Neuroprotective Effects of Low-Intensity Pulsed Ultrasound in Chronic Traumatic Encephalopathy Induced by Repetitive Head Collisions: A Narrative Review

Min Zhang,Liang Zhao,Paulo Cesar Lock Silveira

Published 2025 in Biology

ABSTRACT

Simple Summary Sports collisions significantly contribute to the increase in neurodegenerative diseases. Chronic traumatic encephalopathy (CTE) is one of the common neurodegenerative conditions athletes often face in contact sports, with no cure, because the symptoms are similar to other conditions like AD and PD. Early diagnosis can be difficult, which may cause the condition to worsen. Additionally, this can affect participants’ quality of life and public health in various ways, including an increased risk of injuries and the cost linked to treatment, mental health, and long-term health consequences. Therefore, this review aims to highlight the possible molecular targets that can be regulated during the application of low-intensity pulsed ultrasound (LIPUS) for improving CTE.

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