Efficacy and Safety of Tissue Plasminogen Activator 3 to 4.5 Hours After Acute Ischemic Stroke: A Metaanalysis

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Stroke

• Publication date

  2009-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/STROKEAHA.109.552547PMID 19478213PMCID PMC2725521
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.

  2008cited by this paper
• Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials.

  2004cited by this paper
• Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke.

  1999cited by this paper
• Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators.

  1998cited by this paper
• Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)

  1995cited by this paper
• Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.

  1995cited by this paper
• Tissue plasminogen activator for acute ischemic stroke.

  1995cited by this paper

• Quantifying the cost savings of the South Australian Telestroke Service.

  2026cites this paper
• Amniotic fluid stem cell-derived extracellular vesicles enhance functional recovery of neurogenic bladder and neurovascular plasticity after cerebral ischemia in rats.

  2026cites this paper
• Association of Original and Revised Pooled Cohort Equations With Cardiovascular and Cerebrovascular Mortality

  2026cites this paper
• Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke

  2025cites this paper
• Inhibition of diacylglycerol O-acyltransferase 1 provides neuroprotection by inhibiting ferroptosis in ischemic stroke

  2025cites this paper
• Quercetin-loaded zeolitic imidazolate framework-8 nanoparticles through borneol-embedded hyaluronic acid hydrogel for ischemic stroke treatment.

  2025cites this paper
• Factors affecting the early efficacy of intravenous thrombolysis using alteplase in acute ischemic stroke: A retrospective analysis of 255 cases

  2025cites this paper
• GLP-1 Receptor Agonists as Treatment of Nondiabetic Ischemic Stroke-A Systematic Review and Meta-Analysis.

  2025cites this paper
• Use of alteplase continuous rate infusion, pentoxifylline, and cyproheptadine in association or not, in acute feline aortic thromboembolism: a study of nine cats

  2025cites this paper
• Magnetically powered microwheel thrombolysis of occlusive thrombi in zebrafish

  2024cites this paper
• Impact of the COVID-19 pandemic on acute cardiology and neurology services in a secondary peripheral hospital

  2024cites this paper
• Mechanisms by Which Electroacupuncture Alleviates Neurovascular Unit Injury after Ischemic Stroke: A Potential Therapeutic Strategy for Ischemic Brain Injury after Stroke.

  2024cites this paper
• Simple and Swift Acute Ischemic Stroke Therapy based on Cases and Evidence: Possibilities of Cost Reduction and Improving Global Access

  2023cites this paper
• Scutellarin Alleviates Ischemic Brain Injury in the Acute Phase by Affecting the Activity of Neurotransmitters in Neurons

  2023cites this paper
• Transferring Patients From a Primary Stroke Center to Higher Levels of Care: A Qualitative Study of Stroke Coordinators’ Experiences

  2023cites this paper
• Effect of Alteplase on Ischemic Stroke Mortality Is Dependent on Stroke Severity

  2023cites this paper
• In-hospital treatment outcomes of acute stroke and determinant factors in a teaching hospital in eastern Ethiopia

  2023cites this paper
• Understanding cost effectiveness in neurology.

  2023cites this paper
• Immunologic Implications for Stroke Recovery: Unveiling the Role of the Immune System in Pathogenesis, Neurorepair, and Rehabilitation

  2023cites this paper
• Magnetically Powered Microwheel Thrombolysis of Occlusive Thrombi in Zebrafish

  2023cites this paper
• A modified murine photothrombotic stroke model: a minimally invasive and reproducible cortical and sub-cortical infarct volume and long-term deficits

  2023cites this paper
• Development of a flexible self-calculation scoring model to determine stroke occurrence

  2023cites this paper
• Sirtuins and cognition: implications for learning and memory in neurological disorders

  2022cites this paper
• Network pharmacology approach to investigate the multitarget mechanisms of Zhishi Rhubarb Soup on acute cerebral infarction

  2022cites this paper
• The potential role of insulin resistance in predicting outcome from intravenous thrombolytic therapy

  2022cites this paper
• Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion

  2022cites this paper
• Nonhuman Primate Models of Ischemic Stroke and Neurological Evaluation After Stroke.

  2022cites this paper
• Sex differences in thrombosis as it affects acute ischemic stroke.

