Enhancement of response learning in male rats with intrastriatal infusions of a BDNF -TrkB agonist, 7,8-dihydroxyflavone.

No abstract is available for this paper.

• Publication year

  2025

• Venue

  Behavioural Brain Research

• Publication date

  2025-09-09

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.bbr.2025.115816PMID 40935120
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Exploring the Connection Between BDNF/TrkB and AC/cAMP/PKA/CREB Signaling Pathways: Potential for Neuroprotection and Therapeutic Targets for Neurological Disorders

  2025cited by this paper
• 7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia

  2024cited by this paper
• Exploring the memory: existing activity-dependent tools to tag and manipulate engram cells

  2024cited by this paper
• Mechanisms of the Beneficial Effects of Exercise on Brain-Derived Neurotrophic Factor Expression in Alzheimer’s Disease

  2023cited by this paper
• Early 7,8-Dihydroxyflavone Administration Ameliorates Synaptic and Behavioral Deficits in the Young FXS Animal Model by Acting on BDNF-TrkB Pathway

  2023cited by this paper
• 7,8-dihydroxyflavone enhances long-term spatial memory and alters brain volume in wildtype mice

  2023cited by this paper
• Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction

  2023cited by this paper
• BDNF and Lactate as Modulators of Hippocampal CA3 Network Physiology

  2023cited by this paper
• The role of progesterone in memory bias during spatial navigation in females

  2022cited by this paper
• nDysfunction of the BDNF-TrkB signaling pathway contributes to learning and memory impairments induced by neuroinflammation in mice.

  2022cited by this paper
• Memory Related Molecular Signatures: The Pivots for Memory Consolidation and Alzheimer's Related Memory Decline.

  2022cited by this paper
• The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases

  2022cited by this paper
• 7,8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer’s disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance

  2021cited by this paper
• 7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development

  2021cited by this paper
• Hippocampus-sensitive and striatum-sensitive learning one month after morphine or cocaine exposure in male rats

  2021cited by this paper
• 7,8-dihydroxyflavone ameliorates motor deficits via regulating autophagy in MPTP-induced mouse model of Parkinson’s disease

  2021cited by this paper
• Moderate Exercise Combined with Enriched Environment Enhances Learning and Memory through BDNF/TrkB Signaling Pathway in Rats

  2021cited by this paper
• NEURAL SYSTEMS AND THE EMOTION-MEMORY LINK.

  2021cited by this paper
• Inactivation of the striatum in aged rats rescues their ability to learn a hippocampus-sensitive spatial navigation task.

  2020cited by this paper
• 7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence

  2020cited by this paper
• Gait deficits and loss of striatal tyrosine hydroxlase/trk-b are restored following 7,8-dihydroxyflavone treatment in a progressive mptp mouse model of parkinson's disease.

  2020cited by this paper
• Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

  2020cited by this paper
• Glucose signaling in the brain and periphery to memory.

  2020cited by this paper
• Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death

  2020cited by this paper
• 7,8-Dihydroxyflavone improves neuropathological changes in the brain of Tg26 mice, a model for HIV-associated neurocognitive disorder

  2020cited by this paper
• Striatal and hippocampal contributions to flexible navigation in rats and humans

  2020cited by this paper
• Rottlerin, BDNF, and the impairment of inhibitory avoidance memory

  2020cited by this paper
• Evaluation of a TrkB agonist on spatial and motor learning in the Ube3a mouse model of Angelman syndrome

  2020cited by this paper
• Negative correlation between grey matter in the hippocampus and caudate nucleus in healthy aging.

  2020cited by this paper
• Extracellular levels of glucose in the hippocampus and striatum during maze training for food or water reward in male rats

  2020cited by this paper
• Timing of Treatment with the Flavonoid 7,8-DHF Critically Impacts on Its Effects on Learning and Memory in the Ts65Dn Mouse

  2019cited by this paper
• TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins

  2019cited by this paper
• A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability

  2019cited by this paper
• Modulation of synaptic plasticity by exercise.

  2019cited by this paper
• On the Involvement of BDNF Signaling in Memory Reconsolidation

  2019cited by this paper
• Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

  2019cited by this paper
• Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum

  2019cited by this paper
• Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines

  2019cited by this paper
• Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability

  2018cited by this paper
• Exercise-Mediated Neurogenesis in the Hippocampus via BDNF

  2018cited by this paper
• A new perspective of the hippocampus in the origin of exercise–brain interactions

  2018cited by this paper
• Bridging the Gap between Brain-Derived Neurotrophic Factor and Glucocorticoid Effects on Brain Networks

  2018cited by this paper
• Physical exercise improves cognitive function by enhancing hippocampal neurogenesis and inhibiting apoptosis in male offspring born to obese mother

  2018cited by this paper
• 7,8-Dihydroxyflavone facilitates the action exercise to restore plasticity and functionality: Implications for early brain trauma recovery.

  2017cited by this paper
• 7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington’s disease mouse model through specific activation of the PLC&ggr;1 pathway

  2017cited by this paper
• Glycogenolysis, an Astrocyte-Specific Reaction, is Essential for Both Astrocytic and Neuronal Activities Involved in Learning.

  2017cited by this paper
• BDNF and Hippocampal Synaptic Plasticity.

