Prognostic Significance of WWOX/HIF1A Ratio in Cancer Subtypes: Insights into Metabolism, ECM, and EMT

Simple Summary WWOX is a gene that plays a key role in regulating cellular processes related to maintaining homeostasis and protecting against cancer, through interactions with many proteins and signalling pathways. One of the important partners of WWOX is the hypoxia inducible factor HIF1α. Through this interaction, WWOX modulates cancer cell metabolism, which serves as an important prognostic factor. This study assessed the prognostic significance of the WWOX/HIF1A ratio in various cancers: breast cancer subtypes, glioblastoma multiforme, low-grade glioma, and hepatocellular carcinoma. It was found that in breast cancer, the WWOX/HIF1A ratio allows for the identification of groups of patients with favourable and unfavourable prognosis—in basal and HER2 breast cancer subtypes, high WWOX/HIF1A was associated with a more favourable prognosis, whereas in luminal A and B subtypes, it correlated with a less favourable prognosis. In the remaining analysed cancers, a higher WWOX/HIF1A expression ratio also allowed for determining the prognosis; in brain tumours and hepatocellular carcinoma, it clearly correlated with better survival. In conclusion, the WWOX/HIF1A expression ratio might be considered as a potential biomarker determining the prognosis of cancer patients.

• Publication year

  2025

• Venue

  Biology

• Publication date

  2025-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/biology14091151PMID 41007296PMCID 12467568
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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