The p53–Bcl-2 connection

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cell Death and Differentiation

• Publication date

  2006-05-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.cdd.4401962PMID 16710363PMCID PMC4590992
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• WT p53, but Not Tumor-derived Mutants, Bind to Bcl2 via the DNA Binding Domain and Induce Mitochondrial Permeabilization*

  2006cited by this paper
• Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

  2005cited by this paper
• Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM

  2005cited by this paper
• Life in the balance: how BH3-only proteins induce apoptosis.

  2005cited by this paper
• Mitochondrially targeted p53 has tumor suppressor activities in vivo.

  2005cited by this paper
• Transcription-independent pro-apoptotic functions of p53.

  2005cited by this paper
• PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53

  2005cited by this paper
• Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

  2005cited by this paper
• Stress-induced p53 runs a transcription-independent death program.

  2005cited by this paper
• Defining the p53 DNA‐binding domain/Bcl‐xL‐binding interface using NMR

  2004cited by this paper
• Suppression of tumorigenesis by the p53 target PUMA.

  2004cited by this paper
• Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

  2004cited by this paper
• Bim is a suppressor of Myc-induced mouse B cell leukemia.

  2004cited by this paper
• Intrinsic tumour suppression

  2004cited by this paper
• p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

  2003cited by this paper
• The Bcl-2 family: roles in cell survival and oncogenesis

  2003cited by this paper
• Puma is an essential mediator of p53-dependent and -independent apoptotic pathways.

  2003cited by this paper
• Apoptosis in the development and maintenance of the immune system

  2003cited by this paper
• PUMA mediates the apoptotic response to p53 in colorectal cancer cells

  2003cited by this paper
• Integral role of Noxa in p53-mediated apoptotic response.

  2003cited by this paper
• Dissecting p53 tumor suppressor functions in vivo.

  2002cited by this paper
• A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.

  2002cited by this paper
• BID regulation by p53 contributes to chemosensitivity

  2002cited by this paper
• Apoptosis regulators and their role in tumorigenesis.

  2001cited by this paper
• PUMA, a novel proapoptotic gene, is induced by p53.

  2001cited by this paper
• Mutations of the bak gene in human gastric and colorectal cancers.

  2000cited by this paper
• Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.

  2000cited by this paper
• A transactivation-deficient mouse model provides insights into Trp53 regulation and function

  2000cited by this paper
• Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo

  1999cited by this paper
• Activation of p53 by oncogenes.

  1999cited by this paper
• INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

  1999cited by this paper
• Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle Arrest

  1998cited by this paper
• Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.

  1998cited by this paper
• Induction of BCL2 family member MCL1 as an early response to DNA damage

  1997cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

  1997cited by this paper
• bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis.

  1997cited by this paper
• Bax suppresses tumorigenesis and stimulates apoptosis in vivo

  1997cited by this paper
• Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

  1997cited by this paper
• Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

  1996cited by this paper
• p53: puzzle and paradigm.

  1996cited by this paper
• Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene‐mediated apoptosis.

  1996cited by this paper
• Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

  1995cited by this paper
• A novel form of Epstein-Barr virus latency in normal B cells in vivo.

  1995cited by this paper
• Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.

  1995cited by this paper
• Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

  1995cited by this paper
• Identification of a p53-dependent negative response element in the bcl-2 gene.

  1994cited by this paper
• Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

  1994cited by this paper
• Mediation of c-Myc-induced apoptosis by p53.

  1994cited by this paper
• Down-regulation of bcl-2 by p53 in breast cancer cells.

  1994cited by this paper
• p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

  1994cited by this paper
• p53-dependent apoptosis suppresses tumor growth and progression in vivo.

  1994cited by this paper
• Thymocyte apoptosis induced by p53-dependent and independent pathways

  1993cited by this paper
• p53 is required for radiation-induced apoptosis in mouse thymocytes

  1993cited by this paper
• Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

  1993cited by this paper
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

  1993cited by this paper
• Bcl-2 initiates a new category of oncogenes: regulators of cell death.

  1992cited by this paper
• A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.

