Gene delivery with low molecular weight linear polyethylenimines

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Gene Medicine

• Publication date

  2005-10-01

• Fields of study

  Biology, Medicine, Materials Science

• Identifiers
  DOI 10.1002/jgm.775PMID 15906395
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Biology, Nucleic Acids, and the Future of Medicine

  2015cited by this paper
• Flow cytofluorometric analysis of insulin binding and internalization by Swiss 3T3 cells.

  2005cited by this paper
• Insertional oncogenesis in gene therapy: how much of a risk?

  2004cited by this paper
• Synthesis and application of low molecular weight linear polyethylenimines for non-viral gene delivery

  2004cited by this paper
• Quantitation of the lysosomotropic character of cationic amphiphilic drugs using the fluorescent basic amine Red DND-99.

  2004cited by this paper
• Polyplexes of polyethylenimine and per-N-methylated polyethylenimine-cytotoxicity and transfection efficiency.

  2004cited by this paper
• The dual mechanism of the antifungal effect of new lysosomotropic agents on the Saccharomyces cerevisiae RXII strain.

  2003cited by this paper
• Effect of Ethanol on Lipid‐Mediated Transfection of Primary Cortical Neurons

  2003cited by this paper
• Synthesis of linear polyethylenimine derivatives for DNA transfection.

  2003cited by this paper
• Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine.

  2003cited by this paper
• A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo

  2003cited by this paper
• Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes*

  2003cited by this paper
• Structural Basis of Protein-bound Endogenous Aldehydes

  2003cited by this paper
• Intracellular route and transcriptional competence of polyethylenimine-DNA complexes.

  2002cited by this paper
• How much risk

  2002cited by this paper
• What to Do When Clear Success Comes With an Unclear Risk?

  2002cited by this paper
• Intracellular Processing of Poly(Ethylene Imine)/Ribozyme Complexes Can Be Observed in Living Cells by Using Confocal Laser Scanning Microscopy and Inhibitor Experiments

  2002cited by this paper
• Overcoming the nuclear barrier: cell cycle independent nonviral gene transfer with linear polyethylenimine or electroporation.

  2002cited by this paper
• Enhanced plasmid DNA transfection with lysosomotropic agents in cultured fibroblasts.

  2001cited by this paper
• Polyethylenimine‐mediated gene delivery: a mechanistic study

  2001cited by this paper
• Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viability.

  2001cited by this paper
• Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo

  2001cited by this paper
• Poly(ethylenimine)-mediated transfection: a new paradigm for gene delivery.

  2000cited by this paper
• Rapid crossing of the pulmonary endothelial barrier by polyethylenimine/DNA complexes

  2000cited by this paper
• Endosomes, lysosomes: their implication in gene transfer.

  2000cited by this paper
• Poly(ethylenimine) and its role in gene delivery.

  1999cited by this paper
• Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle.

  1999cited by this paper
• Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs

  1999cited by this paper
• The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells

  1998cited by this paper
• Polyethylenimine-based intravenous delivery of transgenes to mouse lung

  1998cited by this paper
• Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system

  1998cited by this paper
• ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo

  1997cited by this paper
• Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold.

  1996cited by this paper
• A Powerful Nonviral Vector for In Vivo Gene Transfer into the Adult Mammalian Brain: Polyethylenimine

  1996cited by this paper
• A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

  1995cited by this paper
• Fusion of cationic liposomes with mammalian cells occurs after endocytosis.

  1995cited by this paper
• Assay of vacuolar pH in yeast and identification of acidification-defective mutants.

  1989cited by this paper
• Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

  1988cited by this paper
• Influence of the Injection of a Sucrose Solution on the Properties of Rat-liver Lysosomes

  1964cited by this paper

• Thioester platform to develop potential nanomedicines for breast cancer therapy

  2025cites this paper
• Simultaneous targeting of TGF-β1/PD-L1 via a hydrogel-nanoparticle system to remodel the ECM and immune microenvironment for limiting adhesion formation.

