SCIENCE@home

Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses

Amy Moore,E. Kane,L. Teras,M. Machiela,Joshua Arias,O. Panagiotou,A. Monnereau,N. W. Doo,Zhaoming Wang,S. Slager,R. C. Vermeulen,C. Vajdic,K. Smedby,J. Spinelli,J. Vijai,Graham G. Giles,B. Link,A. Arslan,Alexandra Nieters,P. Bracci,Nicola J. Camp,G. Salles,W. Cozen,H. Hjalgrim,I. De Vivo,Hans-Olov Adami,D. Albanes,Nikolaus Becker,Y. Benavente,S. Bisanzi,Paolo Boffetta,Paul Brennan,A. Brooks-Wilson,F. Canzian,Jacqueline Clavel,L. Conde,David G. Cox,Karen Curtin,L. Foretova,Hervé Ghesquières,Bengt Glimelius,T. Habermann,Jonathan N. Hofmann,Qing Lan,M. Liebow,Anne Lincoln,M. Maynadié,J. McKay,M. Melbye,L. Miligi,R. Milne,T. J. Molina,Lindsay M. Morton,Kari E. North,K. Offit,M. Padoan,S. Piro,Alpa V. Patel,M. Purdue,Vignesh Ravichandran,E. Riboli,R. Severson,M. Southey,A. Staines,L. Tinker,R. Travis,Sophia S. Wang,E. Weiderpass,S. Weinstein,Tongzhang Zheng,S. Chanock,Nathaniel Rothman,B. Birmann,J. Cerhan,Sonja I. Berndt

Published 2025 in International Journal of Cancer

ABSTRACT

Obesity has been associated with non‐Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B‐cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome‐wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist‐to‐hip ratio (WHR), and waist‐to‐hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05–1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (ORper SD = 1.12, 95% CI: 1.02–1.23, p = .03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-62 of 62 references · Page 1 of 1

CITED BY