  1992cited by this paper
• Induction of apoptosis in fibroblasts by c-myc protein.

  1992cited by this paper
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

  1992cited by this paper
• Participation of p53 protein in the cellular response to DNA damage.

  1991cited by this paper
• Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

  1991cited by this paper
• Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

  1991cited by this paper
• Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

  1985cited by this paper
• Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

  1985cited by this paper
• The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.

  1985cited by this paper
• Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

  1984cited by this paper
• Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

  1984cited by this paper
• Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

  1984cited by this paper
• T antigen is bound to a host protein in SY40-transformed cells

  1979cited by this paper
• Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells.

  1979cited by this paper

• Involvement of Keap1/Nrf2 and the antioxidant defence in cytoprotective effects induced by cannabis polyphenols in SH-SY5Y neuronal cells.

  2026cites this paper
• The Interaction of Structural Analogues of Phenothiazines in p53-Dependent Cellular Signaling Pathways

  2026cites this paper
• Exploring pyrazoline-thiophene hybrids as CDK2 inhibitors: synthesis, mechanism, biological studies, and computational insights.

  2026cites this paper
• Dynamics of bcl-2-positive lymphocytes in different zones of white pulp of rat spleen after soft tissue injury of thigh: morphometric analysis

  2026cites this paper
• Lippia citriodora Essential Oils Induce Cytotoxicity and Modify Transcription Levels of Bcl-2 , Bax , p53 , and c-Jun Genes in Breast Cancer Cells

  2026cites this paper
• Spatially Resolved Metabolomics and Network Pharmacology Reveal Extract D Nephrotoxicity Mechanisms in Pleuropterus multiflorus Thunb.

  2025cites this paper
• Downregulation of DDIT4 levels with borneol attenuates hepatotoxicity induced by gilteritinib.

  2025cites this paper
• Regulatory Interplay of p53, AMPK, and mTOR in Decidualization: Implications for Reproductive Competence and Cancer Biology

  2025cites this paper
• Effect of bioactive peptides on heat stress-induced testiculopathies in mature rats: immunohistopathological evidence

  2025cites this paper
• Mimicking Cell‐Death Process of Vertebrates Using Analog Electronics Circuit

  2025cites this paper
• Green tea enriched with catechins prevents particulate matter2.5 exposure-induced cardiovascular cytotoxicity via regulation of ferroptosis in BALB/c mice

  2025cites this paper
• Synthesis and Evaluation of Novel Bis-Chalcone Derivatives Containing a Thiophene Moiety as Potential Anticancer Agents: In Vitro, In Silico , and Mechanistic Studies

  2025cites this paper
• iModEst: disentangling -omic impacts on gene expression variation across genes and tissues

  2025cites this paper
• Unraveling the role of deubiquitinating enzymes on cisplatin resistance in several cancers.

  2025cites this paper
• IMMUNOHISTOCHEMICAL VERIFICATION OF P53 AND BCL-2 EXPRESSION IN RAT LIVER HEPATOCYTES AFTER MECHANICAL THIGH INJURY

  2025cites this paper
• Mechanotransduction-related ferroptosis: Enhancing boron neutron capture therapy efficacy in glioblastoma using a spheroid model

  2025cites this paper
• Glycyrrhetinic acid ameliorates gastric mucosal injury by modulating gut microbiota and its metabolites via Thbs1/PI3K-Akt/p53 pathway.

  2025cites this paper
• The synergy of TPL and selinexor in MLL-R acute myeloid leukemia via Rap1/Raf/MEK pathway-mediated MYC downregulation

  2025cites this paper
• Caspase-independent cell death in lung cancer: from mechanisms to clinical applications

  2025cites this paper
• Screening of Bioactive Fractions from Balanites aegyptiaca and Pterocarpus Marsupium for Anticancer Effects in HepG2 and U87MG Cels.

