Recent Progress in Nonanolides of Natural Origin: Structures, Synthesis, Biosynthesis, and Bioactivities.

Nonanolides, a diverse group of secondary metabolites with a unique 10-membered lactone subunit, are abundant in nature. To date, nonanolides have exhibited various biological activities, including cytotoxicity, phytotoxicity, antimalarial activity, antiosteoporosis, and antimicrobial activity. Previous literature has extensively reviewed nonanolides reported from 1975 to July 2011. In the past decade alone, numerous novel nonanolides with intricate structures and remarkable biological activities have been continuously documented. This review provides an overview of naturally occurring nonanolides reported from August 2011 to August 2024, encompassing their occurrence in nature, structural classifications, synthetic strategies, biosynthesis, and biological activities.

• Publication year

  2025

• Venue

  The chemical record

• Publication date

  2025-09-04

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/tcr.202500123PMID 40908779
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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