CYP11B2 expression in HSCs and its effect on hepatic fibrogenesis.

It has been reported that renin-angiotensin system exists in tissue[1] and aldosterone can be synthesized in extra-adrenal tissue including heart, blood vessels[2] and brain[3]. Recent studies have brought rich evidences in favour of aldosterone as a strong stimulator of fibrogenesis and mitogenesis[4-9]. Recently Wu PS reported that aldosterone synthase gene CYP11B2 can be expressed in hepatic stellate cells (HSCs) of liver[10]. As the activation of HSCs is the central event in fibrogenesis of liver[11-26], we undertook the present study to investigate the relationship between hepatic fibrogenesis and locally produced aldosterone in liver.

• Publication year

  2000

• Venue

  World Journal of Gastroenterology

• Publication date

  2000-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3748/WJG.V6.I6.885PMID 11819714PMCID PMC4728280
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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