Metallocarboxypeptidases: emerging drug targets in biomedicine.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Current pharmaceutical design

• Publication date

  2007-01-31

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.2174/138161207780162980PMID 17311554
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of the Molecular Basis of the Drosophila Mutations in Carboxypeptidase D

  2006cited by this paper
• Mast Cells Can Enhance Resistance to Snake and Honeybee Venoms

  2006cited by this paper
• Generation of a Stable Activated Thrombin Activable Fibrinolysis Inhibitor Variant*

  2006cited by this paper
• Reduced pain sensitivity in mice lacking latexin, an inhibitor of metallocarboxypeptidases.

  2006cited by this paper
• Development of new fibrinolytic agents.

  2006cited by this paper
• Novel concepts of statin therapy for cardiovascular risk reduction in hypertension.

  2006cited by this paper
• Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down‐regulating fibrinolysis

  2006cited by this paper
• Structural basis of the resistance of an insect carboxypeptidase to plant protease inhibitors.

  2005cited by this paper
• Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin.

  2005cited by this paper
• The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode.

  2005cited by this paper
• Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin

  2005cited by this paper
• A Carboxypeptidase Inhibitor from the Tick Rhipicephalus bursa

  2005cited by this paper
• Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker.

  2005cited by this paper
• Mucosal adjuvants.

  2005cited by this paper
• Identification and distribution of mouse carboxypeptidase A-6.

  2005cited by this paper
• Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives.

  2005cited by this paper
• An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1.

  2005cited by this paper
• Thrombin-activatable fibrinolysis inhibitor.

  2004cited by this paper
• Generation and Characterization of a Highly Stable Form of Activated Thrombin-activable Fibrinolysis Inhibitor*

  2004cited by this paper
• The Intrinsic Threshold of the Fibrinolytic System Is Modulated by Basic Carboxypeptidases, but the Magnitude of the Antifibrinolytic Effect of Activated Thrombin-activable Fibrinolysis Inhibitor Is Masked by Its Instability*

  2004cited by this paper
• Thrombin activatable fibrinolysis inhibitor: Not just an inhibitor of fibrinolysis

  2004cited by this paper
• Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor

  2004cited by this paper
• Tethering: fragment-based drug discovery.

  2004cited by this paper
• Cooperation between Mast Cell Carboxypeptidase A and the Chymase Mouse Mast Cell Protease 4 in the Formation and Degradation of Angiotensin II*

  2004cited by this paper
• Thrombin-activatable fibrinolysis inhibitor and the risk for recurrent venous thromboembolism.

  2004cited by this paper
• Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity.

  2004cited by this paper
• Secondary binding site of the potato carboxypeptidase inhibitor. Contribution to its structure, folding, and biological properties.

  2004cited by this paper
• Specific tumour localisation of a huA33 antibody--carboxypeptidase A conjugate and activation of methotrexate-phenylalanine.

  2004cited by this paper
• Arthritis is linked to local and systemic activation of coagulation and fibrinolysis pathways

  2003cited by this paper
• Stabilization Versus Inhibition of TAFIa by Competitive Inhibitors in Vitro *

  2003cited by this paper
• Neuropeptide-processing carboxypeptidases.

  2003cited by this paper
• Carboxypeptidase Z (CPZ) modulates Wnt signaling and regulates the development of skeletal elements in the chicken

  2003cited by this paper
• Structure and dynamics of the potato carboxypeptidase inhibitor by 1H and 15N NMR

  2003cited by this paper
• Reversible inhibitors of TAFIa can both promote and inhibit fibrinolysis

  2003cited by this paper
• Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI

  2003cited by this paper
• The novel imprinted carboxypeptidase A4 gene (CPA4) in the 7q32 imprinting domain

  2003cited by this paper
• Thrombin Activatable Fibrinolysis Inhibitor (TAFI) at the Interface between Coagulation and Fibrinolysis

  2003cited by this paper
• Thrombin Activatable Fibrinolysis Inhibitor, a Potential Regulator of Vascular Inflammation*

  2003cited by this paper
• The Unfolding Pathway of Leech Carboxypeptidase Inhibitor*

  2002cited by this paper
• Co-segregation of thrombophilic disorders in factor V Leiden carriers; the contributions of factor VIII, factor XI, thrombin activatable fibrinolysis inhibitor and lipoprotein(a) to the absolute risk of venous thromboembolism.