  2017cited by this paper
• Phosphorylation of Tyrosine Receptor Kinase B in the Dorsal Striatum and Dorsal Hippocampus Is Associated With Response Learning in a Water Plus Maze

  2017cited by this paper
• The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels.

  2017cited by this paper
• Using a memory systems lens to view the effects of estrogens on cognition: Implications for human health.

  2017cited by this paper
• Impaired Spatial Memory and Enhanced Habit Memory in a Rat Model of Post-traumatic Stress Disorder

  2017cited by this paper
• Training‐induced elevations in extracellular lactate in hippocampus and striatum: Dissociations by cognitive strategy and type of reward

  2017cited by this paper
• A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus‐dependent memory in the Ts65Dn mouse model of DS

  2017cited by this paper
• 7,8‐dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α‐synuclein Expression and Oxidative Stress in the MPTP‐induced Mouse Model of Parkinson's Disease

  2016cited by this paper
• TrkB activation by 7, 8‐dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease

  2016cited by this paper
• Intervention with 7,8-dihydroxyflavone blocks further striatal terminal loss and restores motor deficits in a progressive mouse model of Parkinson's disease.

  2015cited by this paper
• Motor Skill Learning Is Associated with Phase-Dependent Modifications in the Striatal cAMP/PKA/DARPP-32 Signaling Pathway in Rodents

  2015cited by this paper
• BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment

  2015cited by this paper
• Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation.

  2015cited by this paper
• 7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome.

  2015cited by this paper
• Estrogens and cognition: Friends or foes?: An evaluation of the opposing effects of estrogens on learning and memory.

  2015cited by this paper
• 7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

  2014cited by this paper
• Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia.

  2014cited by this paper
• Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies.

  2014cited by this paper
• 7,8-Dihydroxyflavone, a Small Molecule TrkB Agonist, Improves Spatial Memory and Increases Thin Spine Density in a Mouse Model of Alzheimer Disease-Like Neuronal Loss

  2014cited by this paper
• Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-Dihydroxyflavone in the Binding and Activation of the TrkB Receptor*

  2014cited by this paper
• BDNF and synaptic plasticity, cognitive function, and dysfunction.

  2014cited by this paper
• BDNF and memory processing.

  2014cited by this paper
• 7,8-Dihydroxyflavone Ameliorates Scopolamine-Induced Alzheimer-Like Pathologic Dysfunction

  2014cited by this paper
• Brain-derived neurotrophic factor-estrogen interactions in the hippocampal mossy fiber pathway: implications for normal brain function and disease.

  2013cited by this paper
• Dissociation of memory systems: The story unfolds.

  2013cited by this paper
• Modulation of multiple memory systems: From neurotransmitters to metabolic substrates

  2013cited by this paper
• Effects of lentivirus‐mediated CREB expression in the dorsolateral striatum: Memory enhancement and evidence for competitive and cooperative interactions with the hippocampus

  2013cited by this paper
• Factors that influence the relative use of multiple memory systems

  2013cited by this paper
• Homeostatic Regulation of Memory Systems and Adaptive Decisions

  2013cited by this paper
• 7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice.

  2013cited by this paper
• Use it and boost it with physical and mental activity

  2013cited by this paper
• Activation of TrkB by 7,8-Dihydroxyflavone Prevents Fear Memory Defects and Facilitates Amygdalar Synaptic Plasticity in Aging

  2012cited by this paper
• 7,8‐dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats

  2012cited by this paper
• 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

  2012cited by this paper
• Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable?

  2011cited by this paper
• Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning.

  2011cited by this paper
• Intra-striatal estradiol in female rats impairs response learning within two hours of treatment.

  2011cited by this paper
• A Simple Role for BDNF in Learning and Memory?

  2009cited by this paper
• Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation.

  2009cited by this paper
• TrkB signalling pathways in LTP and learning

  2009cited by this paper
• Transfection of mutant CREB in the striatum, but not the hippocampus, impairs long-term memory for response learning.

  2008cited by this paper
• Habits, rituals, and the evaluative brain.

  2008cited by this paper
• Small-Conductance Ca2+-Activated K+ Channel Type 2 (SK2) Modulates Hippocampal Learning, Memory, and Synaptic Plasticity

  2006cited by this paper
• Effects of injections of glucose into the dorsal striatum on learning of place and response mazes.

  2006cited by this paper
• Regulation of Amygdala-Dependent Learning by Brain-Derived Neurotrophic Factor is Mediated by Extracellular Signal-Regulated Kinase and Phosphatidylinositol-3-Kinase

  2006cited by this paper
• Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B Involvement in Amygdala-Dependent Fear Conditioning

  2004cited by this paper
• Inactivation of dorsolateral striatum impairs acquisition of response learning in cue-deficient, but not cue-available, conditions.

  2004cited by this paper
• Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition

  2004cited by this paper
• Shifts in preferred learning strategy across the estrous cycle in female rats.

  2004cited by this paper
• Role of estrogen in balancing contributions from multiple memory systems.

  2004cited by this paper
• From modulator to mediator: rapid effects of BDNF on ion channels

  2004cited by this paper
• Brain-derived neurotrophic factor/TrkB signaling in memory processes.

  2003cited by this paper
• Involvement of BDNF receptor TrkB in spatial memory formation.

  2003cited by this paper
• Mechanism of TrkB-mediated hippocampal long-term potentiation.

  2002cited by this paper

• No citing papers are available for this paper.