Stratification of unresponsive patients by an independently validated index of brain complexity

S. Casarotto,A. Comanducci,M. Rosanova,S. Sarasso,M. Fecchio,M. Napolitani,A. Pigorini,Adenauer G Casali,P. Trimarchi,M. Boly,O. Gosseries,O. Bodart,F. Curto,C. Landi,M. Mariotti,G. Devalle,Steven Laureys,G. Tononi,M. Massimini

Published 2016 in Annals of Neurology

ABSTRACT

Validating objective, brain‐based indices of consciousness in behaviorally unresponsive patients represents a challenge due to the impossibility of obtaining independent evidence through subjective reports. Here we address this problem by first validating a promising metric of consciousness—the Perturbational Complexity Index (PCI)—in a benchmark population who could confirm the presence or absence of consciousness through subjective reports, and then applying the same index to patients with disorders of consciousness (DOCs).

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