  2002cited by this paper
• Characterization of Drosophila Carboxypeptidase D*

  2002cited by this paper
• Two Naturally Occurring Variants of TAFI (Thr-325 and Ile-325) Differ Substantially with Respect to Thermal Stability and Antifibrinolytic Activity of the Enzyme*

  2002cited by this paper
• A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours

  2002cited by this paper
• Rational structure-based design of a novel carboxypeptidase R inhibitor.

  2002cited by this paper
• Sulfamide-based inhibitors for carboxypeptidase A. Novel type transition state analogue inhibitors for zinc proteases.

  2002cited by this paper
• In vivo regulation of plasminogen function by plasma carboxypeptidase B.

  2002cited by this paper
• Insight into the stereochemistry in the inhibition of carboxypeptidase A with N-(hydroxyaminocarbonyl)phenylalanine: binding modes of an enantiomeric pair of the inhibitor to carboxypeptidase A.

  2002cited by this paper
• Identification and Characterization of Three Members of the Human Metallocarboxypeptidase Gene Family*

  2002cited by this paper
• Plasmin-mediated activation and inactivation of thrombin-activatable fibrinolysis inhibitor.

  2002cited by this paper
• Serum levels of procarboxypeptidase B and its activation peptide in patients with acute pancreatitis and non-pancreatic diseases

  2002cited by this paper
• A peptidase gene in chromosome 8q is disrupted by a balanced translocation in a duane syndrome patient.

  2002cited by this paper
• Inactivation of C3a and C5a Octapeptides by Carboxypeptidase R and Carboxypeptidase N

  2002cited by this paper
• Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life.

  2002cited by this paper
• Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.

  2002cited by this paper
• Carboxypeptidases from A to Z: implications in embryonic development and Wnt binding

  2001cited by this paper
• Association of a single nucleotide polymorphism in CPB2 encoding the thrombin‐activable fibrinolysis inhibitor (TAFI) with blood pressure

  2001cited by this paper
• The Defective Down Regulation of Fibrinolysis in Haemophilia A Can Be Restored by Increasing the TAFI Plasma Concentration

  2001cited by this paper
• Metallocarboxypeptidase Z is dynamically expressed in mouse development.

  2001cited by this paper
• Strategies for enzyme/prodrug cancer therapy.

  2001cited by this paper
• The Crystal Structure of the Inhibitor-complexed Carboxypeptidase D Domain II and the Modeling of Regulatory Carboxypeptidases*

  2001cited by this paper
• Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity

  2001cited by this paper
• Identification and nuclear localization of a novel prolactin and cytokine-responsive carboxypeptidase D.

  2001cited by this paper
• Impaired Abdominal Wall Development and Deficient Wound Healing in Mice Lacking Aortic Carboxypeptidase-Like Protein

  2001cited by this paper
• Roles of Thermal Instability and Proteolytic Cleavage in Regulation of Activated Thrombin-activable Fibrinolysis Inhibitor*

  2000cited by this paper
• Contribution of C-tail residues of potato carboxypeptidase inhibitor to the binding to carboxypeptidase A A mutagenesis analysis.

  2000cited by this paper
• Carboxypeptidase Z Is Present in the Regulated Secretory Pathway and Extracellular Matrix in Cultured Cells and in Human Tissues*

  2000cited by this paper
• Regenerating motor neurons express Nna1, a novel ATP/GTP-binding protein related to zinc carboxypeptidases.

  2000cited by this paper
• An inhibitor of activated thrombin-activatable fibrinolysis inhibitor potentiates tissue-type plasminogen activator-induced thrombolysis in a rabbit jugular vein thrombolysis model.

