The Old World and New World Alphaviruses Use Different Virus-Specific Proteins for Induction of Transcriptional Shutoff

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Virology

• Publication date

  2006-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.02073-06PMID 17108023PMCID PMC1865960
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The efficient packaging of Venezuelan equine encephalitis virus-specific RNAs into viral particles is determined by nsP1-3 synthesis.

  2006cited by this paper
• Production and characterization of vaccines based on flaviviruses defective in replication.

  2006cited by this paper
• Sindbis Virus Nonstructural Protein nsP2 Is Cytotoxic and Inhibits Cellular Transcription

  2006influential reference
• Replication and Clearance of Venezuelan Equine Encephalitis Virus from the Brains of Animals Vaccinated with Chimeric SIN/VEE Viruses

  2006cited by this paper
• Thogoto virus ML protein suppresses IRF3 function.

  2005cited by this paper
• Transcriptional signaling by double-stranded RNA: role of TLR3.

  2005cited by this paper
• Noncytopathic Replication of Venezuelan Equine Encephalitis Virus and Eastern Equine Encephalitis Virus Replicons in Mammalian Cells

  2005influential reference
• Inhibition of Transcription and Translation in Sindbis Virus-Infected Cells

  2005influential reference
• Tetracycline-Inducible Packaging Cell Line for Production of Flavivirus Replicon Particles

  2004cited by this paper
• Analysis of Adaptive Mutations in Kunjin Virus Replicon RNA Reveals a Novel Role for the Flavivirus Nonstructural Protein NS2A in Inhibition of Beta Interferon Promoter-Driven Transcription

  2004cited by this paper
• NSs Protein of Rift Valley Fever Virus Blocks Interferon Production by Inhibiting Host Gene Transcription

  2004cited by this paper
• Targeting TFIIH to inhibit host cell transcription by Rift Valley Fever Virus.

  2004cited by this paper
• PKR-Dependent and -Independent Mechanisms Are Involved in Translational Shutoff during Sindbis Virus Infection

  2004cited by this paper
• TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus.

  2004cited by this paper
• Inhibition of interferon signaling by dengue virus

  2003cited by this paper
• The Ebola Virus VP35 Protein Inhibits Activation of Interferon Regulatory Factor 3

  2003cited by this paper
• Classical Swine Fever Virus Interferes with Cellular Antiviral Defense: Evidence for a Novel Function of Npro

  2003cited by this paper
• Classical swine fever virus interferes with cellular antiviral defense: evidence for a novel function of N(pro).

  2003cited by this paper
• Recombinant Sindbis/Venezuelan Equine Encephalitis Virus Is Highly Attenuated and Immunogenic

  2003cited by this paper
• The interaction of cytoplasmic RNA viruses with the nucleus.

  2003cited by this paper
• Roles of Nonstructural Protein nsP2 and Alpha/Beta Interferons in Determining the Outcome of Sindbis Virus Infection

  2002influential reference
• Evolutionary Relationships and Systematics of the Alphaviruses

  2001cited by this paper
• Genetic Evidence for an Interferon-Antagonistic Function of Rift Valley Fever Virus Nonstructural Protein NSs

  2001cited by this paper
• Inhibition of Host Transcription by Vesicular Stomatitis Virus Involves a Novel Mechanism That Is Independent of Phosphorylation of TATA-Binding Protein (TBP) or Association of TBP with TBP-Associated Factor Subunits

  2001cited by this paper
• Alphavirus Nucleocapsid Protein Contains a Putative Coiled Coil α-Helix Important for Core Assembly

  2001cited by this paper
• Influenza A Virus NS1 Protein Prevents Activation of NF-κB and Induction of Alpha/Beta Interferon

  2000cited by this paper
• Replicon Vectors Derived from Sindbis Virus and Semliki Forest Virus That Establish Persistent Replication in Host Cells

  2000cited by this paper
• The Ebola virus VP35 protein functions as a type I IFN antagonist.

  2000cited by this paper
• Selection of RNA Replicons Capable of Persistent Noncytopathic Replication in Mammalian Cells

  1999cited by this paper
• Inhibition of host RNA polymerase II-dependent transcription by vesicular stomatitis virus results from inactivation of TFIID.

