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Tumour Evolution Driving Genome Instability, Immune Interactions, and Response to Radiotherapy

G. Seed,France Truong,Rahma Riahi,Ben O'Leary

Published 2025 in Cancer Journal

ABSTRACT

This review article explores the role of immuno-radiotherapy in the context of genome instability and tumour evolution. Genomic changes in tumours exist in a delicate balance with the immune system, offering evolutionary pathways to adapt and grow but risking provoking an immune response. Rapid developments across both immunotherapy and radiotherapy have raised questions about the potential benefits combination therapy, and how best to identify ideal treatment populations. Here we discuss foundational studies of genomic instability and tumour evolution, how these paradigms translate into immune surveillance and evasion, and subsequently go on to explore recent preclinical and clinical studies of both treatment modalities. Understanding how cancers evolve in the context of the immune system could provide a key insight in delivering better therapies that could overcome treatment resistance.

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