Notch signalling in T‐cell lymphoblastic leukaemia/lymphoma and other haematological malignancies

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Pathology

• Publication date

  2011-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/path.2789PMID 20967796PMCID PMC2996483
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Direct inhibition of the NOTCH transcription factor complex

  2010cited by this paper
• Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

  2010cited by this paper
• Therapeutic antibody targeting of individual Notch receptors

  2010cited by this paper
• Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

  2010cited by this paper
• Genetic inactivation of Ikaros is a rare event in human T-ALL.

  2010cited by this paper
• Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex.

  2010cited by this paper
• Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

  2010cited by this paper
• Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

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• γ‐Secretase‐Dependent Cleavage Initiates Notch Signaling from the Plasma Membrane

  2010cited by this paper
• Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents

  2010cited by this paper
• The Mastermind-like 1 (MAML1) Co-activator Regulates Constitutive NF-κB Signaling and Cell Survival*

  2010cited by this paper
• Notch signaling in the immune system.

  2010cited by this paper
• BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning.

  2010cited by this paper
• The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.

  2010cited by this paper
• NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study.

  2009cited by this paper
• Targeting the Notch1 and mTOR pathways in a mouse T-ALL model.

  2009cited by this paper
• Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

  2009cited by this paper
• The canonical Notch signaling pathway: unfolding the activation mechanism.

  2009cited by this paper
• CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia

  2009cited by this paper
• The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T- cell acute lymphoblastic leukemia: A report from the Children's Oncology Group

  2009cited by this paper
• Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.

  2009cited by this paper
• FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non‐Hodgkin lymphoma

  2009cited by this paper
• Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

  2009cited by this paper
• Angiogenesis: a team effort coordinated by notch.

  2009cited by this paper
• Hes1 Potentiates T Cell Lymphomagenesis by Up-Regulating a Subset of Notch Target Genes

  2009cited by this paper
• The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.

  2009cited by this paper
• Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol.

  2009cited by this paper
• Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells.

  2009cited by this paper
• CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

  2009cited by this paper
• NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity.

  2009cited by this paper
• Direct inhibition of the NOTCH transcription factor complex

  2009cited by this paper
• Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.

  2009cited by this paper
• Gain‐of‐function mutations and copy number increases of Notch2 in diffuse large B‐cell lymphoma

  2009cited by this paper
• Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage*

  2009cited by this paper
• Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3*

  2008cited by this paper
• Ikaros Directly Represses the Notch Target Gene Hes1 in a Leukemia T Cell Line

  2008cited by this paper
• Mutational and energetic studies of Notch 1 transcription complexes.

  2008cited by this paper
• Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

  2008cited by this paper
• Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1

  2008cited by this paper
• K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.

  2008cited by this paper
• Notch signaling specifies megakaryocyte development from hematopoietic stem cells.

  2008cited by this paper
• Gamma-secretase inhibitors reverse glucocorticoid resistance in T-ALL

  2008cited by this paper
• Leukemia-associated NOTCH 1 alleles are weak tumor initiators but accelerate Kras – initiated leukemia

  2008cited by this paper
• NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.

  2008cited by this paper
• Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice

  2008cited by this paper
• Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.

  2008cited by this paper
• Delta-like 4 is indispensable in thymic environment specific for T cell development

  2008cited by this paper
• Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.

  2008cited by this paper
• Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences

  2008cited by this paper
• Ikaros Regulates Notch Target Gene Expression in Developing Thymocytes1

  2008cited by this paper
• Ikaros Represses the Transcriptional Response to Notch Signaling in T-Cell Development

  2008cited by this paper
• Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma

  2008cited by this paper
• The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

  2007cited by this paper
• Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.

  2007cited by this paper
• Predominant Interaction of Both Ikaros and Helios with the NuRD Complex in Immature Thymocytes*

  2007cited by this paper
• Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

  2007cited by this paper
• Identification of a T lineage-committed progenitor in adult blood.

  2007cited by this paper
• The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

  2007cited by this paper
• Gain-of-Function Mutations and Copy Number Increases of Notch2 in Diffuse Large B-Cell Lymphoma.

  2007cited by this paper
• Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch.

  2007cited by this paper
• Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription

  2007cited by this paper
• Structural basis for autoinhibition of Notch

  2007cited by this paper
• FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

  2007cited by this paper
• Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia

  2007cited by this paper
• Rbm15 Modulates Notch-Induced Transcriptional Activation and Affects Myeloid Differentiation

  2007cited by this paper
• Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice.

  2007cited by this paper
• Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.

  2007cited by this paper
• Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

  2007cited by this paper
• Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

  2007cited by this paper
• Notch3 and the Notch3‐upregulated RNA‐binding protein HuD regulate Ikaros alternative splicing

  2007cited by this paper
• NOTCH1 Mutations in T-Cell Acute Lymphoblastic Leukemia: Prognostic Significance and Implication in Multifactorial Leukemogenesis

  2006cited by this paper
• The outcome of molecular-cytogenetic subgroups in pediatric T-cell acute lymphoblastic leukemia: a retrospective study of patients treated according to DCOG or COALL protocols.

  2006cited by this paper
• Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc

  2006cited by this paper
• NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway.

  2006cited by this paper
• Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma.

  2006cited by this paper
• Leukemia-Associated Mutations within the NOTCH1 Heterodimerization Domain Fall into at Least Two Distinct Mechanistic Classes

  2006cited by this paper
• Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

  2006cited by this paper
• Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias

  2006cited by this paper
• Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice

  2006cited by this paper
• Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.

  2006cited by this paper
• Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1

  2006cited by this paper
• c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.

  2006cited by this paper
• Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.

  2006cited by this paper
• NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

  2006cited by this paper
• RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.

  2005cited by this paper
• Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism

  2005cited by this paper
• RBP-Jκ/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes

  2005cited by this paper
• Mutations in NOTCH1 cause aortic valve disease

  2005cited by this paper
• Notch signaling controls the generation and differentiation of early T lineage progenitors

  2005cited by this paper
• Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

  2005cited by this paper
• Induction of apoptosis by proteasome inhibitors in B-CLL cells is associated with downregulation of CD23 and inactivation of Notch2

  2005cited by this paper
• Regulation of lymphoid development, differentiation, and function by the Notch pathway.

  2005cited by this paper
• Activating Notch1 mutations in mouse models of T-ALL.

  2005cited by this paper
• Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia

  2005cited by this paper
• Interleukin-7 in T-cell acute lymphoblastic leukemia: An extrinsic factor supporting leukemogenesis?

  2005cited by this paper
• The Anti-apoptotic Effect of Notch-1 Requires p56lck-dependent, Akt/PKB-mediated Signaling in T Cells*

  2004cited by this paper
• Jagged 1-induced Notch signaling drives proliferation of multiple myeloma cells

  2004cited by this paper
• Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development*

  2004cited by this paper
• Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells.

  2004cited by this paper
• Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.

  2004cited by this paper

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