  2025cites this paper
• Linoleic Acid Potentiates Response to Chemotherapy in Biliary Tract Cancer Through RARγ Activation

  2025cites this paper
• Enhanced pro-apoptotic and pro-oxidative effects of hesperidin on LNCaP prostate cancer cell line through nano-emulsification

  2025cites this paper
• Diosmin induces mitochondrial-mediated apoptosis and anti-inflammatory effects in Hep-2 cells: an integrated in vitro and in silico analysis

  2025cites this paper
• Buxus natalensis (Oliv.) Hutch (Buxaceae) Exhibits Its Anticancer Potential by Stimulating ROS Production and Caspase-p53-BCL-2-Dependent Apoptosis in Hepatocellular Carcinoma and Prostate Cancer Cell Lines

  2025cites this paper
• Acrylamide Induces Antiapoptotic Autophagy and Apoptosis by Activating PERK Pathway in SH-SY5Y Cells

  2025cites this paper
• MIS18BP1 promotes bladder cancer cell proliferation and growth via inactivating P53 signaling pathway

  2025cites this paper
• Exploring the therapeutic role of carnosol in cancer: from molecular insights to clinical promise

  2025cites this paper
• Investigating the expression changes of several key genes in prostate cancer cells under exposure to the ELF pulsed electromagnetic fields

  2025influential citation
• MicroRNA regulation in neural tube defects: Insights into pathogenesis and potential therapeutic targets.

  2025cites this paper
• Exploration of the anticancer properties of Caffeic Acid in malignant mesothelioma cells

  2025cites this paper
• Evaluation of Lactobacillus delbrueckii Supernatant Effects on Cell Cycle Regulation, Apoptosis Induction, and Gene Expression in HT-29 Colorectal Cancer Cells

  2025cites this paper
• Dynamical analysis of a model of BCL-2-dependent cellular decision making

  2025cites this paper
• Dual intervention of Boeravinone B and Chebulinic Acid mitigates BHT-Induced toxicity in HepG2 cells: modulating apoptosis and autophagy

  2024cites this paper
• Novel Spirooxindole–Benzofuran Scaffold: Potential Inhibition Against Hepatocellular Carcinoma by Targeting MDM2‐p53 Interaction

  2024cites this paper
• Therapeutic targeting of senescent cells in the CNS

  2024cites this paper
• The Association of TP53, BCL2, BAX and NOXA SNPs and Laryngeal Squamous Cell Carcinoma Development

  2024cites this paper
• Nobiletin enhances mitochondrial function by regulating SIRT1/PGC-1α signaling in porcine oocytes during in vitro maturation.

  2024cites this paper
• Evaluation of the Efficacy of Diosmin and Chrysin against Tau-fluvalinate Exposure in Rats.

  2024cites this paper
• Is autism a PIN1 deficiency syndrome? A proposed etiological role for glyphosate

  2024cites this paper
• Antioxidant Defenses, Oxidative Stress Responses, and Apoptosis Modulation in Spontaneous Abortion: An Immunohistochemistry Analysis of First-Trimester Chorionic Villi

  2024cites this paper
• Comprehensive review of Bcl‐2 family proteins in cancer apoptosis: Therapeutic strategies and promising updates of natural bioactive compounds and small molecules

  2024cites this paper
• Cymensifin A: a promising pharmaceutical candidate to defeat lung cancer via cellular reactive oxygen species-mediated apoptosis

  2024cites this paper
• Exposure to microplastics renders immunity of the thick-shell mussel more vulnerable to diarrhetic shellfish toxin-producing harmful algae.

  2024cites this paper
• Targeting the p90RSK/MDM2/p53 Pathway Is Effective in Blocking Tumors with Oncogenic Up-Regulation of the MAPK Pathway Such as Melanoma and Lung Cancer

  2024cites this paper
• Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia

  2024cites this paper
• UDCA for Drug-Induced Liver Disease: Clinical and Pathophysiological Basis

  2024cites this paper
• Enhancing apoptosis-mediated anticancer activity of evodiamine through protein-based nanoparticles in breast cancer cells

  2024cites this paper
• Determination of dose- and time-dependent hepatotoxicity and apoptosis of Lanthanum oxide nanoparticles in female Swiss albino mice

  2024cites this paper
• Clusterin: a double-edged sword in cancer and neurological disorders

  2024cites this paper
• Increased cancer risk in HIV-infected individuals occupationally exposed to chemicals: Depression of p53 as the key driver

  2024cites this paper
• Propanil impairs organ development in zebrafish by inducing apoptosis and inhibiting mitochondrial respiration.