  2024cites this paper
• An Antibody‐CRISPR/Cas Conjugate Platform for Target‐Specific Delivery and Gene Editing in Cancer

  2024cites this paper
• Synthesis and evaluation of gene delivery vectors based on PEI-modified metal-organic framework (MOF) nanoparticles

  2024cites this paper
• Chemically engineered polyethylenimine conjugates for mannose receptor-mediated gene delivery with potential antimicrobial and anticancer activity

  2024cites this paper
• Advances in the polymeric delivery of nucleic acid vaccines

  2022cites this paper
• Synthesis of coumarin-containing poly(2-oxazoline)s and light-induced crosslinking for hydrogel formation

  2022cites this paper
• Non-Viral Delivery of Gene Therapy to the Tendon

  2022cites this paper
• Polymeric Delivery of Therapeutic Nucleic Acids.

  2021cites this paper
• Smart arginine-equipped polycationic nanoparticles for p/CRISPR delivery into cells

  2021cites this paper
• Effect of Plasmid DNA Size on Chitosan or Polyethyleneimine Polyplexes Formulation

  2021cites this paper
• Nanoparticles for local delivery of siRNA in lung therapy.

  2021cites this paper
• Intracellular Delivery of Proteins into Living Cells by Low-Molecular-Weight Polyethyleneimine

  2021cites this paper
• A diaminoethane motif bearing low molecular weight polymer as a new nucleic acid delivery agent

  2021cites this paper
• Non-Viral in Vitro Gene Delivery: It is Now Time to Set the Bar!

  2020influential citation
• Fluorescent Labels for Reduction Sensitive Polycationic Gene Carriers

  2020cites this paper
• Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

  2019cites this paper
• Novel Oligo-Guanidyl-PEG Carrier Forming Rod-Shaped Polyplexes.

  2019cites this paper
• Rapidly Visualizing the Membrane Affinity of Gene Vectors Using Polydiacetylene-Based Allochroic Vesicles.

  2019cites this paper
• Lag Time Spectrophotometric Assay for Studying Transport Limitation in Immobilized Enzymes

  2018cites this paper
• N-Heterocyclic Carbene-Polyethyleneimine (PEI) Platinum Complexes Inducing Human Cancer Cell Death: Polymer Carrier Impact

  2018cites this paper
• Rethinking the impact of the protonable amine density on cationic polymers for gene delivery: A comparative study of partially hydrolyzed poly(2‐ethyl‐2‐oxazoline)s and linear poly(ethylene imine)s

  2018cites this paper
• Nonviral Delivery Systems for Gene Therapy for Retina and Posterior Segment Disease

  2018cites this paper
• N-Heterocyclic Carbene-PEI Platinum Complexes Inducing Human Cancer Cell Death: Polymer Carrier Impact

  2018cites this paper
• UNIVERSITY OF CALIFORNIA, IRVINE Linear Polyethylenimine Self-Assembly Polymer as a Nanopatterning Template to Prevent Bacteria Adhesion and Biofilm Formation THESIS Submitted in partial satisfaction of the requirements for the degree of MASTER OF SCIENCE in Materials Science and Engineering by

  2018cites this paper
• Gene delivery nanoparticles to modulate angiogenesis☆

  2017cites this paper
• Engineered polymeric amphiphiles self-assembling into nanostructures and acting as efficient gene and drug carriers

  2017cites this paper
• Lipoplexes and Polyplexes: Gene Therapy

  2017cites this paper
• Self-assembled core–shell-corona multifunctional non-viral vector with AIE property for efficient hepatocyte-targeting gene delivery

  2017cites this paper
• Nanoparticles for radiooncology: Mission, vision, challenges.

  2017cites this paper
• [Synthesis, characterization and antitumor activity of 5-fluorouracil-nicotinamide cocrystal].

  2017cites this paper
• Challenges in DNA Delivery and Recent Advances in Multifunctional Polymeric DNA Delivery Systems.

