Single-cell MALDI-MS as an analytical tool for studying intrapopulation metabolic heterogeneity of unicellular organisms.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Analytical Chemistry

• Publication date

  2010-08-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/ac1015326PMID 20707357
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An ATP fluorescent chemosensor based on a Zn(II)-complexed dipicolylamine receptor coupled with a naphthalimide chromophore.

  2010cited by this paper
• Growth-limiting Intracellular Metabolites in Yeast Growing under Diverse Nutrient Limitations

  2010cited by this paper
• Support vector machines for classification and regression.

  2010cited by this paper
• Integrated microfluidic device for automated single cell analysis using electrophoretic separation and electrospray ionization mass spectrometry.

  2010cited by this paper
• MALDI-MS-based high-throughput metabolite analysis for intracellular metabolic dynamics.

  2010cited by this paper
• Matrix-free UV-laser desorption/ionization (LDI) mass spectrometric imaging at the single-cell level: distribution of secondary metabolites of Arabidopsis thaliana and Hypericum species.

  2009cited by this paper
• MALDI mass spectrometric imaging using the stretched sample method to reveal neuropeptide distributions in aplysia nervous tissue.

  2009cited by this paper
• Capillary electrophoresis with electrospray ionization mass spectrometric detection for single-cell metabolomics.

  2009cited by this paper
• Acid–base-driven matrix-assisted mass spectrometry for targeted metabolomics

  2009cited by this paper
• In situ metabolic profiling of single cells by laser ablation electrospray ionization mass spectrometry.

  2009cited by this paper
• Application of pressure probe and UV-MALDI-TOF MS for direct analysis of plant underivatized carbohydrates in subpicoliter single-cell cytoplasm extract

  2008cited by this paper
• A genetically encoded fluorescent reporter of ATP/ADP ratio

  2008cited by this paper
• Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification.

  2008cited by this paper
• Metabolomics: Biochemistry's new look

  2008cited by this paper
• Nature, nurture, or chance: stochastic gene expression and its consequences.

  2008cited by this paper
• Preparation of single cells for imaging/profiling mass spectrometry

  2008cited by this paper
• 4-Chloro-α-cyanocinnamic acid is an advanced, rationally designed MALDI matrix

  2008cited by this paper
• A new dynamic in mass spectral imaging of single biological cells.

  2008cited by this paper
• Multiple ionization mass spectrometry strategy used to reveal the complexity of metabolomics.

  2008cited by this paper
• Individuality in bacteria.

  2008cited by this paper
• Chemical cytometry: fluorescence-based single-cell analysis.

  2008cited by this paper
• Matrix-free methods for laser desorption/ionization mass spectrometry.

  2007cited by this paper
• Clathrate nanostructures for mass spectrometry

  2007cited by this paper
• Mass spectrometry-based metabolomics.

  2007cited by this paper
• Characterizing peptides in individual mammalian cells using mass spectrometry

  2007cited by this paper
• Microbial cell individuality and the underlying sources of heterogeneity

  2006cited by this paper
• Molecular weight determination of peptides and proteins by ESI and MALDI.

  2005cited by this paper
• Metabolomic analysis of eukaryotic tissue and prokaryotes using negative mode MALDI time-of-flight mass spectrometry.

  2005cited by this paper
• Counting the cost of a cold-blooded life: metabolomics of cold acclimation.

  2004cited by this paper
• cAMP detection methods in HTS: selecting the best from the rest

  2004cited by this paper
• Development of the Single-Cell MALDI-TOF (Matrix-Assisted Laser Desorption/Ionization Time-of-Flight) Mass-Spectroscopic Assay

  2003cited by this paper
• Visualization of maltose uptake in living yeast cells by fluorescent nanosensors

  2002cited by this paper
• Support vector machine classification and validation of cancer tissue samples using microarray expression data

  2000cited by this paper
• Direct analysis of single rat peritoneal mast cells with laser vaporization/ionization mass spectrometry.