  1998cited by this paper
• Sindbis virus replicons and Sindbis virus: assembly of chimeras and of particles deficient in virus RNA

  1997cited by this paper
• Packaging signals in alphaviruses

  1997cited by this paper
• Recombinational history and molecular evolution of western equine encephalomyelitis complex alphaviruses

  1997cited by this paper
• Translation of Sindbis virus mRNA: analysis of sequences downstream of the initiating AUG codon that enhance translation

  1996cited by this paper
• Translation of Sindbis virus mRNA: effects of sequences downstream of the initiating codon

  1994cited by this paper
• The alphaviruses: gene expression, replication, and evolution

  1994cited by this paper
• The Alphaviruses: Gene Expression, Replication, and Evolution

  1994cited by this paper
• A comparison of the nucleotide sequences of eastern and western equine encephalomyelitis viruses with those of other alphaviruses and related RNA viruses.

  1993cited by this paper
• Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs

  1993cited by this paper
• In vitro mutagenesis of a full-length cDNA clone of Semliki Forest virus: the small 6,000-molecular-weight membrane protein modulates virus release

  1991cited by this paper
• Complementation between Sindbis viral RNAs produces infectious particles with a bipartite genome.

  1991cited by this paper
• A New Generation of Animal Cell Expression Vectors Based on the Semliki Forest Virus Replicon

  1991cited by this paper
• Structure of Sindbis virus core protein reveals a chymotrypsin-like serine proteinase and the organization of the virion

  1991cited by this paper
• [Complete nucleotide sequence of the Eastern equine encephalomyelitis virus genome].

  1991cited by this paper
• Recombination between Sindbis virus RNAs

  1991cited by this paper
• Recombination between Sindbis virus RNAs.

  1991cited by this paper
• Complete sequence of the genomic RNA of O'nyong-nyong virus and its use in the construction of alphavirus phylogenetic trees.

  1990cited by this paper
• Mutations which alter the level or structure of nsP4 can affect the efficiency of Sindbis virus replication in a host-dependent manner

  1990cited by this paper
• The full-length nucleotide sequences of the virulent Trinidad donkey strain of Venezuelan equine encephalitis virus and its attenuated vaccine derivative, strain TC-83.

  1989cited by this paper
• Molecular basis of Sindbis virus neurovirulence in mice

  1988cited by this paper
• Western equine encephalitis virus is a recombinant virus.

  1988influential reference
• Production of infectious RNA transcripts from Sindbis virus cDNA clones: mapping of lethal mutations, rescue of a temperature-sensitive marker, and in vitro mutagenesis to generate defined mutants

  1987cited by this paper
• Complete nucleotide sequence of the nonstructural protein genes of Semliki Forest virus.

  1986cited by this paper
• Complete nucleotide sequence of the genomic RNA of Sindbis virus.

  1984cited by this paper
• Biochemical studies of the maturation of the small Sindbis virus glycoprotein E3.

  1984cited by this paper
• Nucleotide sequence of the 26S mRNA of Sindbis virus and deduced sequence of the encoded virus structural proteins.

  1981cited by this paper

• Multi-omics analysis of arboviral capsids targets in mosquitoes reveals a pro-viral function of the chromatin-remodeling Brahma complex.

  2026cites this paper
• The ability of alphavirus replicases to synthesize non-viral type I interferon-inducing RNAs correlates with viral RNA synthesis and has a diverse impact on virus replication and pathogenicity

  2026cites this paper
• Attenuation of Chikungunya Virus by a Single Amino Acid Substitution in the nsP1 Component of a Non-Structural Polyprotein

  2025cites this paper
• Viral interference of nucleocytoplasmic transport

  2025cites this paper
• ARRDC1 inhibits the replication of Semliki Forest virus by regulating the ubiquitination and degradation of viral nsP4

  2025cites this paper
• Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

  2025cites this paper
• Application of Pseudoinfectious Viruses in Transient Gene Expression in Mammalian Cells: Combining Efficient Expression with Regulatory Compliance

  2025cites this paper
• The Interplay Between Therapeutic Self-Amplifying RNA and the Innate Immune System: Balancing Efficiency and Reactogenicity

  2025cites this paper
• Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti‐Alphavirus Therapies

  2025cites this paper
• The advent of clinical self-amplifying RNA vaccines.

