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Modulatory role of Epigallocatechin-3-Gallate (EGCG) on Male and Female Reproductive disorders.

N. Roy,Sarika Borle,Dipty Singh

Published 2025 in Reproductive Toxicology

ABSTRACT

Epigallocatechin-3-gallate (EGCG), a key bioactive compound in green tea, has gained prominence in recent years due to its numerous health-promoting benefits. Owing to its potent antioxidant, anti-inflammatory, and hormone-modulating properties, EGCG represents a promising therapeutic candidate for the management of andrological, gynecological, and pregnancy-associated disorders. In males, oxidative stress is a major factor in sperm dysfunction, leading to poor motility, abnormal morphology, and DNA fragmentation. EGCG enhances sperm quality by reducing oxidative damage, improving testosterone levels, mitigating testicular inflammation and protecting against environmental toxins that contribute to male infertility. In females, EGCG supports ovarian function, improves oocyte quality, and helps regulate hormonal imbalances by modulating estrogen synthesis, reducing inflammatory markers, and preventing abnormal cell proliferation in various gynaecological disorders. Additionally, its anti-cancer properties suggest a protective effect against prostate, ovarian, cervical, and endometrial cancers. During pregnancy, oxidative stress and inflammation can contribute to complications such as preeclampsia, gestational diabetes, and fetal alcohol syndrome. EGCG's ability to enhance vascular health, improve placental function, and regulate immune responses suggests its potential in promoting a healthy pregnancy and fetal development. Though evidences support the merits of EGCG in reproductive health scenario, further research is needed to establish optimal dosages and long-term safety. This narrative review examines the therapeutic potential of EGCG in male and female reproductive disorders, as well as pregnancy, highlighting its antioxidant, anti-inflammatory, anti-cancer, anti-apoptosis and hormone-regulating properties. Additionally, it incorporates recent findings demonstrating the integration of EGCG into reproductive healthcare offering a promising natural therapeutic approach to improve fertility and pregnancy outcomes.

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