Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease

Tz-Chuen Ju,Hui-Mei Chen,Jiun‐Tsai Lin,Ching-Pang Chang,Wei-Cheng Chang,Jheng-Jie Kang,Cheng-Pu Sun,Michie Tao,P. Tu,Chen Chang,D. Dickson,Y. Chern

Published 2011 in Journal of Cell Biology

ABSTRACT

Nuclear accumulation of AMPK-α1 induces brain atrophy, neuronal loss, and formation of Htt aggregates in a Huntington’s disease model.

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