  2025cites this paper
• The pathogenicity and virulence of Sindbis virus

  2025cites this paper
• Functional RNA Elements in Alphavirus Genomes

  2025cites this paper
• Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2

  2024cites this paper
• Trans-amplifying RNA expressing functional miRNA mediates target gene suppression and simultaneous transgene expression

  2024cites this paper
• Venezuelan equine encephalitis virus non-structural protein 3 dictates superinfection exclusion in mammalian cells

  2024cites this paper
• Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons

  2024cites this paper
• Unraveling the complex interplay: immunopathology and immune evasion strategies of alphaviruses with emphasis on neurological implications

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• Translational Control of Alphavirus–Host Interactions: Implications in Viral Evolution, Tropism and Antiviral Response

  2024cites this paper
• Trans-amplifying RNA hitting new grounds: Gene regulation by microRNA

  2024cites this paper
• Increased viral tolerance mediates by antiviral RNA interference in bat cells.

  2024cites this paper
• Research trends on alphavirus receptors: a bibliometric analysis

  2024cites this paper
• Self-Replicating Alphaviruses: From Pathogens to Therapeutic Agents

  2024cites this paper
• Cellular takeover: How new world alphaviruses impact host organelle function.

  2024cites this paper
• Evaluation of bird-adapted self-amplifying mRNA vaccine formulations in chickens.

  2024cites this paper
• The sticky business of Alphavirus capsid-host interactions.

  2024cites this paper
• Alphaviral backbone of self-amplifying RNA enhances protein expression and immunogenicity against SARS-CoV-2 antigen

  2024cites this paper
• Exploring Barmah Forest virus pathogenesis: molecular tools to investigate non-structural protein 3 nuclear localization and viral genomic determinants of replication

  2024cites this paper
• Capsid protein mediated evasion of IRAK1-dependent signalling is essential to Sindbis virus neuroinvasion and virulence in mice

  2024cites this paper
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  2023cites this paper
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• Alphavirus-induced transcriptional and translational shutoffs play major roles in blocking the formation of stress granules

  2023cites this paper
• Alphavirus-based replicons demonstrate different interactions with host cells and can be optimized to increase protein expression

  2023influential citation
• Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8.

  2023cites this paper
• Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2

  2023cites this paper
• Checkpoint blockade meets gene therapy: Opportunities to improve response and reduce toxicity.

  2023cites this paper
• Transcriptome analysis of Huh7 cells upon Chikungunya virus infection and capsid transfection reveals regulation of distinct cellular and metabolic pathways.

  2023cites this paper
• Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons

  2023cites this paper
• Identification of mosquito proteins that differentially interact with alphavirus nonstructural protein 3, a determinant of vector specificity

  2023cites this paper
• All Domains of SARS-CoV-2 nsp1 Determine Translational Shutoff and Cytotoxicity of the Protein

  2023cites this paper
• The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Process for production of chimeric antigen receptor-transducing lentivirus particles using infection with replicon particles containing self-replicating RNAs

  2023cites this paper
• Self-inhibited State of Venezuelan Equine Encephalitis Virus (VEEV) nsP2 Cysteine Protease: A Crystallographic and Molecular Dynamics Analysis

  2023cites this paper
• Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses

  2022cites this paper
• High-Titer Self-Propagating Capsidless Chikungunya Virus Generated in Vero Cells as a Strategy for Alphavirus Vaccine Development

  2022cites this paper
• The life cycle of the alphaviruses: From an antiviral perspective.

  2022cites this paper
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  2022cites this paper
• Potassium viroporins as model systems for understanding eukaryotic ion channel behaviour.

  2022cites this paper
• Innate immune evasion by alphaviruses

  2022cites this paper
• Self-amplifying mRNA vaccines: mode of action, design, development and optimization.