  2022cites this paper
• Neuroprotective Mechanisms of Glucagon-Like Peptide-1-Based Therapies in Ischemic Stroke: An Update Based on Preclinical Research

  2022cites this paper
• Establishment of a Modified and Standardized Ferric Chloride-Induced Rat Carotid Artery Thrombosis Model

  2022cites this paper
• Letter to the Editor Regarding CADTH rapid review: Systemic Thrombolysis by Alteplase for Acute Ischemic Stroke

  2022cites this paper
• Induced pluripotent stem cells can improve thrombolytic effect of low-dose rt-PA after acute carotid thrombosis in rat

  2021cites this paper
• Synergic Neuroprotection Between Ligusticum Chuanxiong Hort and Borneol Against Ischemic Stroke by Neurogenesis via Modulating Reactive Astrogliosis and Maintaining the Blood–Brain Barrier

  2021cites this paper
• Use of evidence in acute stroke decision-making: Implications for evidence-based medicine.

  2021cites this paper
• Novel Insights into the Potential Diagnostic Value of Circulating Exosomal IncRNA-Related Networks in Large Artery Atherosclerotic Stroke

  2021cites this paper
• Effect of opposing needling on motor cortex excitability in healthy participants and in patients with post-stroke hemiplegia: study protocol for a single-blind, randomised controlled trial

  2021cites this paper
• Intranasal Administration of PACAP Is an Efficient Delivery Route to Reduce Infarct Volume and Promote Functional Recovery After Transient and Permanent Middle Cerebral Artery Occlusion

  2021cites this paper
• Drug Delivery Challenges in Brain Disorders across the Blood–Brain Barrier: Novel Methods and Future Considerations for Improved Therapy

  2021cites this paper
• Investigation of convolutional neural networks using multiple computed tomography perfusion maps to identify infarct core in acute ischemic stroke patients

  2021cites this paper
• Thrombolysis: Observations and numerical models.

  2021cites this paper
• Neurological Critical Care: The Evolution of Cerebrovascular Critical Care.

  2021cites this paper
• A Clinical Observation of Intravenous Thrombolysis in Acute Ischemic Stroke with Minor Trauma

  2021cites this paper
• Short- and long-term mortality after intravenous thrombolysis for acute ischemic stroke

  2021cites this paper
• Human amniotic fluid stem cells can improve cerebral vascular remodelling and neurological function after focal cerebral ischaemia in diabetic rats

  2021cites this paper
• The proteomics analysis of the effects of Zhishi Rhubarb soup on ischaemic stroke

  2021cites this paper
• Neuroprotection Following Stroke

  2021cites this paper
• Improved collateral flow and reduced damage after remote ischemic perconditioning during distal middle cerebral artery occlusion in aged rats

  2020cites this paper
• Time to Wake-Up: Extending the Window for Management of Unknown-Onset Strokes

  2020cites this paper
• Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: the first multicentre, phase III trial in China

  2020cites this paper
• Post-stroke patients with and without thrombolysis: analysis of deglutition in the acute phase of the disease.

  2020cites this paper
• iTRAQ-based proteomic analysis after mesenchymal stem cell line transplantation for ischemic stroke.

  2020cites this paper
• Stroke following successful PTMC in a patient with severe mitral stenosis: A case report and presenting a simple stepwise approach to PTMC-related stroke.

  2020cites this paper
• A Mouse Brain-based Multi-omics Integrative Approach Reveals Potential Blood Biomarkers for Ischemic Stroke

  2020cites this paper
• Preconditioning Strategies to Enhance Neural Stem Cell-Based Therapy for Ischemic Stroke

  2020cites this paper
• Mobile App Based Strategy Improves Door-to-Needle Time in the Treatment of Acute Ischemic Stroke.

  2020cites this paper
• Timely Administration of Thrombolytic Therapy in Acute Ischemic Stroke: An Ethnographic Study

  2020cites this paper
• Outcome predictors of intravenous thrombolytic therapy in acute ischemic stroke patients: an Egyptian center experiences

  2020cites this paper
• Resveratrol Preconditioning Induces Bioenergetic Efficiency in the Brain within the Long-Term Window of Cerebral Ischemic Tolerance

  2019cites this paper
• UNIVERSITY OF MIAMI RESVERATROL PRECONDITIONING INDUCES BIOENERGETIC EFFICIENCY IN THE BRAIN WITHIN THE LONG-TERM WINDOW OF CEREBRAL ISCHEMIC TOLERANCE By

  2019cites this paper
• Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels.

  2019cites this paper
• A Case Report of Korean Medicine Treatment for Acute Cerebral Infarction with Cerebral Hemorrhage

  2019cites this paper
• Combined proteomic and metabolomic analyses of cerebrospinal fluid from mice with ischemic stroke reveals the effects of a Buyang Huanwu decoction in neurodegenerative disease

  2019cites this paper
• N2 neutrophils may participate in spontaneous recovery after transient cerebral ischemia by inhibiting ischemic neuron injury in rats.