  1998cited by this paper
• A Fluorescent Modification of Adenosine Triphosphate with Activity in Enzyme Systems: 1,N6-Ethenoadenosine Triphosphate

  1972cited by this paper

• Enabling Live Single-Cell Metabolomics: Mass Spectrometry Technologies and Functional Applications

  2026cites this paper
• Discrimination of Microalgal Cellular Metabolic Heterogeneity and 13C Metabolic Flux Analysis via Micro Label-Free Mass Cytometry.

  2025cites this paper
• Multi-modal single-cell platform for nanoparticle-enhanced time-series metabolic profiles of CD8+ T cell exhaustion in tumor immunosurveillance

  2025cites this paper
• Developing a Cell Quenching Method to Facilitate Single Cell Mass Spectrometry Metabolomics Studies

  2025cites this paper
• Unravelling lipid heterogeneity: Advances in single-cell lipidomics in cellular metabolism and disease

  2025cites this paper
• Bacteriophage-driven microbial phenotypic heterogeneity: ecological and biogeochemical importance

  2025cites this paper
• To image or not to image: Use of imaging mass spectrometry in biomedical lipidomics.

  2025cites this paper
• Mass‐Guided Single‐Cell MALDI Imaging of Low‐Mass Metabolites Reveals Cellular Activation Markers

  2024cites this paper
• Deciphering breast cancer dynamics: insights from single-cell and spatial profiling in the multi-omics era

  2024cites this paper
• MALDI Mass Spectrometry on High-Density Droplet Arrays: Matrix Deposition, Selective Removal, and Recrystallization

  2024cites this paper
• From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling

  2024cites this paper
• Development of a 3D-Printed Ionization Source for Single-Cell Analysis.

  2023cites this paper
• Metabolomics: a useful tool for ischemic stroke research

  2023cites this paper
• Metabolomics in drug research and development: The recent advances in technologies and applications

  2023cites this paper
• Methods developments of mass spectrometry based single cell metabolomics

  2023cites this paper
• Quantifying Cell Heterogeneity and Subpopulations Using Single Cell Metabolomics.

  2023cites this paper
• Advances in Mass Spectrometry-Based Single Cell Analysis

  2023cites this paper
• Nanocapillary sampling coupled to liquid chromatography mass spectrometry delivers single cell drug measurement and lipid fingerprints

  2023cites this paper
• Microfluidics Coupled Mass Spectrometry for Single Cell Multi‐Omics

  2023cites this paper
• Opportunities and challenges for sample preparation and enrichment in mass spectrometry for single‐cell metabolomics

  2023cites this paper
• Laser-Assisted Recovery of On-Chip Phage Viral DNA for Phage Fluorescence Immunoassay Microchip

  2023cites this paper
• Microfluidics add-on technologies for single-cell analysis

  2023cites this paper
• RespectM revealed metabolic heterogeneity powers deep learning for reshaping the DBTL cycle

  2023cites this paper
• Mass spectrometry imaging to explore molecular heterogeneity in cell culture

  2022cites this paper
• Nanokit coupled electrospray ionization mass spectrometry for analysis of angiotensin converting enzyme 2 activity in single living cell

  2022cites this paper
• High-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneity.

  2022cites this paper
• Recent advances in on-site mass spectrometry analysis for clinical applications

  2022cites this paper
• FACS-assisted single-cell lipidome analysis of phosphatidylcholines and sphingomyelins in cells of different lineages

  2022cites this paper
• Advances in measuring cancer cell metabolism with subcellular resolution

  2022cites this paper
• The limitless applications of single-cell metabolomics.

  2021cites this paper
• Single-Cell Metabolomics by Mass Spectrometry: Opportunities and Challenges

  2021cites this paper
• Single-cell metabolite analysis on a microfluidic chip

  2021cites this paper
• Single-cell metabolomics reveals the metabolic heterogeneity among microbial cells

  2021cites this paper
• Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism

  2021cites this paper
• Proteomics for Low Cell Numbers: How to Optimize the Sample Preparation Workflow for Mass Spectrometry Analysis

  2021cites this paper
• The Metabolic Flux Probe (MFP)—Secreted Protein as a Non-Disruptive Information Carrier for 13C-Based Metabolic Flux Analysis

  2021cites this paper
• Mass spectrometry-based strategies for single-cell metabolomics.