  2022cites this paper
• Preparation and application of chikungunya pseudovirus containing double reporter genes

  2022cites this paper
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  2021cites this paper
• Genetically modified attenuated salmonid alphavirus: A potential strategy for immunization of Atlantic salmon.

  2021cites this paper
• Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA

  2021cites this paper
• The C-Terminal Domain of Salmonid Alphavirus Nonstructural Protein 2 (nsP2) Is Essential and Sufficient To Block RIG-I Pathway Induction and Interferon-Mediated Antiviral Response

  2021cites this paper
• Semliki Forest Virus Chimeras with Functional Replicase Modules from Related Alphaviruses Survive by Adaptive Mutations in Functionally Important Hot Spots

  2021cites this paper
• nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity

  2021cites this paper
• Alphaviruses: Host pathogenesis, immune response, and vaccine & treatment updates.

  2021cites this paper
• Arthritogenic Alphavirus Capsid Protein

  2021cites this paper
• Self-amplifying mRNA-Based Vaccine Technology and Its Mode of Action.

  2021cites this paper
• A Productive Expression Platform Derived from Host-Restricted Eilat Virus: Its Extensive Validation and Novel Strategy

  2021cites this paper
• Viral Vectors in Veterinary Vaccine Development: A Textbook

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Current and Promising Antivirals Against Chikungunya Virus

  2020cites this paper
• Infection of Mammals and Mosquitoes by Alphaviruses: Involvement of Cell Death

  2020cites this paper
• Protein Kinase C subtype δ interacts with Venezuelan equine encephalitis virus capsid protein and regulates viral RNA binding through modulation of capsid phosphorylation

  2020cites this paper
• A Low Fidelity Virus Shows Increased Recombination during the Removal of an Alphavirus Reporter Gene

  2020cites this paper
• Cross-utilisation of template RNAs by alphavirus replicases

  2020cites this paper
• Alphavirus Replication: The Role of Cardiac Glycosides and Ion Concentration in Host Cells

  2020cites this paper
• Quantitative proteomic analysis of chikungunya virus-infected Aedes aegypti reveals proteome modulations indicative of persistent infection.

  2020cites this paper
• Alphavirus capsid protease inhibitors as potential antiviral agents for Chikungunya infection.

  2020cites this paper
• Specificity Studies of the Venezuelan Equine Encephalitis Virus Non-Structural Protein 2 Protease Using Recombinant Fluorescent Substrates

  2020influential citation
• Production of Noncapped Genomic RNAs Is Critical to Sindbis Virus Disease and Pathogenicity

  2020cites this paper
• The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection

  2020cites this paper
• Hypervariable Domain of nsP3 of Eastern Equine Encephalitis Virus Is a Critical Determinant of Viral Virulence

  2020cites this paper
• Effect of exogenous expression of IFN-γ on the new world alphavirus replication and infection

  2019cites this paper
• Proteolytic cleavage of host proteins by the Group IV viral proteases of Venezuelan equine encephalitis virus and Zika virus

  2019cites this paper
• TF protein of Sindbis virus antagonizes host type I interferon responses in a palmitoylation-dependent manner

  2019cites this paper
• Current Understanding of the Molecular Basis of Venezuelan Equine Encephalitis Virus Pathogenesis and Vaccine Development

  2019cites this paper
• Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription

  2019cites this paper
• Molecular Virology of Chikungunya Virus.

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Viral helicase protein

  2019cites this paper
• Alphavirus-host interactions : how to unravel the proviral activity of G3BP

  2019cites this paper
• New World alphavirus protein interactomes from a therapeutic perspective.

  2019cites this paper
• Infectious Chikungunya Virus (CHIKV) with a Complete Capsid Deletion: a New Approach for a CHIKV Vaccine

  2019cites this paper
• RNA-Dependent RNA Polymerase of Alphaviruses

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
• Interactions of Alphavirus nsP3 Protein with Host Proteins

  2018influential citation
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  2018cites this paper
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  2018cites this paper
• The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies

  2018cites this paper
• Multiple Host Factors Interact with the Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode

  2018cites this paper