The effect of retinoic acid on Ito cell proliferation and content of DNA and RNA.

The development of liver fibrosis is due to an imbalance between synthesis and degradation of extracellular matrix. Recent studies have shown that Ito cells which are located along the sinuses of liver, can store and metabolize Vit A, and are the main cells that produce collagen, among which type I, III and IV and laminin, account for 80%-95% of the total hepatic collagen[1]. Ito cells in the course of proliferation and synthesis of collagen showed a reduction of Vit A contents and retinoic acid receptors[2]. This study was designed to investigate the effect of retinoic acid on Ito cell proliferation and the contents of DNA/RNA and to analyse further its mechanism or pathways.

• Publication year

  1999

• Venue

  World Journal of Gastroenterology

• Publication date

  1999-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3748/WJG.V5.I5.443PMID 11819486PMCID PMC4688618
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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