  2021cites this paper
• Optical Microscopy-Guided Laser Ablation Electrospray Ionization Ion Mobility Mass Spectrometry: Ambient Single Cell Metabolomics with Increased Confidence in Molecular Identification

  2021cites this paper
• Single cell metabolomics using mass spectrometry: Techniques and data analysis.

  2021cites this paper
• Development of MALDI Mass Spectrometry Imaging Methods for Probing Spatial Lipid Biochemistry of Amyloid Plaques in Alzheimer's Disease

  2020cites this paper
• Estimating the Probability of Early Afterdepolarization and Predicting Arrhythmic Risk associated with Long QT Syndrome Type 1 Mutations

  2020cites this paper
• An analytical retrospection of mass spectrometric tools established for plant tissue culture: Current endeavours and future perspectives

  2020cites this paper
• Automation of mass spectrometric detection of analytes and related workflows: A review.

  2020cites this paper
• Single-cell Metabolomics Analysis by Microfluidics and Mass Spectrometry: Recent New Advances

  2020cites this paper
• Title: Estimating the Probability of Cellular Arrhythmias with Simplified Statistical Models that Account for Experimentally Observed Uncertainty

  2020cites this paper
• In situ analysis of single cell and biological samples with rGO-Cu functional probe ESI-MS spectrometry.

  2020cites this paper
• Capillary-assisted microfluidic biosensing platform captures single cell secretion dynamics in nanoliter compartments.

  2020cites this paper
• An Analytical System for Single-Cell Metabolomics of Typical Mammalian Cells Based on Highly Sensitive Nano-Liquid Chromatography Tandem Mass Spectrometry

  2020cites this paper
• Plasmonic Gold Templates Enhancing Single Cell Lipidomic Analysis of Microorganisms.

  2020cites this paper
• Single Cell Metabolomics: A Future Tool to Unmask Cellular Heterogeneity and Virus-Host Interaction in Context of Emerging Viral Diseases

  2020cites this paper
• Sample Preparation and Analysis of Single Cells Using High Performance MALDI FTICR Mass Spectrometry.

  2020cites this paper
• Introducing charge tag via click reaction in living cells for single cell mass spectrometry†

  2020cites this paper
• Single-cell metabolomics by mass spectrometry: Advances, challenges, and future applications

  2019cites this paper
• Transmission-mode MALDI-2 mass spectrometry imaging of cells and tissues at subcellular resolution

  2019cites this paper
• Native state single-cell printing system and analysis for matrix effects.

  2019cites this paper
• Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors.

  2019cites this paper
• Ultrasensitive Electrochemiluminescence Aptasensor for Assessment of Protein Heterogeneity in Small Cell Population.

  2019cites this paper
• Single-Cell Metabolomics: Technology and Applications

  2019cites this paper
• Recent advances in single-cell analysis by mass spectrometry.

  2019cites this paper
• Exploring the Fundamental Structures of Life: Non-Targeted, Chemical Analysis of Single Cells and Subcellular Structures.

  2019cites this paper
• High throughput screening of complex biological samples with mass spectrometry - from bulk measurements to single cell analysis.

  2019cites this paper
• Deciphering metabolic heterogeneity by single-cell analysis.

  2019cites this paper
• Cellular-Specific Detection of Polyphenolic Compounds by NMR-and MS-Based Techniques

  2019cites this paper
• Erforschung der fundamentalen Strukturen des Lebens: Nicht zielgerichtete chemische Analyse von Einzelzellen und subzellulären Strukturen

  2019cites this paper
• Quantitation of Glucose-phosphate in Single Cells by Microwell-Based Nanoliter Droplet Microextraction and Mass Spectrometry.

  2019cites this paper
• A concise tutorial review of TOF-SIMS based molecular and cellular imaging

  2019cites this paper
• A New Binary Matrix for Specific Detection of Mercury(II) Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry

  2019cites this paper
• Quantifying a Biocatalytic Product from a Few Living Microbial Cells Using Microfluidic Cultivation Coupled to FT-ICR-MS.

