Tissue Engineering

  2010cited by this paper
• Intrinsic extracellular matrix properties regulate stem cell differentiation.

  2010cited by this paper
• Preparation of Hydrogel Substrates with Tunable Mechanical Properties

  2010cited by this paper
• Adipocyte extracellular matrix composition, dynamics and role in obesity

  2010cited by this paper
• The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells.

  2009cited by this paper
• Control of stem cell fate by physical interactions with the extracellular matrix.

  2009cited by this paper
• Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation.

  2008cited by this paper
• Substrate modulus directs neural stem cell behavior.

  2008cited by this paper
• Bone Marrow-Derived Human Mesenchymal Stem Cells Become Quiescent on Soft Substrates but Remain Responsive to Chemical or Mechanical Stimuli

  2008cited by this paper
• Directed cell growth on protein-functionalized hydrogel surfaces.

  2007cited by this paper
• Bone-marrow haematopoietic-stem-cell niches

  2006cited by this paper
• Matrix elasticity directs stem cell lineage specification.

  2006cited by this paper
• Bulk and micropatterned conjugation of extracellular matrix proteins to characterized polyacrylamide substrates for cell mechanotransduction assays.

  2005cited by this paper
• Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment.

  2004cited by this paper
• In vitro study of osteogenic differentiation of bone marrow stromal cells on heat-treated porcine trabecular bone blocks.

  2004cited by this paper
• Neurite branching on deformable substrates

  2002cited by this paper
• Cellular and Molecular Life Sciences REVIEW

  year unknowncited by this paper

• Chiral Hydroxyapatite Coatings for Improving Bone In‐Growth of Porous Tantalum Scaffold via FAK‐Notch1 Signaling Pathway

  2025cites this paper
• Decoding Hydrogel Porosity: Advancing the Structural Analysis of Hydrogels for Biomedical Applications

  2025cites this paper
• Advances in Nanohybrid Hydrogels for Wound Healing: From Functional Mechanisms to Translational Prospects

  2025cites this paper
• Stepwise Surface Engineering of Sr10‐HA‐g‐PBLG Porous Microspheres: Precise Functionalization for In Situ Scaffold Formation via Dynamic Crosslinking

  2025cites this paper
• Liquid-Crystalline Block Copolymers Comprising Cholesterol-Based Dendritic Moieties and Poly(L,L-lactide) Chains

  2025cites this paper
• Decellularized adipose-derived matrix from Superficial layers of abdominal adipose tissue exhibits superior capacity of adipogenesis compared to deep layers

  2024cites this paper
• Polishing methods for composites restoration: the influence on human gingival fibroblasts behaviour

  2024cites this paper
• Actin-based deformations of the nucleus control mouse multiciliated ependymal cell differentiation.

  2024cites this paper
• Design of Alginate/Gelatin Hydrogels for Biomedical Applications: Fine-Tuning Osteogenesis in Dental Pulp Stem Cells While Preserving Other Cell Behaviors

  2024cites this paper
• Pseudo‐3D Topological Alignments Regulate Mechanotransduction and Maturation of Smooth Muscle Cells

  2024cites this paper
• Unveiling the Topographic Cue Rendered by Micropatterns for Steering Cell Differentiation by Using Extrinsic Photobiomodulation

  2024cites this paper
• Actin-based deformations of the nucleus control multiciliated ependymal cell differentiation

  2024cites this paper
• Recent Advances in the Use of Stem Cells in Tissue Engineering and Adjunct Therapies for Tendon Reconstruction and Future Perspectives

  2024cites this paper
• Fabrication of chitin-fibrin hydrogels to construct the 3D artificial extracellular matrix scaffold for vascular regeneration and cardiac tissue engineering.

  2024cites this paper
• Controlling placental spheroid growth and phenotype using engineered synthetic hydrogel matrices.

  2024cites this paper
• Hydrophilic Components as Key Active Ingredients in Adipose‐Derived Matrix Bioscaffolds for Inducing Fat Regeneration

  2024cites this paper
• Characterization of MSCs expressing islet neogenesis associated protein (INGAP): INGAP secretion and cell survival in vitro and in vivo

  2024cites this paper
• Controlling differentiation of stem cells via bioactive disordered cues.

  2023cites this paper
• Mechanotransduction in tissue engineering: Insights into the interaction of stem cells with biomechanical cues.

  2023cites this paper
• Multiscale Computational Framework to Investigate Integrin Mechanosensing and Cell Adhesion

  2023cites this paper
• What are the key mechanical mechanisms governing integrin-mediated cell migration in three-dimensional fiber networks?