  2017cites this paper
• Lipopolyplex for Therapeutic Gene Delivery and Its Application for the Treatment of Parkinson’s Disease

  2016cites this paper
• Preparation of poly(ethylene imine) derivatives with precisely controlled molecular weight

  2016cites this paper
• Optimized polyethylenimine (PEI)-based nanoparticles for siRNA delivery, analyzed in vitro and in an ex vivo tumor tissue slice culture model

  2016cites this paper
• Bioreducible Fluorinated Peptide Dendrimers Capable of Circumventing Various Physiological Barriers for Highly Efficient and Safe Gene Delivery.

  2016cites this paper
• A novel tyrosine-modified low molecular weight polyethylenimine (P10Y) for efficient siRNA delivery in vitro and in vivo.

  2016cites this paper
• Linear polyethyleneimine-doxorubicin conjugate for pH-responsive synchronous delivery of drug and microRNA-34a

  2015cites this paper
• Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted siRNA Delivery to HER2+ Breast Cancer

  2015cites this paper
• Linear polyethylenimine-plasmid DNA nanoparticles are ototoxic to the cultured sensory epithelium of neonatal mice.

  2015cites this paper
• Cytoplasmic Reactive Cationic Amphiphiles for Efficient Intracellular Delivery and Self-Reporting Smart Release

  2015cites this paper
• Poly(2-oxazoline)s and their derivatives : a versatile polymer class with manifold application possibilities

  2015influential citation
• Fluorescence Imaging of siRNA Delivery by Peptide Nucleic Acid-based Probe

  2015cites this paper
• Regulation of endocytosis by non-viral vectors for efficient gene activity.

  2014cites this paper
• In-vitro cytotoxicity of Polyethyleneimine on HeLa and Vero Cells

  2014cites this paper
• Non-viral vectors for gene-based therapy

  2014cites this paper
• Poly(2-oxazoline)s

  2014cites this paper
• Cationic Polymers for the Delivery of Therapeutic Nucleotides

  2014cites this paper
• Assembly of polyethylenimine-functionalized iron oxide nanoparticles as agents for DNA transfection with magnetofection technique.

  2014cites this paper
• Poly(2-oxazoline)s as materials for biomedical applications

  2014cites this paper
• Dextran-graft-linear poly(ethylene imine)s for gene delivery: importance of the linking strategy.

  2014cites this paper
• Fast and accurate partial hydrolysis of poly(2-ethyl-2-oxazoline) into tailored linear polyethylenimine copolymers

  2014cites this paper
• Interaction of Polyethylenimine with Model Cell Membranes Studied by Linear and Nonlinear Spectroscopic Techniques

  2014cites this paper
• Tailored polymeric nanoparticles for gene delivery and diagnostic

  2013cites this paper
• Examination of the effect of increasing the number of intra-disulfide amino functional groups on the performance of small molecule cyclic polyamine disulfide vectors.

  2013cites this paper
• - Lipoplexes and Polyplexes: From Gene Delivery to Gene Expression

  2013cites this paper
• Biodegradable nanoparticles for gene therapy technology

  2013cites this paper
• Oligobenzylethylenimine enriches linear polyethylenimine with a pH-sensitive membrane-disruptive property and leads to enhanced gene delivery activity.

  2013cites this paper
• Nanomaterials for Mirna Delivery and Non-Invasive Imaging in Cardiovascular Regeneration

  2013cites this paper
• Identification of peptides capable of targeting immature dendritic cells using phage display

  2012cites this paper
• A review of RGD-functionalized nonviral gene delivery vectors for cancer therapy

  2012cites this paper
• Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity.

  2012cites this paper
• Effects of trehalose polycation end-group functionalization on plasmid DNA uptake and transfection.

  2012cites this paper
• Quantitative comparison between poly(L-arginine) and poly(L-lysine) at each step of polyplex-based gene transfection using a microinjection technique

  2012cites this paper
• A library of strictly linear poly(ethylene glycol)-poly(ethylene imine) diblock copolymers to perform structure-function relationship of non-viral gene carriers.

  2012cites this paper
• Poly(ethylene imine)s as antimicrobial agents with selective activity.

