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Carboxypeptidase A4: A Biomarker for Cancer Aggressiveness and Drug Resistance

Adeoluwa A Adeluola,M. Hossain,A. Amin

Published 2025 in Cancers

ABSTRACT

Simple Summary Cancer is the second leading cause of death in developed countries and the leading cause of death in the underdeveloped world with about 20 million new diagnoses and 9.7 million deaths worldwide. Identification of biomarkers governing tumor initiation, early diagnosis, aggressiveness, or drug response and resistance is critical to reduce the cancer burden and increase patient survival. Carboxypeptidases, including CPA4, are enzymes that cleave C-terminal peptide bonds in peptides and proteins. Many of these enzymes take part in carcinogenesis and drug response. CPA4 is an exopeptidase that cleaves peptide bonds at the C-terminal domain of peptides and proteins. This enzyme is overexpressed in many cancers and often associated with cancer aggressiveness and resistance to treatment. Targeting CPA4 could serve as a novel strategy to reduce cancer burden and improve drug response.

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