  2023cites this paper
• Fabrication of micro-nano patterned materials mimicking the topological structure of extracellular matrix for biomedical applications

  2023cites this paper
• Stem Cell Applications and Tenogenic Differentiation Strategies for Tendon Repair

  2023cites this paper
• One-Pot Synthesis of Double-Network PEG/Collagen Hydrogel for Enhanced Adipogenic Differentiation and Retrieval of Adipose-Derived Stem Cells

  2023cites this paper
• Harvest of Cell-Only Muscle Fibers Using Thermally Expandable Hydrogels with Adhesive Patterns

  2023cites this paper
• A Hierarchical Mechanotransduction System: From Macro to Micro

  2023cites this paper
• Soft Hydrogel Environments that Facilitate Cell Spreading and Aggregation Preferentially Support Chondrogenesis of Adult Stem Cells.

  2022cites this paper
• Simulated confluence on micropatterned substrates correlates responses regulating cellular differentiation

  2022cites this paper
• Comparative analysis of protein-protein interaction networks in neural differentiation mechanisms.

  2022cites this paper
• Superparamagnetic Iron Oxide Nanoparticles and Static Magnetic Field Regulate Neural Stem Cell Proliferation

  2022cites this paper
• Influence of extracellular cues of hydrogel biomaterials on stem cell fate

  2022cites this paper
• Strategies for improving adipose-derived stem cells for tissue regeneration

  2022cites this paper
• Early committed polarization of intracellular tension in response to cell shape determines the osteogenic differentiation of mesenchymal stromal cells

  2022cites this paper
• Morphological control enables nanometer-scale dissection of cell-cell signaling complexes

  2022cites this paper
• The Application of Cartilage Tissue Engineering with Cell-Laden Hydrogel in Plastic Surgery: A Systematic Review

  2021cites this paper
• Injectable AuNP-HA matrix with localized stiffness enhances the formation of gap junction in engrafted human induced pluripotent stem cell-derived cardiomyocytes and promotes cardiac repair.

  2021cites this paper
• Structural aspects controlling the mechanical and biological properties of tough, double network hydrogels.

  2021cites this paper
• Extracellular vesicles derived from T-cell acute lymphoblastic leukemia inhibit osteogenic differentiation of bone marrow mesenchymal stem cells via miR-34a-5p.

  2021cites this paper
• Fabrication of Stiffness Gradient Nanocomposite Hydrogels for Mimicking Cell Microenvironment

  2021cites this paper
• Engineering Hydrogels for Personalized Disease Modeling and Regenerative Medicine.

  2021cites this paper
• Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification

  2021cites this paper
• The influence of reduced graphene oxide on stem cells: a perspective in peripheral nerve regeneration

  2021cites this paper
• Defined Microenvironments Trigger In Vitro Gastrulation in Human Pluripotent Stem Cells

  2021cites this paper
• Compounded topographical and physicochemical cueing by micro-engineered chitosan substrates on rat dorsal root ganglion neurons and human mesenchymal stem cells.

  2021cites this paper
• Tuning the response of fluid filled hydrogel core-shell structures.

  2021cites this paper
• Magnetic Nanocomposite Hydrogels for Directing Myofibroblast Activity in Adipose‐Derived Stem Cells

  2021cites this paper
• Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation

  2021cites this paper
• Elastin-inspired supramolecular hydrogels: a multifaceted extracellular matrix protein in biomedical engineering.

  2021cites this paper
• Autologous Induced Pluripotent Stem Cell–Based Cell Therapies: Promise, Progress, and Challenges

  2021cites this paper
• Controlled Growth Factor Delivery and Cyclic Stretch Induces a Smooth Muscle Cell-like Phenotype in Adipose-Derived Stem Cells

  2021cites this paper
• Engineered Peptide-Functionalized Hydrogels Modulate the RNA Transcriptome of Human Nucleus Pulposus Cells In Vitro

  2021cites this paper
• Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation

  2021cites this paper
• Post-decellularization techniques ameliorate cartilage decellularization process for tissue engineering applications

  2021cites this paper
• Modulating the physico-mechanical properties of polyacrylamide/gelatin hydrogels for tissue engineering application

  2021cites this paper
• Characterization of Gelatin/Gellan Gum/Glycol Chitosan Ternary Hydrogel for Retinal Pigment Epithelial Tissue Reconstruction Materials.

  2020cites this paper
• Micropatterning of Cells on Gold Surfaces for Biophysical Applications

  2020cites this paper
• Disentangling the fibrous microenvironment: designer culture models for improved drug discovery

  2020cites this paper
• Surface Patterning of Hydrogel Biomaterials to Probe and Direct Cell–Matrix Interactions

  2020cites this paper
• Modulating Alginate Hydrogels for Improved Biological Performance as Cellular 3D Microenvironments

  2020cites this paper
• Customized hydrogel substrates for serum-free expansion of functional hMSCs.

  2020cites this paper
• Biofabrication of endothelial cell, dermal fibroblast, and multilayered keratinocyte layers for skin tissue engineering

  2020cites this paper
• Hepatic Differentiation of Stem Cells in 2D and 3D Biomaterial Systems

  2020cites this paper
• Mechanical Adaptations of Epithelial Cells on Various Protruded Convex Geometries

  2020cites this paper
• ZnO/Nanocarbons-Modified Fibrous Scaffolds for Stem Cell-Based Osteogenic Differentiation.

