Heterogeneity and characteristic changes in cardiomyocytes and non-cardiomyocytes following myocardial infarction: Insights from single-cell sequencing analysis (Review)

Myocardial infarction (MI) is an important pathological event in cardiovascular disease and the heterogeneous changes in cardiomyocytes and non-cardiomyocytes that occur following its occurrence have a profound effect on cardiac repair and functional recovery. Single-cell sequencing, a novel technology for the analysis of tissues at the single-cell level, permits a comprehensive insight into the heterogeneity of different cell populations. The current review presented a summary of the application of single-cell sequencing to detect the heterogeneity of cardiomyocytes and non-cardiomyocytes following MI. It focused on the classification and changes of cell clusters and explored the mechanisms of post-infarction cardiac regeneration and remodeling with the aim of providing a theoretical foundation for identifying potential targets to enhance the diagnosis and treatment of post-infarction cardiac remodeling.

• Publication year

  2025

• Venue

  Molecular Medicine Reports

• Publication date

  2025-09-10

• Fields of study

  Medicine

• Identifiers
  DOI 10.3892/mmr.2025.13680PMID 40937583PMCID 12452225
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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