The 2′-O-methylation status of a single guanosine controls transfer RNA–mediated Toll-like receptor 7 activation or inhibition

Stefanie Jöckel,Gernot Nees,Romy Sommer,Yang Zhao,Dmitry Cherkasov,H. Hori,Gundi Ehm,M. Schnare,Marianne Nain,A. Kaufmann,S. Bauer

Published 2012 in Journal of Experimental Medicine

ABSTRACT

Bacterial transfer RNA can suppress the immunostimulatory activity of other bacterial tRNAs as a result of the presence of a guanosine modification.

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