  2019cites this paper
• Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective

  2019cites this paper
• The 5α-Reductase Inhibitor Finasteride Exerts Neuroprotection Against Ischemic Brain Injury in Aged Male Rats

  2019cites this paper
• Administration of troxerutin and cerebroprotein hydrolysate injection alleviates cerebral ischemia/reperfusion injury by down-regulating caspase molecules

  2019cites this paper
• Aptamer von Willebrand Factor Inhibition in Small and Large Stroke Models

  2019cites this paper
• Polyacrylic acid-coated nanoparticles loaded with recombinant tissue plasminogen activator for the treatment of mice with ischemic stroke.

  2019cites this paper
• Cerebrovascular Disease and Disorders

  2019cites this paper
• Intravenous Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients With History of Stroke Plus Diabetes Mellitus.

  2019cites this paper
• Level of motor, sensory and functional impairment from stroke at admission and hospital discharge in Brazil

  2019cites this paper
• Using Dental Pulp Stem Cells for Stroke Therapy

  2019cites this paper
• Juxtaposition of One and a Half Syndrome with Pseudo One and a Half Syndrome

  2018cites this paper
• Therapeutic Window Beyond Cerebral Ischemic Reperfusion Injury

  2018cites this paper
• Development of a Longitudinal Imaging System for Murine Brain Injury Models

  2018cites this paper
• Clinical application of susceptibility-weighted imaging in the evaluation of leptomeningeal collateralization

  2018cites this paper
• Resveratrol Preconditioning Induces Genomic and Metabolic Adaptations within the Long-Term Window of Cerebral Ischemic Tolerance Leading to Bioenergetic Efficiency

  2018cites this paper
• Integrated Histotripsy and Bubble Coalescence Transducer for Thrombolysis.

  2018cites this paper
• Identification and functional analysis of differentially expressed genes associated with cerebral ischemia/reperfusion injury through bioinformatics methods

  2018cites this paper
• Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury.

  2018cites this paper
• Long-Term Survival After Intravenous Thrombolysis for Ischemic Stroke

  2018cites this paper
• Long-Term Survival After Intravenous Thrombolysis for Ischemic Stroke A Propensity Score-Matched Cohort With up to 10-Year Follow-Up

  2018cites this paper
• Stroke Therapy Development Successes: Research Guidelines and Embolic Stroke Models for Monotherapy and Adjuvant Therapy Development

  2017cites this paper
• Cytoprotective Drug-Tissue Plasminogen Activator Protease Interaction Assays: Screening of Two Novel Cytoprotective Chromones

  2017cites this paper
• Reflections on Neuroprotection Research and the Path Toward Clinical Success

  2017cites this paper
• Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke

  2017cites this paper
• Acute Ischemic Stroke 2 adopt the function of neural tissue destroyed by ischemia

  2017influential citation
• Human Umbilical Cord Mesenchymal Stem Cells Preserve Adult Newborn Neurons and Reduce Neurological Injury after Cerebral Ischemia by Reducing the Number of Hypertrophic Microglia/Macrophages

  2017cites this paper
• Delayed administration of the GLP-1 receptor agonist liraglutide improves metabolic and functional recovery after cerebral ischemia in rats.

  2017cites this paper
• Adaptive Plasticity After Focal Ischemic Stroke

  2017influential citation
• Acute connexin43 temporal and spatial expression in response to ischemic stroke

  2017cites this paper
• One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke

  2017cites this paper
• The NAD+-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning

  2017cites this paper
• Bladder Transplantation of Amniotic Fluid Stem Cell may Ameliorate Bladder Dysfunction After Focal Cerebral Ischemia in Rat

  2017cites this paper
• Excitatory and inhibitory amino acid neurotransmitters in stroke: from neurotoxicity to ischemic tolerance

  2017cites this paper
• Acute cerebral infarction following aconitine ingestion

  2017cites this paper
• Therapies for Hemorrhagic Transformation in Acute Ischemic Stroke

  2017cites this paper
• Electroacupuncture-induced neuroprotection against focal cerebral ischemia in the rat is mediated by adenosine A1 receptors

  2017cites this paper
• Identifikation großer zerebraler Infarktvolumen in der diffusionsgewichteten MRT mittels zweier orthogonaler Durchmesser

  2016cites this paper
• Targeting ONOO-/HMGB1/MMP-9 Signaling Cascades: Potential for Drug Development from Chinese Medicine to Attenuate Ischemic Brain Injury and Hemorrhagic Transformation Induced by Thrombolytic Treatment

  2016cites this paper