  2000cited by this paper
• Inactivation of Active Thrombin-activable Fibrinolysis Inhibitor Takes Place by a Process That Involves Conformational Instability Rather Than Proteolytic Cleavage*

  2000cited by this paper
• Thrombin-activable Fibrinolysis Inhibitor Attenuates (DD)E-mediated Stimulation of Plasminogen Activation by Reducing the Affinity of (DD)E for Tissue Plasminogen Activator

  2000cited by this paper
• Catalytic activity of an in vivo tumor targeted anti‐CEA scFv::carboxypeptidase G2 fusion protein

  2000cited by this paper
• The Unfolding Pathway and Conformational Stability of Potato Carboxypeptidase Inhibitor*

  2000cited by this paper
• Plasma Procarboxypeptidase U in Men with Symptomatic Coronary Artery Disease

  2000cited by this paper
• Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-alpha-peptide prodrugs.

  2000cited by this paper
• Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2

  2000cited by this paper
• Metallocarboxypeptidases and their protein inhibitors. Structure, function and biomedical properties.

  2000cited by this paper
• Thrombin activatable fibrinolysis inhibitor and the risk for deep vein thrombosis.

  2000cited by this paper
• Localization of Metallocarboxypeptidase D in AtT-20 Cells

  1999cited by this paper
• Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material

  1999cited by this paper
• Carboxypeptidase D is a potential candidate to carry out redundant processing functions of carboxypeptidase E based on comparative distribution studies in the rat central nervous system.

  1999cited by this paper
• Identification of Mouse CPX-1, a Novel Member of the Metallocarboxypeptidase Gene Family with Highest Similarity to CPX-2

  1999cited by this paper
• Crystal structure of avian carboxypeptidase D domain II: a prototype for the regulatory metallocarboxypeptidase subfamily

  1999cited by this paper
• Characterization of the Enzymatic Properties of the First and Second Domains of Metallocarboxypeptidase D*

  1999cited by this paper
• Toward an Enzyme/Prodrug Strategy for Cancer Gene Therapy: Endogenous Activation of Carboxypeptidase A Mutants by the PACE/Furin Family of Propeptidases

  1999cited by this paper
• Factor XI Dependent and Independent Activation of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) in Plasma Associated with Clot Formation

  1999cited by this paper
• 2-Benzyl-2-methylsuccinic acid as inhibitor for carboxypeptidase A. synthesis and evaluation.

  1999cited by this paper
• Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT).

  1999cited by this paper
• Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW1031 and GW1843.

  1999cited by this paper
• Glu300 of Rat Carboxypeptidase E Is Essential for Enzymatic Activity but Not Substrate Binding or Routing to the Regulated Secretory Pathway*

  1999cited by this paper
• Mapping the Pro-region of Carboxypeptidase B by Protein Engineering

  1999cited by this paper
• A novel approach to arterial thrombolysis.

  1999cited by this paper
• A Carboxypeptidase Inhibitor from the Medical Leech Hirudo medicinalis

  1998cited by this paper
• Characterization of the wound-induced metallocarboxypeptidase inhibitor from potato. cDNA sequence, induction of gene expression, subcellular immunolocalization and potential roles of the C-terminal propeptide.

  1998cited by this paper
• Both Cellular and Soluble Forms of Thrombomodulin Inhibit Fibrinolysis by Potentiating the Activation of Thrombin-activable Fibrinolysis Inhibitor*

  1998cited by this paper
• Protein similarities beyond disulphide bridge topology.

  1998cited by this paper
• Potato Carboxypeptidase Inhibitor, a T-knot Protein, Is an Epidermal Growth Factor Antagonist That Inhibits Tumor Cell Growth*

  1998cited by this paper
• Identification of Mouse CPX-2, a Novel Member of the Metallocarboxypeptidase Gene Family: cDNA Cloning, mRNA Distribution, and Protein Expression and Characterization

  1998cited by this paper
• A Study of the Mechanism of Inhibition of Fibrinolysis by Activated Thrombin-activable Fibrinolysis Inhibitor*

  1998cited by this paper
• Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice.

  1997cited by this paper
• Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins.

  1997cited by this paper

• Association of Carboxypeptidase B2 Gene Polymorphisms With Graft Loss in Kidney Transplantation

  2026cites this paper
• Surface loops may provide additional function necessary for enzyme-to-pseudoenzyme transition in the fungal metallocarboxypeptidase family.