  2012cites this paper
• Synthesis of cyclic polyamines by enzymatic generation of an amino aldehyde in situ.

  2012cites this paper
• Design and Development of Degradable Polyethylenimines for Delivery of DNA and Small Interfering RNA: An Updated Review

  2012cites this paper
• Biodegradable amphiphilic PEG-PCL-PEI triblock copolymers designed for the self-assembly of multifunctional gene carriers

  2012cites this paper
• Polyelectrolyte complexes of DNA and linear PEI: formation, composition and properties.

  2012cites this paper
• Highly Effective Gene Transfection In Vivo by Alkylated Polyethylenimine

  2011influential citation
• Accelerated gene transfer through a polysorbitol-based transporter mechanism.

  2011influential citation
• Regulation of the prostate-specific hTGP (TGM4) gene and its potential use for prostate cancer gene therapy

  2011influential citation
• Toxicity of Polymeric-Based Non-Viral Vector Systems for Pulmonary siRNA Application

  2011cites this paper
• Revisit complexation between DNA and polyethylenimine--effect of length of free polycationic chains on gene transfection.

  2011cites this paper
• Gene transfer efficacies of serum-resistant amino acids-based cationic lipids: dependence on headgroup, lipoplex stability and cellular uptake.

  2011cites this paper
• Revisit complexation between DNA and polyethylenimine - Effect of uncomplexed chains free in the solution mixture on gene transfection.

  2011cites this paper
• Self-assembled siRNA-PLGA conjugate micelles for gene silencing.

  2011cites this paper
• Polymers in Drug Delivery—State of the Art and Future Trends

  2011cites this paper
• Mechanism of gene transfection by polyamidoamine (PAMAM) dendrimers modified with ornithine residues

  2011cites this paper
• A Comparative Evaluation of Disulfide-Linked and Hydrophobically-Modified PEI for Plasmid Delivery

  2011cites this paper
• Effect of Chain Length on Cytotoxicity and Endocytosis of Cationic Polymers

  2011cites this paper
• The characterisation of a recombinant cytosolic shuttle based on ricin toxin

  2011cites this paper
• Poly(2-aminoethyl methacrylate) with well-defined chain length for DNA vaccine delivery to dendritic cells.

  2011cites this paper
• Emulsion Electrospinning for Producing Dome-Shaped Structures Within L-Tyrosine Polyurethane Scaffolds for Gene Delivery

  2010cites this paper
• Folate receptor mediated gene targeting:comparative evaluation of natural and synthetic polymer based nanoparticles

  2010cites this paper
• Characterisation of plasmid DNA complexes for application in genetic immunization

  2010cites this paper
• Characterization of nanoscale transformations in polyelectrolyte multilayers fabricated from plasmid DNA using laser scanning confocal microscopy in combination with atomic force microscopy

  2010cites this paper
• Biodegradable branched polycationic polymers as non-viral gene delivery vectors for bone tissue engineering

  2010cites this paper
• Specific and efficient in vivo delivery of DNA and siRNA by polyethylenimine and its derivatives

  2010cites this paper
• High‐level recombinant protein production in CHO cells using lentiviral vectors and the cumate gene‐switch

  2010cites this paper
• Ternary nanoparticles of anionic lipid nanoparticles/protamine/DNA for gene delivery.

  2010cites this paper
• In vitro transfection of HSC-T6 cells with a novel poly(ethyleneimine) biscarbamate conjugate

  2010cites this paper
• New-generation biomedical materials: Peptide dendrimers and their application in biomedicine

  2010cites this paper
• Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking.

  2010cites this paper
• Altering amine basicities in biodegradable branched polycationic polymers for nonviral gene delivery.

  2010cites this paper
• Bioresponsive small molecule polyamines as noncytotoxic alternative to polyethylenimine.

  2010cites this paper
• Efficient gene transfection using novel cationic polymers poly(hydroxyalkylene imines).

  2010cites this paper
• Endosomal disruptors in non-viral gene delivery

  2010cites this paper
• Quantum dots synthesis and biological applications as imaging and drug delivery systems

  2010cites this paper