  2024cites this paper
• Antitumor activity of α‐pinene in T‐cell tumors

  2024cites this paper
• Innovative microwave-assisted biosynthesis of copper oxide nanoparticles loaded with platinum(ii) based complex for halting colon cancer: cellular, molecular, and computational investigations

  2024cites this paper
• Omega 3 fatty acids preserve testicular function by ameliorating BPF-induced dysthyroidism: role of p53/Bcl-2 signaling and proton pump activities

  2024cites this paper
• Insight into the molecular mechanism of anti-breast cancer therapeutic potential of substituted salicylidene-based compounds using cell-based assays and molecular docking studies.

  2024cites this paper
• Integrating network pharmacology and experimental validation to investigate the effects and mechanism of Renshen Shouwu decoction for ameliorating Alzheimer’s disease

  2024cites this paper
• 2,2-Diphenethyl Isothiocyanate Enhances Topoisomerase Inhibitor-Induced Cell Death and Suppresses Multi-Drug Resistance 1 in Breast Cancer Cells

  2023cites this paper
• Anticancer Mechanism of Flavonoids on High-Grade Adult-Type Diffuse Gliomas

  2023cites this paper
• Aluminium bioaccumulation in colon cancer, impinging on epithelial-mesenchymal-transition and cell death.

  2023cites this paper
• Time-dependent unloading effects on muscle and bone and involvement of FNDC5/irisin axis

  2023cites this paper
• CopA3 peptide inhibits MDM2-p53 complex stability in colorectal cancers and activates p53 mediated cell death machinery.

  2023cites this paper
• The CNS-penetrating taxane drug TPI 287 potentiates antiglioma activity of the AURKA inhibitor alisertib in vivo

  2023cites this paper
• Feeding Lycium barbarum polysaccharides (LBP) alleviates apoptotic, inflammatory hepatopancreas atrophy and injury in Chinese mitten crab (Eriocheir sinensis) poisoned by T-2 toxin

  2023cites this paper
• Co-encapsulation of hydrophilic and hydrophobic drugs into niosomal nanocarrier for enhanced breast cancer therapy: In silico, and in vitro studies.

  2023cites this paper
• Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study

  2023cites this paper
• Elevated level of PLRG1 is critical for the proliferation and maintenance of genome stability of tumor cells

  2023cites this paper
• Recent advances of bioactive proteins/polypeptides in the treatment of breast cancer

  2023cites this paper
• Translating the Biology of Aging into New Therapeutics for Alzheimer’s Disease: Senolytics

  2023influential citation
• Molecular Mechanisms and the Interplay of Important Chronic Obstructive Pulmonary Disease Biomarkers Reveals Novel Therapeutic Targets

  2023cites this paper
• Preparation and physicochemical properties of cisplatin and doxorubicin encapsulated by niosome alginate nanocarrier for cancer therapy.

  2023cites this paper
• The Role of Aloe vera in Inhibiting the P53 Protein Expression and Enhancing the HT29 Colon Cancer Cells Proliferation

  2023cites this paper
• Combination of Zearalenone and Deoxynivalenol Induces Apoptosis by Mitochondrial Pathway in Piglet Sertoli Cells: Role of Endoplasmic Reticulum Stress

  2023cites this paper
• Urolithin B inhibits proliferation and migration and promotes apoptosis and necrosis by inducing G2/M arrest and targeting MMP‐2/‐9 expression in osteosarcoma cells

  2023cites this paper
• Targeted Polymersome Delivery of a Stapled Peptide for Drugging the Tumor Protein p53:BCL-2-Family Axis in Diffuse Large B-Cell Lymphoma

  2023cites this paper
• A VEGFB-Based Peptidomimetic Inhibits VEGFR2-Mediated PI3K/Akt/mTOR and PLCγ/ERK Signaling and Elicits Apoptotic, Antiangiogenic, and Antitumor Activities

  2023cites this paper
• Bilirubin, an endogenous antioxidant that affects p53 protein and its downstream apoptosis/autophagy-related genes in LS180 and SW480 cell culture models of colorectal cancer.

