Targeting immunosenescence and inflammaging: advancing longevity research

Here we examine the crucial role of the immune system in aging, with a particular focus on two interconnected processes: immunosenescence and inflammaging, which contribute to age-related decline. Our goal is to provide a thorough overview of the various factors that lead to immune aging while introducing therapeutic approaches that can partially restore immune function. Additionally, we discuss recent strategies that go beyond localized immune improvement to actively modulate immune balance, influencing systemic aging and extending healthspan. Through this exploration, we propose that regulating the immune system is essential for managing immune aging and may serve as a key mechanism for controlling the overall aging process and promoting healthy longevity. Aging affects our immune system, leading to a decline in its function and increased inflammation, known as immunosenescence and inflammaging. Researchers have studied ways to improve immune health and extend lifespan. It reviews various strategies to combat immune aging, such as rejuvenating the thymus, enhancing stem cell function and using therapies to clear senescent cells. These approaches aim to restore immune balance and reduce chronic inflammation. It highlights the importance of targeting specific pathways, such as IL-11 and TLR5, to improve immune resilience and promote healthy aging. The findings suggest that by addressing both immune decline and chronic inflammation, we can potentially extend lifespan and improve health in older adults. Future research will focus on refining these strategies for clinical use, offering hope for healthier aging. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.

• Publication year

  2025

• Venue

  Experimental and Molecular Medicine

• Publication date

  2025-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/s12276-025-01527-9PMID 40887496PMCID 12508447
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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