  2026cites this paper
• Deficiencies of CPN and CPB2 have opposite effects in a virulent mouse E. coli sepsis model.

  2025cites this paper
• Identification of dietary protein utilization traits related SNPs and genes in brown-marbled grouper (Epinephelus fuscoguttatus)

  2025cites this paper
• Revisiting Fused‐Pyrrolo‐1,10‐Phenanthroline Derivatives: Novel Transformations and Stability Studies

  2025cites this paper
• Carboxypeptidase A4: A Biomarker for Cancer Aggressiveness and Drug Resistance

  2025cites this paper
• Targeting carboxypeptidase A/B activity with the phosphinic inhibitor C28 reduces the asthmatic response in a mouse model of house dust mite-induced asthma

  2025cites this paper
• Factors Impacting the Gastrointestinal Digestive Enzymes Fate of Magnesium Oxide Clusters: In Silico Characterization

  2025cites this paper
• Inactive metallopeptidase homologs: the secret lives of pseudopeptidases

  2024cites this paper
• Insights into the Activation Mechanism of Bm-CPA: Implications for Insect Molting Regulation.

  2024cites this paper
• Isolation and Characterization of NpCI, a New Metallocarboxypeptidase Inhibitor from the Marine Snail Nerita peloronta with Anti-Plasmodium falciparum Activity

  2023cites this paper
• The Purification of Human Carboxypeptidase O.

  2023cites this paper
• Carboxypeptidase A3—A Key Component of the Protease Phenotype of Mast Cells

  2022cites this paper
• Enhanced Production of ECM Proteins for Pharmaceutical Applications Using Mammalian Cells and Sodium Heparin Supplementation

  2022cites this paper
• In vitro and in silico characterization of a novel glutamate carboxypeptidase from Cohnella sp. A01.

  2022cites this paper
• Phosphinic Peptides as Tool Compounds for the Study of Pharmacologically Relevant Zn-Metalloproteases.

  2022cites this paper
• Identification and characterization of a wolfberry carboxypeptidase inhibitor from Lycium barbarum.

  2021cites this paper
• Biotechnological, biomedical, and agronomical applications of plant protease inhibitors with high stability: A systematic review.

  2020cites this paper
• Substrate Specificity and Structural Modeling of Human Carboxypeptidase Z: A Unique Protease with a Frizzled-Like Domain

  2020cites this paper
• Biochemical and genetic analysis of Ecm14, a conserved fungal pseudopeptidase

  2020cites this paper
• Carboxypeptidase A6 was identified and validated as a novel potential biomarker for predicting the occurrence of active ulcerative colitis

  2020cites this paper
• Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes.

  2019cites this paper
• Characterization, Recombinant Production and Structure-Function Analysis of NvCI, A Picomolar Metallocarboxypeptidase Inhibitor from the Marine Snail Nerita versicolor

  2019cites this paper
• Discovery and characterization of novel cysteine-rich peptides in medicinal plants

  2018cites this paper
• Carboxypeptidase B2 and carboxypeptidase N in the crosstalk between coagulation, thrombosis, inflammation, and innate immunity

  2018cites this paper
• Structure of the carboxypeptidase B complex with N-sulfamoyl-L-phenylalanine – a transition state analog of non-specific substrate

  2018cites this paper
• Biochemical and MALDI-TOF Mass Spectrometric Characterization of a Novel Native and Recombinant Cystine Knot Miniprotein from Solanum tuberosum subsp. andigenum cv. Churqueña

  2018cites this paper
• Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues

  2018cites this paper
• Multiple Architectures and Mechanisms of Latency in Metallopeptidase Zymogens.

  2018cites this paper
• Biochemical characterization of the YBPCI miniprotein, the first carboxypeptidase inhibitor isolated from Yellow Bell Pepper (Capsicum annuum L). A novel contribution to the knowledge of miniproteins stability.

  2018cites this paper
• Identification of Carboxypeptidase Substrates by C-Terminal COFRADIC.