  2020cites this paper
• High‐Throughput Screening and Hierarchical Topography‐Mediated Neural Differentiation of Mesenchymal Stem Cells

  2020cites this paper
• A practical guide to microfabrication and patterning of hydrogels for biomimetic cell culture scaffolds

  2020cites this paper
• Emulating Human Tissues and Organs: A Bioprinting Perspective Toward Personalized Medicine

  2020cites this paper
• Verteporfin treatment controls morphology, phenotype, and global gene expression for cells of the human nucleus pulposus

  2020cites this paper
• The role of Piezo proteins and cellular mechanosensing in tuning the fate of transplanted stem cells

  2020cites this paper
• Mechanical Cues Regulating Proangiogenic Potential of Human Mesenchymal Stem Cells through YAP-Mediated Mechanosensing.

  2020cites this paper
• Nanoparticle encapsulated core-shell hydrogel for on-site BMSCs delivery protects from iron overload and enhances functional recovery.

  2020cites this paper
• Comparison of Extracellular Matrix (ECM) of Normal and D-Galactosamine-Induced Mice Model of Liver Injury Before and After Liver Decellularization

  2020cites this paper
• Cell seeding simulation on micropatterned islands shows cell density depends on area to perimeter ratio, not on island size or shape.

  2020cites this paper
• In Vitro Evaluation of the Influence of Substrate Mechanics on Matrix-Assisted Human Chondrocyte Transplantation

  2020cites this paper
• Multi-functional biomaterials: combining materials modification strategies for engineering of cell contacting surfaces.

  2020cites this paper
• Engineering approaches to control and design the in vitro environment towards the reconstruction of organs

  2020cites this paper
• Cells for Cartilage Regeneration

  2020cites this paper
• Stem Cell Mechanobiology and the Role of Biomaterials in Governing Mechanotransduction and Matrix Production for Tissue Regeneration

  2020cites this paper
• Glycogen as a Cross-Linking Agent of Collagen and Nanohydroxyapatite To Form Hydrogels for bMSC Differentiation

  2020cites this paper
• Gradient and Dynamic Hydrogel Materials to Probe Dynamics in Cancer Stem Cell Phenotypes

  2020cites this paper
• A multivalent polyanion-dispersed carbon nanotube toward highly bioactive nanostructured fibrous stem cell scaffolds

  2019cites this paper
• A comparative study of the behavior of neural progenitor cells in extrusion-based in vitro hydrogel models

  2019cites this paper
• Stem Cell Instruction via Appropriate Geometry and Local Curvature of Microstructured Polymeric Substrates

  2019cites this paper
• Mechanically tunable, human mesenchymal stem cell viable poly(ethylene glycol)-oxime hydrogels with invariant precursor composition, concentration, and stoichiometry.

  2019cites this paper
• Deformable Biomaterials Based on Ultralong Hydroxyapatite Nanowires.

  2019cites this paper
• Quasi-3D morphology and modulation of focal adhesions of human adult stem cells through combinatorial concave elastomeric surfaces with varied stiffness.

  2019cites this paper
• Extracellular matrix micropatterning technology for whole cell cryogenic electron microscopy studies

  2019cites this paper
• Nanoparticle-Based Hybrid Scaffolds for Deciphering the Role of Multi-Modal Cues in Cardiac Tissue Engineering.

  2019cites this paper
• Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands.

  2019cites this paper
• Counting growth factors in single cells with infrared quantum dots to measure discrete stimulation distributions

  2019cites this paper
• Peptide-modified, hyaluronic acid-based hydrogels as a 3D culture platform for neural stem/progenitor cell engineering.

  2019cites this paper
• Mussel-inspired injectable hydrogel and its counterpart for actuating proliferation and neuronal differentiation of retinal progenitor cells.

  2019cites this paper
• Polyamidoamine dendrimer-PEG hydrogel and its mechanical property on differentiation of mesenchymal stem cells

  2019cites this paper
• Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment

  2019cites this paper
• The effects of electrical stimulation mediated by conductive polymers on in vitro models of schizophrenia

  2019cites this paper
• Biomolecule-Conjugated Macroporous Hydrogels for Biomedical Applications.

  2019cites this paper
• Mechanophysical Cues in Extracellular Matrix Regulation of Cell Behavior

  2019cites this paper
• Nanoscale Multiparametric Imaging of Peptide-Assembled Nanofibrillar Hydrogels by Atomic Force Microscopy

  2019influential citation
• Physical Stimulation in Tissue-Engineering

  2019cites this paper
• Insight into Mechanobiology: How Stem Cells Feel Mechanical Forces and Orchestrate Biological Functions

  2019cites this paper