  2019cites this paper
• Cell analysis on chip-mass spectrometry

  2018cites this paper
• Microfluidics-Mass Spectrometry for Cell Analysis

  2018cites this paper
• Detection of Metabolites in Cells through Surface-Assisted Laser Desorption/Ionization Mass Spectrometry

  2018cites this paper
• A brief review on mass/optical spectrometry for imaging analysis of biological samples

  2018cites this paper
• Genome‐scale metabolic models applied to human health and disease

  2017cites this paper
• Recent Advances and Perspectives in Microfluidics‐Based Single‐Cell Biosensing Techniques

  2017cites this paper
• Single-cell analysis by ambient mass spectrometry

  2017cites this paper
• Single Cell Profiling Using Ionic Liquid Matrix-Enhanced Secondary Ion Mass Spectrometry for Neuronal Cell Type Differentiation.

  2017cites this paper
• Nanopost array laser desorption ionization mass spectrometry (NAPA-LDI MS): Gathering moss?

  2017cites this paper
• Printed droplet microfluidics for on demand dispensing of picoliter droplets and cells

  2017cites this paper
• Metabolic profiling and imaging of CHO cells for fusion protein production

  2017cites this paper
• Profiling and quantifying endogenous molecules in single cells using nano-DESI MS.

  2017cites this paper
• Through the Organism’s eyes : The interaction between hydrodynamics and metabolic dynamics in industrial-scale fermentation processes

  2017cites this paper
• Single-Cell Metabolomics

  2016cites this paper
• Single-Cell Metabolite Profiling of Stalk and Glandular Cells of Intact Trichomes with Internal Electrode Capillary Pressure Probe Electrospray Ionization Mass Spectrometry.

  2016cites this paper
• Applications of the Single-probe: Mass Spectrometry Imaging and Single Cell Analysis under Ambient Conditions

  2016cites this paper
• Lipidomic Analysis of Marine Microalgae

  2016cites this paper
• Single-Cell Mass Spectrometry for High-Throughput Lipid Phenotyping of Chlamydomonas reinhardtii

  2016cites this paper
• Pulsed Direct Current Electrospray: Enabling Systematic Analysis of Small Volume Sample by Boosting Sample Economy.

  2015cites this paper
• Screening of Chlamydomonas reinhardtii Populations with Single-Cell Resolution by Using a High-Throughput Microscale Sample Preparation for Matrix-Assisted Laser Desorption Ionization Mass Spectrometry

  2015cites this paper
• Mass spectrometry-based characterization of endogenous peptides and metabolites in small volume samples.

  2015cites this paper
• Direct metabolomics for plant cells by live single-cell mass spectrometry

  2015cites this paper
• Mass spectrometry imaging for the proteomic study of clinical tissue

  2015cites this paper
• Online analysis of single cyanobacteria and algae cells under nitrogen-limited conditions using aerosol time-of-flight mass spectrometry.

  2015cites this paper
• High resolution mass spectrometry imaging reveals the occurrence of phenylphenalenone-type compounds in red paracytic stomata and red epidermis tissue of Musa acuminata ssp. zebrina cv. 'Rowe Red'.

  2015cites this paper
• Surface-coated probe nanoelectrospray ionization mass spectrometry for analysis of target compounds in individual small organisms.

  2015cites this paper
• Nanoliter Segmented-Flow Sampling Mass Spectrometry with Online Compartmentalization

  2014cites this paper
• The Role of Mass Spectrometry in Nontargeted Metabolomics

  2014cites this paper
• Molecular phenotypic profiling of a Saccharomyces cerevisiae strain at the single-cell level.

  2014cites this paper
• Plant single-cell and single-cell-type metabolomics.

  2014cites this paper
• Single cell analysis with probe ESI-mass spectrometry: detection of metabolites at cellular and subcellular levels.

  2014cites this paper
• Evolution of microbial markets

  2014cites this paper