  2017cites this paper
• The effects of sex steroid hormones on the activities of basic carboxypeptidases in the hypothalamo–pituitary–adrenal system of male and female mice after stress

  2017cites this paper
• Plasticity in the Oxidative Folding Pathway of the High Affinity Nerita Versicolor Carboxypeptidase Inhibitor (NvCI)

  2017cites this paper
• Substrate specificity of human metallocarboxypeptidase D: Comparison of the two active carboxypeptidase domains

  2017cites this paper
• Analysis of Mammalian Carboxypeptidase O Expression Patterns

  2016cites this paper
• Characterization of a novel metallocarboxypeptidase from Streptomyces cinnamoneus TH-2

  2016cites this paper
• Microplate Assay to Study Carboxypeptidase A Inhibition in Andean Potatoes

  2016cites this paper
• Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of carboxypeptidase A4 (CPA4) – a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity

  2016cites this paper
• Sequence-independent characterization of viruses based on the pattern of viral small RNAs produced by the host

  2016cites this paper
• Biochemical characterization of a novel carboxypeptidase inhibitor from a variety of Andean potatoes.

  2015cites this paper
• Sequence-independent characterization of viruses based on the pattern of viral small RNAs produced by the host

  2015cites this paper
• Mast cell recruitment and activation as measures of cyathostomin burden

  2015cites this paper
• The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids

  2014cites this paper
• Characterization of two metallocarboxypeptidases of M14D subfamily from bacterial and human origin

  2014cites this paper
• Amyloid Formation by Human Carboxypeptidase D Transthyretin-like Domain under Physiological Conditions*

  2014cites this paper
• Structural modeling and functional characterization of mammalian cytosolic carboxypeptidases 2 and 3

  2014cites this paper
• C-terminomics Screen for Natural Substrates of Cytosolic Carboxypeptidase 1 Reveals Processing of Acidic Protein C termini*

  2014cites this paper
• Chapter 296 – Carboxypeptidase B

  2013cites this paper
• Quantitative Peptidomics of Purkinje Cell Degeneration Mice

  2013cites this paper
• A noncanonical mechanism of carboxypeptidase inhibition revealed by the crystal structure of the Tri-Kunitz SmCI in complex with human CPA4.

  2013cites this paper
• Proteome-derived Peptide Libraries to Study the Substrate Specificity Profiles of Carboxypeptidases*

  2013cites this paper
• Secreted proteases of Trypanosoma brucei gambiense: Possible targets for sleeping sickness control?

  2013cites this paper
• Profiling of diet-induced neuropeptide changes in rat brain by quantitative mass spectrometry.

  2013cites this paper
• Metallocarboxypeptidases and their inhibitors: recent developments in biomedically relevant protein and organic ligands.

  2013cites this paper
• Compartmentalization of Proteolysis

  2013cites this paper
• Metallocarboxypeptidase G ( Porphyromonas gingivalis )

  2013cites this paper
• The novel structure of a cytosolic M14 metallocarboxypeptidase (CCP) from Pseudomonas aeruginosa: a model for mammalian CCPs

  2012influential citation
• A structural and functional analysis of Nna1 in Purkinje cell degeneration (pcd) mice

  2012cites this paper
• Characterization of the M32 metallocarboxypeptidase of Trypanosoma brucei: differences and similarities with its orthologue in Trypanosoma cruzi.

  2012cites this paper
• Crystal Structure of Novel Metallocarboxypeptidase Inhibitor from Marine Mollusk Nerita versicolor in Complex with Human Carboxypeptidase A4*

  2012cites this paper
• Evaluation of Database Search Programs for Accurate Detection of Neuropeptides in Tandem Mass Spectrometry Experiments

  2012cites this paper
• Post-translational Processing of Gastrointestinal Peptides

  2012cites this paper
• Using Small Globular Proteins to Study Folding Stability and Aggregation

  2012cites this paper
• Tri-domain Bifunctional Inhibitor of Metallocarboxypeptidases A and Serine Proteases Isolated from Marine Annelid Sabellastarte magnifica*

  2012cites this paper
• A standard orientation for metallopeptidases.