  2023cites this paper
• Raptinal ameliorates 1,2-dimethylhydrazine-induced colon cancer through p53/Bcl2/Bax/caspase-3-mediated apoptotic events in vitro and in vivo

  2023cites this paper
• A multibiomarker approach to assess the ecotoxicological effects of diclofenac on Asian clam Corbicula fluminea (O. F. Müller, 1774)

  2023cites this paper
• Early Growth Response 1 Contributes to Renal IR Injury by Inducing Proximal Tubular Cell Apoptosis

  2023cites this paper
• The crosstalk between ubiquitin-conjugating enzyme E2Q1 and p53 in colorectal cancer: An in vitro analysis

  2023cites this paper
• Iron deficiency in hepatocellular carcinoma cells induced sorafenib resistance by upregulating HIF-1α to inhibit apoptosis.

  2023cites this paper
• Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits.

  2023cites this paper
• The role of truncated p53 isoforms in the DNA damage response.

  2023cites this paper
• Ruthenium biochanin-A complex ameliorates lung carcinoma through the downregulation of the TGF-β/PPARγ/PI3K/TNF-α pathway in association with caspase-3-mediated apoptosis

  2023cites this paper
• An 8q24 Gain in Pancreatic Juice Is a Candidate Biomarker for the Detection of Pancreatic Cancer

  2023cites this paper
• Pyrogallol promotes growth arrest by activating the p53‐mediated up‐regulation of p21 and p62/SQSTM1‐dependent degradation of β‐catenin in nonsmall cell lung cancer cells

  2023cites this paper
• Epigenetic alterations of miR-155 and global DNA methylation as potential mediators of ochratoxin A cytotoxicity and carcinogenicity in human lung fibroblasts

  2023cites this paper
• Comparative study on antioxidant activity of Gold 1, a new strain of Pyropia yezoensis

  2023cites this paper
• Antineoplastic effect of paclitaxel-loaded polymeric nanocapsules on malignant human ovarian carcinoma cells (SKOV-3)

  2023cites this paper
• Aberrant immunoexpression of p53 tumour-suppressor and Bcl-2 family proteins (Bcl-2 and Bax) in ameloblastomas and odontogenic keratocysts

  2023influential citation
• GPER deletion triggers inhibitory effects in triple negative breast cancer (TNBC) cells through the JNK/c-Jun/p53/Noxa transduction pathway

  2023cites this paper
• MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism

  2023cites this paper
• Uptake and toxicity of micro-/nanoplastics derived from naturally weathered disposable face masks in developing zebrafish: Impact of COVID-19 pandemic on aquatic life.

  2023cites this paper
• In vivo exposure to bisphenol F induces oxidative testicular toxicity: role of Erβ and p53/Bcl-2 signaling pathway

  2023cites this paper
• Potential applications of N6‐methyladenosine modification in the prognosis and treatment of cancers via modulating apoptosis, autophagy, and ferroptosis

  2022cites this paper
• Sodium metabisulfite in dried plum and its cytotoxic effects on K-562 and L-929 normal cell lines.

  2022cites this paper
• The Ribosomal Protein L5 Functions During Xenopus Anterior Development Through Apoptotic Pathways

  2022cites this paper
• p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors

  2022influential citation
• Interaction studies of flavonoids with Bcl-2 protein to re-activate apoptosis in JurkatT-cells by induced TRAIL

  2022cites this paper
• Growth Inhibition and Apoptotic Effect of Pine Extract and Abietic Acid on MCF-7 Breast Cancer Cells via Alteration of Multiple Gene Expressions Using In Vitro Approach

  2022cites this paper