  2012cites this paper
• Kinetic and proteomic identification of protease inhibitors in marine invertebrates. Characterization of a carboxypeptidase inhibitor isolated from the mollusc nerita versicolor

  2012influential citation
• On the cutting edge of proprotein convertase pharmacology: from molecular concepts to clinical applications

  2011cites this paper
• Author ' s personal copy The substrate specificity of Metarhizium anisopliae and Bos taurus carboxypeptidases A : Insights into their use as tools for the removal of affinity tags

  2011cites this paper
• The substrate specificity of Metarhizium anisopliae and Bos taurus carboxypeptidases A: insights into their use as tools for the removal of affinity tags.

  2011cites this paper
• Quantitative peptidomics of mice lacking peptide-processing enzymes.

  2011cites this paper
• Expression of metallocarboxypeptidase inhibitors in Escherichia coli: effect of cysteine content and protein size in the secretory production of disulfide-bridged proteins

  2011influential citation
• Carboxypeptidase O Is a Glycosylphosphatidylinositol-anchored Intestinal Peptidase with Acidic Amino Acid Specificity*

  2011cites this paper
• Effects of the Prosegment and pH on the Activity of PCSK9

  2010cites this paper
• Flexibility of the Thrombin-activatable Fibrinolysis Inhibitor Pro-domain Enables Productive Binding of Protein Substrates*

  2010cites this paper
• The Proprotein Convertase PC7

  2010cites this paper
• Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior

  2010cites this paper
• Insights into the molecular inactivation mechanism of human activated thrombin‐activatable fibrinolysis inhibitor

  2010cites this paper
• Structure–Function Analysis of the Short Splicing Variant Carboxypeptidase Encoded by Drosophila melanogaster silver

  2010influential citation
• Carboxypeptidase A6 in Zebrafish Development and Implications for VIth Cranial Nerve Pathfinding

  2010cites this paper
• Substrate Specificity of Human Carboxypeptidase A6*

  2010cites this paper
• The X‐Ray Structure of Carboxypeptidase A Inhibited by a Thiirane Mechanism‐Based Inhibitor

  2010cites this paper
• CCP1/Nna1 functions in protein turnover in mouse brain: Implications for cell death in Purkinje cell degeneration mice

  2010cites this paper
• Metalloproteases and the degradome.

  2010cites this paper
• Characterization of the Substrate Specificity of Human Carboxypeptidase A4 and Implications for a Role in Extracellular Peptide Processing*

  2010cites this paper
• Processing of peptide and hormone precursors at the dibasic cleavage sites

  2009cites this paper
• Aromatic Organic Compounds as Scaffolds for Metallocarboxypeptidase Inhibitor Design

  2009cites this paper
• Novel insights into the biological function of mast cell carboxypeptidase A.

  2009cites this paper
• Discovery and characterization of small molecular weight metallocarboxypeptidase inhibitors

  2009cites this paper
• A novel metallocarboxypeptidase‐like enzyme from the marine annelid Sabellastarte magnifica– a step into the invertebrate world of proteases

  2009cites this paper
• Designing out disulfide bonds of leech carboxypeptidase inhibitor: implications for its folding, stability and function.

  2009cites this paper
• Site-Specific Carboxypeptidase B1 Tyrosine Nitration and Pathophysiological Implications following Its Physical Association with Nitric Oxide Synthase-3 in Experimental Sepsis1

  2009cites this paper
• Experimental Sepsis Association with Nitric Oxide Synthase-3 in Implications following Its Physical Nitration and Pathophysiological Site-Specific Carboxypeptidase B1 Tyrosine

  2009cites this paper
• Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice.

  2009cites this paper
• Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets

  2009cites this paper
• Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite

  2009influential citation
• Sepsis Association with Nitric Oxide Synthase-3 in Implications following Its Physical Nitration and Pathophysiological Site-Specific Carboxypeptidase B 1 Tyrosine

  2009cites this paper
• Insights into the two-domain architecture of the metallocarboxypeptidase inhibitor from the Ascaris parasite inferred from the mechanism of its oxidative folding.

  2009cites this paper
• Extracellular proteases as targets for drug development.

  2009cites this paper
• Structure and Mechanism of Metallocarboxypeptidases

  2008cites this paper
• The Regulated Cell Surface Zymogen Activation of the Proprotein Convertase PC5A Directs the Processing of Its Secretory Substrates*

  2008cites this paper